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Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer

  • Authors:
    • Weimin Wang
    • Jun Jin
    • Zhen Zhou
    • Yunfan Wang
    • Ke Min
    • Xin Zuo
    • Jiaping Jiang
    • Yan Zhou
    • Jun Shi
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Yixing Hospital Affiliated to Medical College of Yangzhou University, Yixing, Jiangsu 214200, P.R. China, Department of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China, Department of General Surgery, Yixing Hospital Affiliated to Medical College of Yangzhou University, Yangzhou University, Yixing, Jiangsu 214200, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 271
    |
    Published online on: May 5, 2023
       https://doi.org/10.3892/ol.2023.13857
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Abstract

The overall survival (OS) rate of patients with colorectal cancer (CRC) remains low due to the lack of clear prognostic markers. Therefore, the identification of valuable prognostic markers is urgently required. Snail and E‑Cadherin (E‑Cad) are important protein molecules in the EMT process and play a crucial role in tumor invasion and metastasis. The present study investigated the clinical significance of Snail and E‑cad expression in CRC. Compared with those in adjacent tissue, the expression levels of Snail and E‑cad were significantly increased and decreased, respectively, in CRC. Moreover, low Snail and high E‑cad expression were associated with clinicopathological features and longer OS time. Furthermore, Snail and E‑cad could predict the prognosis of patients with CRC. Reverse transcription‑qPCR, Western blotting, Wound scratch assay, High content cell migration experiment, which showed that low Snail or high E‑cad expression inhibited invasion and metastasis of CRC. In conclusion, Snail can promote CRC invasion and metastasis by regulating E‑cad. Snail and E‑cad expression constitute a novel prognostic marker for CRC, and the present study revealed a greater combined effect of Snail and E‑cad as effective prognostic markers in CRC for the first time.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global patterns and trends in colorectal cancer incidence and mortality. Gut. 66:683–691. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 7:131–142. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, Schreiber M, Mikulits W, Brabletz T, Strand D, Obrist P, et al: The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene. 26:6979–6988. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Whiteman EL, Liu CJ, Fearon ER and Margolis B: The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes. Oncogene. 27:3875–3879. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Gumbiner B, Stevenson B and Grimaldi A: The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J Cell Biol. 107:1575–1587. 1988. View Article : Google Scholar : PubMed/NCBI

7 

Gumbiner BM: Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol. 6:622–634. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Navarro P, Gómez M, Pizarro A, Gamallo C, Quintanilla M and Cano A: A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. J Cell Biol. 115:517–533. 1991. View Article : Google Scholar : PubMed/NCBI

9 

Wang W, Li D, Xiang L, Lv M, Tao L, Ni T, Deng J, Gu X, Masatara S, Liu Y and Zhou Y: TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9. Cell Adh Migr. 13:273–284. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Wang W, Chen Y, Deng J, Zhou J, Gu X, Tang Y, Zhang G, Tan Y, Ge Z, Huang Y, et al: Cullin1 is a novel prognostic marker and regulates the cell proliferation and metastasis in colorectal cancer. J Cancer Res Clin Oncol. 141:1603–1612. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Wang S, Wu X, Chen Y, Zhang J, Ding J, Zhou Y, He S, Tan Y, Qiang F, Bai J, et al: Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer. Clin Cancer Res. 18:2987–2996. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Wang T, Gao X, Chen S, Li D, Chen S, Xie M, Xu Z and Yang G: Genome-wide identification and expression analysis of ethylene responsive factor family transcription factors in Juglans regia. PeerJ. 9:e124292021. View Article : Google Scholar : PubMed/NCBI

13 

Austin H, Henley SJ, King J, Richardson LC and Eheman C: Changes in colorectal cancer incidence rates in young and older adults in the United States: What does it tell us about screening. Cancer Causes Control. 25:191–201. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Bhandari A, Woodhouse M and Gupta S: Colorectal cancer is a leading cause of cancer incidence and mortality among adults younger than 50 years in the USA: A SEER-based analysis with comparison to other young-onset cancers. J Investig Med. 65:311–315. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, et al: SEER cancer statistics review, 1975–2012. National Cancer Institute; Bethesda, MD: 2014

16 

Singh KE, Taylor TH, Pan CG, Stamos MJ and Zell JA: Colorectal cancer incidence among young adults in California. J Adolesc Young Adult Oncol. 3:176–184. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Young JP, Win AK, Rosty C, Flight I, Roder D, Young GP, Frank O, Suthers GK, Hewett PJ, Ruszkiewicz A, et al: Rising incidence of early-onset colorectal cancer in Australia over two decades: Report and review. J Gastroenterol Hepatol. 30:6–13. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Wang L, Cho KB, Li Y, Tao G, Xie Z and Guo B: Long noncoding RNA (lncRNA)-mediated competing endogenous RNA networks provide novel potential biomarkers and therapeutic targets for colorectal cancer. Int J Mol Sci. 20:57582019. View Article : Google Scholar : PubMed/NCBI

19 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Hay ED: An overview of epithelio-mesenchymal transformation. Acta Anat (Basel). 154:8–20. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Kalluri R and Weinberg RA: The basics of epithelial- mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Nieto MA: The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol. 3:155–166. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Chen WJ, Wang H, Tang Y, Liu CL, Li HL and Li WT: Multidrug resistance in breast cancer cells during epithelial-mesenchymal transition is modulated by breast cancer resistant protein. Chin J Cancer. 29:151–157. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero CP, Sterner CJ, Notorfrancesco KL, Cardiff RD and Chodosh LA: The transcriptional repressor snail promotes mammary tumor recurrence. Cancer Cell. 8:197–209. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Ye Y, Xiao Y, Wang W, Yearsley K, Gao JX and Barsky SH: ERalpha suppresses slug expression directly by transcriptional repression. Biochem J. 416:179–187. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Ye Y, Xiao Y, Wang W, Yearsley K, Gao JX, Shetuni B and Barsky SH: ERalpha signaling through slug regulates E-cadherin and EMT. Oncogene. 29:1451–1462. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Kurrey NK, Jalgaonkar SP, Joglekar AV, Ghanate AD, Chaskar PD, Doiphode RY and Bapat SA: Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells. 27:2059–2068. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang W, Jin J, Zhou Z, Wang Y, Min K, Zuo X, Jiang J, Zhou Y and Shi J: Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer. Oncol Lett 25: 271, 2023.
APA
Wang, W., Jin, J., Zhou, Z., Wang, Y., Min, K., Zuo, X. ... Shi, J. (2023). Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer. Oncology Letters, 25, 271. https://doi.org/10.3892/ol.2023.13857
MLA
Wang, W., Jin, J., Zhou, Z., Wang, Y., Min, K., Zuo, X., Jiang, J., Zhou, Y., Shi, J."Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer". Oncology Letters 25.6 (2023): 271.
Chicago
Wang, W., Jin, J., Zhou, Z., Wang, Y., Min, K., Zuo, X., Jiang, J., Zhou, Y., Shi, J."Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer". Oncology Letters 25, no. 6 (2023): 271. https://doi.org/10.3892/ol.2023.13857
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Jin J, Zhou Z, Wang Y, Min K, Zuo X, Jiang J, Zhou Y and Shi J: Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer. Oncol Lett 25: 271, 2023.
APA
Wang, W., Jin, J., Zhou, Z., Wang, Y., Min, K., Zuo, X. ... Shi, J. (2023). Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer. Oncology Letters, 25, 271. https://doi.org/10.3892/ol.2023.13857
MLA
Wang, W., Jin, J., Zhou, Z., Wang, Y., Min, K., Zuo, X., Jiang, J., Zhou, Y., Shi, J."Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer". Oncology Letters 25.6 (2023): 271.
Chicago
Wang, W., Jin, J., Zhou, Z., Wang, Y., Min, K., Zuo, X., Jiang, J., Zhou, Y., Shi, J."Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer". Oncology Letters 25, no. 6 (2023): 271. https://doi.org/10.3892/ol.2023.13857
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