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Encapsulated papillary carcinoma of the breast: A single institution experience

  • Authors:
    • Liang Xu
    • Qixin Mao
    • Qiuming Liu
    • Yufeng Gao
    • Lihua Luo
    • Chungen Guo
    • Wei Qu
    • Ningning Yan
    • Yali Cao
  • View Affiliations / Copyright

    Affiliations: Prevention and Cure Center of Breast Disease, The Third Hospital of Nanchang City, Nanchang, Jiangxi 330009, P.R. China, Department of Breast Disease, Henan Breast Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450002, P.R. China, Department of Medical Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450002, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 459
    |
    Published online on: September 7, 2023
       https://doi.org/10.3892/ol.2023.14046
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Abstract

Encapsulated papillary carcinoma (EPC) is a relatively rare form of breast cancer. To date, no evidence‑based guidelines for the treatment of EPC have been established. Between January 2015 and December 2021, patients with histologically confirmed EPC of the breast were recorded in a database by The Third Hospital of Nanchang City (Nanchang, China). A total of 46 patients with EPC were retrieved from the database. Age at diagnosis ranged from 41‑88 years (median age, 62 years). A total of 21 of these patients had pure EPC, 6 patients had EPC associated with ductal carcinoma in situ and 19 patients had EPC associated with invasive carcinoma. The majority of EPC cases were low nuclear grade, hormone receptor‑positive and human epidermal growth factor receptor‑2‑negative. Additionally, myoepithelial cells were always absent in the papillae of the EPC. All patients underwent lumpectomy or mastectomy with sentinel lymph node biopsy, and almost all of the patients received adjuvant hormonal therapy. Adjuvant chemotherapy was only suggested to 4 patients who were diagnosed with axillary lymph node involvement. Subsequently, the clinicopathological features of non‑invasive EPC were compared with invasive EPC. The results indicated that larger tumor sizes and axillary lymph node metastases were more common in invasive tumors. During the follow‑up, only 2 patients with invasive EPC experienced recurrence or metastasis. In conclusion, a substantial proportion of invasive EPC cases display aggressive characteristics and metastatic potential, despite it being considered a subtype of carcinoma in situ with excellent prognosis, and local surgical resection is the initial method of treatment. Therefore, adjuvant endocrine therapy, radiotherapy and chemotherapy should be considered in select patients, especially in those diagnosed with invasive EPC tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Xu L, Mao Q, Liu Q, Gao Y, Luo L, Guo C, Qu W, Yan N and Cao Y: Encapsulated papillary carcinoma of the breast: A single institution experience. Oncol Lett 26: 459, 2023.
APA
Xu, L., Mao, Q., Liu, Q., Gao, Y., Luo, L., Guo, C. ... Cao, Y. (2023). Encapsulated papillary carcinoma of the breast: A single institution experience. Oncology Letters, 26, 459. https://doi.org/10.3892/ol.2023.14046
MLA
Xu, L., Mao, Q., Liu, Q., Gao, Y., Luo, L., Guo, C., Qu, W., Yan, N., Cao, Y."Encapsulated papillary carcinoma of the breast: A single institution experience". Oncology Letters 26.4 (2023): 459.
Chicago
Xu, L., Mao, Q., Liu, Q., Gao, Y., Luo, L., Guo, C., Qu, W., Yan, N., Cao, Y."Encapsulated papillary carcinoma of the breast: A single institution experience". Oncology Letters 26, no. 4 (2023): 459. https://doi.org/10.3892/ol.2023.14046
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Mao Q, Liu Q, Gao Y, Luo L, Guo C, Qu W, Yan N and Cao Y: Encapsulated papillary carcinoma of the breast: A single institution experience. Oncol Lett 26: 459, 2023.
APA
Xu, L., Mao, Q., Liu, Q., Gao, Y., Luo, L., Guo, C. ... Cao, Y. (2023). Encapsulated papillary carcinoma of the breast: A single institution experience. Oncology Letters, 26, 459. https://doi.org/10.3892/ol.2023.14046
MLA
Xu, L., Mao, Q., Liu, Q., Gao, Y., Luo, L., Guo, C., Qu, W., Yan, N., Cao, Y."Encapsulated papillary carcinoma of the breast: A single institution experience". Oncology Letters 26.4 (2023): 459.
Chicago
Xu, L., Mao, Q., Liu, Q., Gao, Y., Luo, L., Guo, C., Qu, W., Yan, N., Cao, Y."Encapsulated papillary carcinoma of the breast: A single institution experience". Oncology Letters 26, no. 4 (2023): 459. https://doi.org/10.3892/ol.2023.14046
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