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Neoadjuvant immune checkpoint inhibitor treatment + chemotherapy (vs. chemotherapy alone) for locally advanced non‑small cell lung cancer: A retrospective cohort study

  • Authors:
    • Yi Yang
    • Zaoyang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Third People's Hospital of Chengdu, Chengdu, Sichuan 610082, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 292
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    Published online on: May 22, 2023
       https://doi.org/10.3892/ol.2023.13878
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Abstract

Neoadjuvant immune checkpoint inhibitor (ICI) treatment + chemotherapy has been used for locally advanced non‑small cell lung cancer (NSCLC); however, evidence regarding the efficacy of this treatment is insufficient, particularly in Chinese patients. Therefore, the aim of the present study was to evaluate the efficacy and safety of neoadjuvant ICI treatment + chemotherapy compared with neoadjuvant chemotherapy alone for locally advanced NSCLC. For this, 50 patients with locally advanced NSCLC were retrospectively analyzed; of these, 23 patients received pre‑operative camrelizumab or sintilimab + chemotherapy (ICI + chemo group) and 27 patients received pre‑operative chemotherapy alone (chemo group). The objective response rate (73.9 vs. 44.4%, P=0.035) was superior in the ICI + chemo group compared with the chemo group. Nevertheless, surgical resection rate (100.0 vs. 88.9%, P=0.240), major pathological response (60.9 vs. 41.7%, P=0.188) and complete pathological response (CPR; 30.4 vs. 8.3%, P=0.072) were not significantly different in the ICI + chemo group compared with the chemo group. Following adjustment, ICI + chemo was independently associated with an elevated CPR (P=0.029). Disease‑free survival (DFS) was prolonged in the ICI + chemo group compared with the chemo group (1‑year DFS, 94.1 vs. 81.6%; 2‑year DFS, 80.7 vs. 42.9%; P=0.047), while no significant differences were observed in overall survival (OS; 1‑year OS, 100.0 vs. 95.7%; 2‑year OS, 90.0 vs. 64.9%; P=0.187). Additionally, the majority of adverse event incidences (apart from leukopenia) did not differ significantly between the ICI + chemo and chemo groups (all P>0.050). On the whole, the present study demonstrated that neoadjuvant ICI treatment + chemotherapy exhibited adequate efficacy and acceptable toxicity compared with chemotherapy alone in patients with locally advanced NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y and Liu Z: Neoadjuvant immune checkpoint inhibitor treatment + chemotherapy (vs. chemotherapy alone) for locally advanced non‑small cell lung cancer: A retrospective cohort study. Oncol Lett 26: 292, 2023.
APA
Yang, Y., & Liu, Z. (2023). Neoadjuvant immune checkpoint inhibitor treatment + chemotherapy (vs. chemotherapy alone) for locally advanced non‑small cell lung cancer: A retrospective cohort study. Oncology Letters, 26, 292. https://doi.org/10.3892/ol.2023.13878
MLA
Yang, Y., Liu, Z."Neoadjuvant immune checkpoint inhibitor treatment + chemotherapy (vs. chemotherapy alone) for locally advanced non‑small cell lung cancer: A retrospective cohort study". Oncology Letters 26.1 (2023): 292.
Chicago
Yang, Y., Liu, Z."Neoadjuvant immune checkpoint inhibitor treatment + chemotherapy (vs. chemotherapy alone) for locally advanced non‑small cell lung cancer: A retrospective cohort study". Oncology Letters 26, no. 1 (2023): 292. https://doi.org/10.3892/ol.2023.13878
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y and Liu Z: Neoadjuvant immune checkpoint inhibitor treatment + chemotherapy (vs. chemotherapy alone) for locally advanced non‑small cell lung cancer: A retrospective cohort study. Oncol Lett 26: 292, 2023.
APA
Yang, Y., & Liu, Z. (2023). Neoadjuvant immune checkpoint inhibitor treatment + chemotherapy (vs. chemotherapy alone) for locally advanced non‑small cell lung cancer: A retrospective cohort study. Oncology Letters, 26, 292. https://doi.org/10.3892/ol.2023.13878
MLA
Yang, Y., Liu, Z."Neoadjuvant immune checkpoint inhibitor treatment + chemotherapy (vs. chemotherapy alone) for locally advanced non‑small cell lung cancer: A retrospective cohort study". Oncology Letters 26.1 (2023): 292.
Chicago
Yang, Y., Liu, Z."Neoadjuvant immune checkpoint inhibitor treatment + chemotherapy (vs. chemotherapy alone) for locally advanced non‑small cell lung cancer: A retrospective cohort study". Oncology Letters 26, no. 1 (2023): 292. https://doi.org/10.3892/ol.2023.13878
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