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Article Open Access

miR‑4732‑5p promotes ovarian cancer mobility by targeting MCUR1

  • Authors:
    • Xin Li
    • Xiaoqin Wang
    • Jun Wu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology No. 5, Ningbo Women and Children's Hospital, Ningbo, Zhejiang 315012, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 245
    |
    Published online on: April 20, 2023
       https://doi.org/10.3892/ol.2023.13831
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Abstract

MicroRNAs (miRNAs/miRs) play critical roles in tumor progression. However, the role of miR‑4732 and its underlying molecular mechanism in ovarian cancer (OC) remain unclear. In the present study, the high expression of miR‑4732 was confirmed to be associated with the mortality of patients with OC following surgery, according to The Cancer Genome Atlas Ovarian Cancer database (TCGA‑OV). Additionally, the expression of miR‑4732 was positively associated with an increased tendency to exhibit an early TNM stage (IIA, IIB and IIC) of OC, indicating its promotional role in the early stages of tumorigenesis. By performing in vitro gain‑of‑function experiments, the transient transfection of IGROV1 cells with miR‑4732‑5p mimics enhanced cell viability according to Cell Counting Kit‑8 assay, and cell migration and invasion in Transwell assays. However, though the application of loss‑of‑function experiments, the transient transfection of IGROV1 cells with miR‑4732‑5p inhibitors hindered cell viability, cell migration and invasion in vitro. Mitochondrial calcium uniporter regulator 1 (MCUR1) was validated as a downstream direct target of miR‑4732‑5p through bioinformatics analysis, western blotting and luciferase assays. Therefore, the results of the present study provide evidence that miR‑4732‑5p may promote OC cell mobility through the direct targeting of the tumor suppressor, MCUR1.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Wang X and Wu J: miR‑4732‑5p promotes ovarian cancer mobility by targeting MCUR1. Oncol Lett 25: 245, 2023.
APA
Li, X., Wang, X., & Wu, J. (2023). miR‑4732‑5p promotes ovarian cancer mobility by targeting MCUR1. Oncology Letters, 25, 245. https://doi.org/10.3892/ol.2023.13831
MLA
Li, X., Wang, X., Wu, J."miR‑4732‑5p promotes ovarian cancer mobility by targeting MCUR1". Oncology Letters 25.6 (2023): 245.
Chicago
Li, X., Wang, X., Wu, J."miR‑4732‑5p promotes ovarian cancer mobility by targeting MCUR1". Oncology Letters 25, no. 6 (2023): 245. https://doi.org/10.3892/ol.2023.13831
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Wang X and Wu J: miR‑4732‑5p promotes ovarian cancer mobility by targeting MCUR1. Oncol Lett 25: 245, 2023.
APA
Li, X., Wang, X., & Wu, J. (2023). miR‑4732‑5p promotes ovarian cancer mobility by targeting MCUR1. Oncology Letters, 25, 245. https://doi.org/10.3892/ol.2023.13831
MLA
Li, X., Wang, X., Wu, J."miR‑4732‑5p promotes ovarian cancer mobility by targeting MCUR1". Oncology Letters 25.6 (2023): 245.
Chicago
Li, X., Wang, X., Wu, J."miR‑4732‑5p promotes ovarian cancer mobility by targeting MCUR1". Oncology Letters 25, no. 6 (2023): 245. https://doi.org/10.3892/ol.2023.13831
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