Open Access

Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer

  • Authors:
    • Weimin Wang
    • Jun Jin
    • Zhen Zhou
    • Yunfan Wang
    • Ke Min
    • Xin Zuo
    • Jiaping Jiang
    • Yan Zhou
    • Jun Shi
  • View Affiliations

  • Published online on: May 5, 2023     https://doi.org/10.3892/ol.2023.13857
  • Article Number: 271
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The overall survival (OS) rate of patients with colorectal cancer (CRC) remains low due to the lack of clear prognostic markers. Therefore, the identification of valuable prognostic markers is urgently required. Snail and E‑Cadherin (E‑Cad) are important protein molecules in the EMT process and play a crucial role in tumor invasion and metastasis. The present study investigated the clinical significance of Snail and E‑cad expression in CRC. Compared with those in adjacent tissue, the expression levels of Snail and E‑cad were significantly increased and decreased, respectively, in CRC. Moreover, low Snail and high E‑cad expression were associated with clinicopathological features and longer OS time. Furthermore, Snail and E‑cad could predict the prognosis of patients with CRC. Reverse transcription‑qPCR, Western blotting, Wound scratch assay, High content cell migration experiment, which showed that low Snail or high E‑cad expression inhibited invasion and metastasis of CRC. In conclusion, Snail can promote CRC invasion and metastasis by regulating E‑cad. Snail and E‑cad expression constitute a novel prognostic marker for CRC, and the present study revealed a greater combined effect of Snail and E‑cad as effective prognostic markers in CRC for the first time.
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June-2023
Volume 25 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang W, Jin J, Zhou Z, Wang Y, Min K, Zuo X, Jiang J, Zhou Y and Shi J: Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer. Oncol Lett 25: 271, 2023
APA
Wang, W., Jin, J., Zhou, Z., Wang, Y., Min, K., Zuo, X. ... Shi, J. (2023). Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer. Oncology Letters, 25, 271. https://doi.org/10.3892/ol.2023.13857
MLA
Wang, W., Jin, J., Zhou, Z., Wang, Y., Min, K., Zuo, X., Jiang, J., Zhou, Y., Shi, J."Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer". Oncology Letters 25.6 (2023): 271.
Chicago
Wang, W., Jin, J., Zhou, Z., Wang, Y., Min, K., Zuo, X., Jiang, J., Zhou, Y., Shi, J."Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer". Oncology Letters 25, no. 6 (2023): 271. https://doi.org/10.3892/ol.2023.13857