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​Efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel for the treatment of HER2‑positive advanced breast cancer: A real‑world study

  • Authors:
    • Lixian Yang
    • Lei Zheng
    • Fanting Kong
    • Xinli Tian
    • Shiyu Zhang
    • Pengpeng Pu
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    Affiliations: Department of Breast Surgery, Xingtai People's Hospital, Xingtai, Hebei 054000, P.R. China, Medical Research Center, Xingtai Medical College, Xingtai, Hebei 054000, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 312
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    Published online on: June 6, 2023
       https://doi.org/10.3892/ol.2023.13898
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Abstract

he present study aimed to determine the efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel in patients with HER2‑positive advanced breast cancer (ABC). A total of 48 patients diagnosed with HER2‑positive ABC were included in the present study, and these patients were prescribed a combination of pyrotinib and albumin‑bound paclitaxel in routine clinical practice. During a 21‑day cycle, the standard dosage of pyrotinib was 400 mg single dose/day, which was administered orally, and 130 mg/m2/day albumin‑bound paclitaxel on days 1, 8 and 15, which was administered by intravenous drip. The primary efficacy endpoint was progression‑free survival (PFS) and the secondary efficacy endpoint was overall response rate (ORR), which was defined as the percentage of patients with complete remission or partial remission. Safety indicators were also observed in the present study. The results of the present study demonstrated that the median PFS (mPFS) was 8.1 months for all patients, ranging from 3.3‑10.6 months. Patients receiving pyrotinib as second‑line therapy exhibited a longer mPFS of 8.5 months compared with those receiving it as third‑ or higher‑line therapy (mPFS, 5.9 months). In 17 patients with brain metastases, mPFS was 7.3 months, ranging from 4.8‑10.1 months. The results of the present study also demonstrated that the ORR for the 48 patients was 33.3%. Notably, diarrhea was the most common grade 3‑4 adverse event, occurring in 22.9% of patients, followed by neutropenia (6.3%), leukopenia (4.2%) and anemia (4.2%). Collectively, the results of the present study indicated that pyrotinib‑based treatment is effective for patients with HER2+ ABC, including those who have previously been treated with trastuzumab. Thus, the combination of pyrotinib with albumin‑bound paclitaxel is recommended due to high levels of efficacy, convenience and tolerability.
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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Zheng L, Kong F, Tian X, Zhang S and Pu P: ​Efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel for the treatment of HER2‑positive advanced breast cancer: A real‑world study. Oncol Lett 26: 312, 2023.
APA
Yang, L., Zheng, L., Kong, F., Tian, X., Zhang, S., & Pu, P. (2023). ​Efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel for the treatment of HER2‑positive advanced breast cancer: A real‑world study. Oncology Letters, 26, 312. https://doi.org/10.3892/ol.2023.13898
MLA
Yang, L., Zheng, L., Kong, F., Tian, X., Zhang, S., Pu, P."​Efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel for the treatment of HER2‑positive advanced breast cancer: A real‑world study". Oncology Letters 26.1 (2023): 312.
Chicago
Yang, L., Zheng, L., Kong, F., Tian, X., Zhang, S., Pu, P."​Efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel for the treatment of HER2‑positive advanced breast cancer: A real‑world study". Oncology Letters 26, no. 1 (2023): 312. https://doi.org/10.3892/ol.2023.13898
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Zheng L, Kong F, Tian X, Zhang S and Pu P: ​Efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel for the treatment of HER2‑positive advanced breast cancer: A real‑world study. Oncol Lett 26: 312, 2023.
APA
Yang, L., Zheng, L., Kong, F., Tian, X., Zhang, S., & Pu, P. (2023). ​Efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel for the treatment of HER2‑positive advanced breast cancer: A real‑world study. Oncology Letters, 26, 312. https://doi.org/10.3892/ol.2023.13898
MLA
Yang, L., Zheng, L., Kong, F., Tian, X., Zhang, S., Pu, P."​Efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel for the treatment of HER2‑positive advanced breast cancer: A real‑world study". Oncology Letters 26.1 (2023): 312.
Chicago
Yang, L., Zheng, L., Kong, F., Tian, X., Zhang, S., Pu, P."​Efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel for the treatment of HER2‑positive advanced breast cancer: A real‑world study". Oncology Letters 26, no. 1 (2023): 312. https://doi.org/10.3892/ol.2023.13898
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