Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2023 Volume 26 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2023 Volume 26 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta‑analysis

  • Authors:
    • Jiye Liu
    • Hanyong Luo
    • Letian Huang
    • Jiahe Wang
  • View Affiliations / Copyright

    Affiliations: Department of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110000, P.R. China, Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 283
    |
    Published online on: May 18, 2023
       https://doi.org/10.3892/ol.2023.13869
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sarcopenia is a common condition in patients with hepatocellular carcinoma (HCC). Sarcopenia affects the prognosis of patients with HCC and reduces their quality of life. However, to date, there has been no systematic review and meta‑analysis to assess the prevalence of sarcopenia in patients with HCC, to the best of our knowledge. PubMed, Embase, Web of Science and the Cochrane Library were comprehensively screened for relevant literature published from March 2001 to June 2022. A random effect analysis was conducted to pool the incidence rates for each study. Subgroup and meta‑regression analyses were used to investigate the latent sources of heterogeneities. The Newcastle‑Ottawa Scale was used to estimate the quality of the included studies. The I2 statistic was used to evaluate heterogeneity between studies. In total, 48 studies encompassing 8,959 patients were included in the meta‑analysis. The results of the present meta‑analysis showed that nearly half (42%) of the patients with HCC had sarcopenia (95% CI, 0.36‑0.48). The morbidity of sarcopenia in studies with a high proportion of males (45%) was higher compared with the morbidity observed in studies with a lower proportion of males (37%). In addition, the incidence rate in younger patients (46%) was found to be higher compared with the incidence rate in older patients (39%). In conclusion, the findings in the present systematic review revealed that a large number of patients with HCC suffer from sarcopenia, indicating the necessity of developing screening and intervention measures to improve the outcome in these patients.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Hartke J, Johnson M and Ghabril M: The diagnosis and treatment of hepatocellular carcinoma. Semin Diagn Pathol. 34:153–159. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Rumgay H, Arnold M, Ferlay J, Lesi O, Cabasag CJ, Vignat J, Laversanne M, McGlynn KA and Soerjomataram I: Global burden of primary liver cancer in 2020 and predictions to 2040. J Hepatol. 77:1598–1606. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Li C and He WQ: Comparison of primary liver cancer mortality estimates from World Health Organization, global burden disease and global cancer observatory. Liver Int. 42:2299–2316. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Clark T, Maximin S, Meier J, Pokharel S and Bhargava P: Hepatocellular carcinoma: Review of epidemiology, screening, imaging diagnosis, response assessment, and treatment. Curr Probl Diagn Radiol. 44:479–486. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Villanueva A: Hepatocellular carcinoma. N Engl J Med. 380:1450–1462. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Chang KV, Chen JD, Wu WT, Huang KC, Hsu CT and Han DS: Association between loss of skeletal muscle mass and mortality and tumor recurrence in hepatocellular carcinoma: A systematic review and meta-analysis. Liver Cancer. 7:90–103. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Papadopoulou SK: Sarcopenia: A contemporary health problem among older adult populations. Nutrients. 12:12932020. View Article : Google Scholar : PubMed/NCBI

8 

Rier HN, Jager A, Sleijfer S, Maier AB and Levin MD: The prevalence and prognostic value of low muscle mass in cancer patients: A review of the literature. Oncologist. 21:1396–1409. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Gibson DJ, Burden ST, Strauss BJ, Todd C and Lal S: The role of computed tomography in evaluating body composition and the influence of reduced muscle mass on clinical outcome in abdominal malignancy: A systematic review. Eur J Clin Nutr. 69:1079–1086. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Shachar SS, Williams GR, Muss HB and Nishijima TF: Prognostic value of sarcopenia in adults with solid tumours: A meta-analysis and systematic review. Eur J Cancer. 57:58–67. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P and Stewart LA; PRISMA-P Group, : Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 4:12015. View Article : Google Scholar : PubMed/NCBI

12 

Lo CK, Mertz D and Loeb M: Newcastle-Ottawa Scale: Comparing reviewers' to authors' assessments. BMC Med Res Methodol. 14:452014. View Article : Google Scholar : PubMed/NCBI

13 

Borenstein M, Hedges LV, Higgins JP and Rothstein HR: A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 1:97–111. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Duval S and Tweedie R: Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 56:455–463. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Alsebaey A, Sabry A, Rashed HS, Elsabaawy MM, Ragab A, Aly RA and Badran H: MELD-sarcopenia is better than ALBI and MELD score in patients with hepatocellular carcinoma awaiting liver transplantation. Asian Pac J Cancer Prev. 22:2005–2009. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Akce M, Liu Y, Zakka KM, Martini DJ, Draper A, Alese OB, Shaib WL, Wu C, Wedd J, Sellers MT, et al: The impact of inflammatory biomarkers, BMI, and sarcopenia on survival in advanced hepatocellular carcinoma treated with immunotherapy. J Clin Oncol. 38 (4 Suppl):S5532020. View Article : Google Scholar

18 

Begini P, Gigante E, Antonelli G, Carbonetti F, Iannicelli E, Anania G, Imperatrice B, Pellicelli AM, Fave GD and Marignani M: Sarcopenia predicts reduced survival in patients with hepatocellular carcinoma at first diagnosis. Ann Hepatol. 16:107–114. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Dong D, Shi JY, Shang X, Liu B, Xu WL, Cui GZ and Wang NY: Prognostic significance of sarcopenia in patients with hepatocellular carcinoma treated with lenvatinib: A retrospective analysis. Medicine (Baltimore). 101:e286802022. View Article : Google Scholar : PubMed/NCBI

20 

Guichet PL, Taslakian B, Zhan C, Aaltonen E, Farquharson S, Hickey R, Horn CJ and Gross JS: MRI-derived sarcopenia associated with increased mortality following yttrium-90 radioembolization of hepatocellular carcinoma. Cardiovasc Intervent Radiol. 44:1561–1569. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Ha Y, Kim D, Han S, Chon YE, Lee YB, Kim MN, Lee JH, Park H, Rim KS and Hwang SG: Sarcopenia predicts prognosis in patients with newly diagnosed hepatocellular carcinoma, independent of tumor stage and liver function. Cancer Res Treat. 50:843–851. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Hirota K, Kawaguchi T, Koya S, Nagamatsu A, Tomita M, Hashida R, Nakano D, Niizeki T, Matsuse H, Shiba N and Torimura T: Clinical utility of the liver frailty index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma. Hepatol Res. 50:330–341. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Imai K, Takai K, Watanabe S, Hanai T, Suetsugu A, Shiraki M and Shimizu M: Sarcopenia impairs prognosis of patients with hepatocellular carcinoma: The role of liver functional reserve and tumor-related factors in loss of skeletal muscle volume. Nutrients. 9:10542017. View Article : Google Scholar : PubMed/NCBI

24 

Kim YR, Park S, Han S, Ahn JH, Kim S, Sinn DH, Jeong WK, Ko JS, Gwak MS and Kim GS: Sarcopenia as a predictor of post-transplant tumor recurrence after living donor liver transplantation for hepatocellular carcinoma beyond the Milan criteria. Sci Rep. 8:71572018. View Article : Google Scholar : PubMed/NCBI

25 

Kobayashi A, Kaido T, Hamaguchi Y, Okumura S, Shirai H, Yao S, Kamo N, Yagi S, Taura K, Okajima H and Uemoto S: Impact of sarcopenic obesity on outcomes in patients undergoing hepatectomy for hepatocellular carcinoma. Ann Surg. 269:924–931. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Kobayashi T, Kawai H, Nakano O, Abe S, Kamimura H, Sakamaki A, Kamimura K, Tsuchiya A, Takamura M, Yamagiwa S and Terai S: Rapidly declining skeletal muscle mass predicts poor prognosis of hepatocellular carcinoma treated with transcatheter intra-arterial therapies. BMC Cancer. 18:7562018. View Article : Google Scholar : PubMed/NCBI

27 

Kotoh Y, Saeki I, Yamasaki T, Sasaki R, Tanabe N, Oono T, Matsuda T, Hisanaga T, Matsumoto T, Hidaka I, et al: Effect of handgrip strength on clinical outcomes of patients with hepatocellular carcinoma treated with lenvatinib. Appl Sci. 10:54032020. View Article : Google Scholar

28 

Kroh A, Uschner D, Lodewick T, Eickhoff RM, Schöning W, Ulmer FT, Neumann UP and Binnebösel M: Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients. Hepatobiliary Pancreat Dis Int. 18:28–37. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Lanza E, Masetti C, Messana G, Muglia R, Pugliese N, Ceriani R, Lleo de Nalda A, Rimassa L, Torzilli G, Poretti D, et al: Sarcopenia as a predictor of survival in patients undergoing bland transarterial embolization for unresectable hepatocellular carcinoma. PLoS One. 15:e02323712020. View Article : Google Scholar : PubMed/NCBI

30 

Lee J, Cho Y, Park S, Kim JW and Lee IJ: Skeletal muscle depletion predicts the prognosis of patients with hepatocellular carcinoma treated with radiotherapy. Front Oncol. 9:10752019. View Article : Google Scholar : PubMed/NCBI

31 

Levolger S, van Vledder MG, Muslem R, Koek M, Niessen WJ, de Man RA, de Bruin RW and Ijzermans JN: Sarcopenia impairs survival in patients with potentially curable hepatocellular carcinoma. J Surg Oncol. 112:208–213. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Liao C, Li G, Bai Y, Zhou S, Huang L, Yan M, Qiu F, Chen J, Wang Y, Tian Y and Chen S: Prognostic value and association of sarcopenic obesity and systemic inflammatory indexes in patients with hepatocellular carcinoma following hepatectomy and the establishment of novel predictive nomograms. J Gastrointest Oncol. 12:669–693. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Meister FA, Lurje G, Verhoeven S, Wiltberger G, Heij L, Liu WJ, Jiang D, Bruners P, Lang SA, Ulmer TF, et al: The role of sarcopenia and myosteatosis in short- and long-term outcomes following curative-intent surgery for hepatocellular carcinoma in a European cohort. Cancers (Basel). 14:7202022. View Article : Google Scholar : PubMed/NCBI

34 

Meza-Junco J, Montano-Loza AJ, Baracos VE, Prado CM, Bain VG, Beaumont C, Esfandiari N, Lieffers JR and Sawyer MB: Sarcopenia as a prognostic index of nutritional status in concurrent cirrhosis and hepatocellular carcinoma. J Clin Gastroenterol. 47:861–870. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Salman A, Salman M, Moustafa A, Shaaban HE, El-Mikkawy A, Labib S, Youssef A, Omar MG, Matter M and Elkassar H: Impact of sarcopenia on two-year mortality in patients with hcv-associated hepatocellular carcinoma after radiofrequency ablation. J Hepatocell Carcinoma. 8:313–320. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Salman MA, Omar HSE, Mikhail HMS, Tourky M, El-Ghobary M, Elkassar H, Omar MG, Matter M, Elbasiouny AM, Farag AM, et al: Sarcopenia increases 1-year mortality after surgical resection of hepatocellular carcinoma. ANZ J Surg. 90:781–785. 2020. View Article : Google Scholar : PubMed/NCBI

37 

Shiba S, Shibuya K, Katoh H, Koyama Y, Okamoto M, Abe T, Ohno T and Nakano T: No deterioration in clinical outcomes of carbon ion radiotherapy for sarcopenia patients with hepatocellular carcinoma. Anticancer Res. 38:3579–3586. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Takagi K, Yagi T, Yoshida R, Shinoura S, Umeda Y, Nobuoka D, Kuise T, Watanabe N and Fujiwara T: Sarcopenia and American society of anesthesiologists physical status in the assessment of outcomes of hepatocellular carcinoma patients undergoing hepatectomy. Acta Med Okayama. 70:363–370. 2016.PubMed/NCBI

39 

Antonelli G, Gigante E, Iavarone M, Begini P, Sangiovanni A, Iannicelli E, Biondetti P, Pellicelli AM, Miglioresi L, Marchetti P, et al: Sarcopenia is associated with reduced survival in patients with advanced hepatocellular carcinoma undergoing sorafenib treatment. United European Gastroenterol J. 6:1039–1048. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Harimoto N, Shirabe K, Yamashita YI, Ikegami T, Yoshizumi T, Soejima Y, Ikeda T, Maehara Y, Nishie A and Yamanaka T: Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma. Br J Surg. 100:1523–1530. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Nishikawa H, Nishijima N, Enomoto H, Sakamoto A, Nasu A, Komekado H, Nishimura T, Kita R, Kimura T, Iijima H, et al: Prognostic significance of sarcopenia in patients with hepatocellular carcinoma undergoing sorafenib therapy. Oncol Lett. 14:1637–1647. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Chen BB, Liang PC, Shih TT, Liu TH, Shen YC, Lu LC, Lin ZZ, Hsu C, Hsu CH, Cheng AL and Shao YY: Sarcopenia and myosteatosis are associated with survival in patients receiving immunotherapy for advanced hepatocellular carcinoma. Eur Radiol. 33:512–522. 2023. View Article : Google Scholar : PubMed/NCBI

43 

Naganuma A, Hoshino T, Suzuki Y, Uehara D, Kudo T, Ishihara H, Sato K, Kakizaki S, Yamada M and Takagi H: Association between skeletal muscle depletion and sorafenib treatment in male patients with hepatocellular carcinoma: A retrospective cohort study. Acta Med Okayama. 71:291–299. 2017.PubMed/NCBI

44 

Mardian Y, Yano Y, Ratnasari N, Choridah L, Wasityastuti W, Setyawan NH and Hayashi Y: ‘Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: A retrospective study’. BMC Gastroenterol. 19:2292019. View Article : Google Scholar : PubMed/NCBI

45 

Badran H, Elsabaawy MM, Ragab A, Aly RA, Alsebaey A and Sabry A: Baseline sarcopenia is associated with lack of response to therapy, liver decompensation and high mortality in hepatocellular carcinoma patients. Asian Pac J Cancer Prev. 21:3285–3290. 2020. View Article : Google Scholar : PubMed/NCBI

46 

Hou GM, Jiang C, Du JP and Yuan KF: Sarcopenia predicts an adverse prognosis in patients with combined hepatocellular carcinoma and cholangiocarcinoma after surgery. Cancer Med. 11:317–331. 2022. View Article : Google Scholar : PubMed/NCBI

47 

Imai K, Takai K, Miwa T, Taguchi D, Hanai T, Suetsugu A, Shiraki M and Shimizu M: Rapid depletion of subcutaneous adipose tissue during sorafenib treatment predicts poor survival in patients with hepatocellular carcinoma. Cancers (Basel). 12:17952020. View Article : Google Scholar : PubMed/NCBI

48 

Endo K, Kuroda H, Kanazawa J, Sato T, Fujiwara Y, Abe T, Sato H, Kooka Y, Oikawa T, Sawara K and Takikawa Y: Impact of grip strength in patients with unresectable hepatocellular carcinoma treated with lenvatinib. Cancers (Basel). 12:21462020. View Article : Google Scholar : PubMed/NCBI

49 

Choi K, Jang HY, Ahn JM, Hwang SH, Chung JW, Choi YS, Kim JW, Jang ES, Choi GH and Jeong SH: The association of the serum levels of myostatin, follistatin, and interleukin-6 with sarcopenia, and their impacts on survival in patients with hepatocellular carcinoma. Clin Mol Hepatol. 26:492–505. 2020. View Article : Google Scholar : PubMed/NCBI

50 

Harimoto N, Yoshizumi T, Shimokawa M, Sakata K, Kimura K, Itoh S, Ikegami T, Ikeda T, Shirabe K and Maehara Y: Sarcopenia is a poor prognostic factor following hepatic resection in patients aged 70 years and older with hepatocellular carcinoma. Hepatol Res. 46:1247–1255. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Kamachi S, Mizuta T, Otsuka T, Nakashita S, Ide Y, Miyoshi A, Kitahara K, Eguchi Y, Ozaki I and Anzai K: Sarcopenia is a risk factor for the recurrence of hepatocellular carcinoma after curative treatment. Hepatol Res. 46:201–208. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Zhang JX, Yan HT, Ding Y, Liu J, Liu S, Zu QQ and Shi HB: Low psoas-muscle index is associated with decreased survival in hepatocellular carcinoma treated with transarterial chemoembolization. Ann Med. 54:1562–1569. 2022. View Article : Google Scholar : PubMed/NCBI

53 

Yabusaki N, Fujii T, Yamada S, Suzuki K, Sugimoto H, Kanda M, Nakayama G, Koike M, Fujiwara M and Kodera Y: Adverse impact of low skeletal muscle index on the prognosis of hepatocellular carcinoma after hepatic resection. Int J Surg. 30:136–142. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Fujiwara N, Nakagawa H, Kudo Y, Tateishi R, Taguri M, Watadani T, Nakagomi R, Kondo M, Nakatsuka T, Minami T, et al: Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma. J Hepatol. 63:131–140. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Acosta LF, Galuppo R, García CR, Villacorta E, Dugan A, Castellanos AL, Gedaly R and Lee JT: Association between sarcopenia and AFP level in patients undergoing liver transplantation for hepatocellular carcinoma. J Surg Res. 238:10–15. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Yang J, Chen K, Zheng C, Chen K, Lin J, Meng Q, Chen Z, Deng L, Yu H, Deng T, et al: Impact of sarcopenia on outcomes of patients undergoing liver resection for hepatocellular carcinoma. J Cachexia Sarcopenia Muscle. 13:2383–2392. 2022. View Article : Google Scholar : PubMed/NCBI

57 

Hamaguchi Y, Kaido T, Okumura S, Kobayashi A, Shirai H, Yao S, Yagi S, Kamo N, Seo S, Taura K, et al: Preoperative visceral adiposity and muscularity predict poor outcomes after hepatectomy for hepatocellular carcinoma. Liver Cancer. 8:92–109. 2019. View Article : Google Scholar : PubMed/NCBI

58 

Uojima H, Chuma M, Tanaka Y, Hidaka H, Nakazawa T, Iwabuchi S, Kobayashi S, Hattori N, Ogushi K, Morimoto M, et al: Skeletal muscle mass influences tolerability and prognosis in hepatocellular carcinoma patients treated with lenvatinib. Liver Cancer. 9:193–206. 2020. View Article : Google Scholar : PubMed/NCBI

59 

Takada H, Kurosaki M, Nakanishi H, Takahashi Y, Itakura J, Tsuchiya K, Yasui Y, Tamaki N, Takaura K, Komiyama Y, et al: Impact of pre-sarcopenia in sorafenib treatment for advanced hepatocellular carcinoma. PLoS One. 13:e01988122018. View Article : Google Scholar : PubMed/NCBI

60 

Tan Y, Duan T, Li B, Zhang B, Zhu Y, Yan K, Song J, Lv T, Yang J, Jiang L, et al: Sarcopenia defined by psoas muscle index independently predicts long-term survival after living donor liver transplantation in male recipients. Quant Imaging Med Surg. 12:215–228. 2022. View Article : Google Scholar : PubMed/NCBI

61 

Kim N, Yu JI, Park HC, Yoo GS, Choi C, Hong JY, Lim HY, Lee J, Choi MS, Lee JE and Kim K: Incorporating sarcopenia and inflammation with radiation therapy in patients with hepatocellular carcinoma treated with nivolumab. Cancer Immunol Immunother. 70:1593–1603. 2021. View Article : Google Scholar : PubMed/NCBI

62 

Iritani S, Imai K, Takai K, Hanai T, Ideta T, Miyazaki T, Suetsugu A, Shiraki M, Shimizu M and Moriwaki H: Skeletal muscle depletion is an independent prognostic factor for hepatocellular carcinoma. J Gastroenterol. 50:323–232. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Voron T, Tselikas L, Pietrasz D, Pigneur F, Laurent A, Compagnon P, Salloum C, Luciani A and Azoulay D: Sarcopenia impacts on short- and long-term results of hepatectomy for hepatocellular carcinoma. Ann Surg. 261:1173–1183. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Bischoff-Ferrari HA, Orav JE, Kanis JA, Rizzoli R, Schlögl M, Staehelin HB, Willett WC and Dawson-Hughes B: Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older. Osteoporos Int. 26:2793–2802. 2015. View Article : Google Scholar : PubMed/NCBI

65 

Williams GR, Dunne RF, Giri S, Shachar SS and Caan BJ: Sarcopenia in the older adult with cancer. J Clin Oncol. 39:2068–2078. 2021. View Article : Google Scholar : PubMed/NCBI

66 

Giallauria F, Cittadini A, Smart NA and Vigorito C: Resistance training and sarcopenia. Monaldi Arch Chest Dis. 84:7382016. View Article : Google Scholar : PubMed/NCBI

67 

Fan J, Kou X, Yang Y and Chen N: MicroRNA-regulated proinflammatory cytokines in sarcopenia. Mediators Inflamm. 2016:14386862016. View Article : Google Scholar : PubMed/NCBI

68 

Sinclair M, Grossmann M, Angus PW, Hoermann R, Hey P, Scodellaro T and Gow PJ: Low testosterone as a better predictor of mortality than sarcopenia in men with advanced liver disease. J Gastroenterol Hepatol. 31:661–667. 2016. View Article : Google Scholar : PubMed/NCBI

69 

Phillips T and Leeuwenburgh C: Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB J. 19:668–670. 2005. View Article : Google Scholar : PubMed/NCBI

70 

Anderson LJ, Liu H and Garcia JM: Sex differences in muscle wasting. Adv Exp Med Biol. 1043:153–197. 2017. View Article : Google Scholar : PubMed/NCBI

71 

Janssen I, Heymsfield SB, Wang ZM and Ross R: Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr. J Appl Physiol (1985). 89:81–88. 2000. View Article : Google Scholar : PubMed/NCBI

72 

Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, Lencioni R, Koike K, Zucman-Rossi J and Finn RS: Hepatocellular carcinoma. Nat Rev Dis Primers. 7:62021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu J, Luo H, Huang L and Wang J: Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta‑analysis. Oncol Lett 26: 283, 2023.
APA
Liu, J., Luo, H., Huang, L., & Wang, J. (2023). Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta‑analysis. Oncology Letters, 26, 283. https://doi.org/10.3892/ol.2023.13869
MLA
Liu, J., Luo, H., Huang, L., Wang, J."Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta‑analysis". Oncology Letters 26.1 (2023): 283.
Chicago
Liu, J., Luo, H., Huang, L., Wang, J."Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta‑analysis". Oncology Letters 26, no. 1 (2023): 283. https://doi.org/10.3892/ol.2023.13869
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Luo H, Huang L and Wang J: Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta‑analysis. Oncol Lett 26: 283, 2023.
APA
Liu, J., Luo, H., Huang, L., & Wang, J. (2023). Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta‑analysis. Oncology Letters, 26, 283. https://doi.org/10.3892/ol.2023.13869
MLA
Liu, J., Luo, H., Huang, L., Wang, J."Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta‑analysis". Oncology Letters 26.1 (2023): 283.
Chicago
Liu, J., Luo, H., Huang, L., Wang, J."Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta‑analysis". Oncology Letters 26, no. 1 (2023): 283. https://doi.org/10.3892/ol.2023.13869
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team