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Article

Comparison of the outcomes of patients with primary central nervous system lymphoma between the neurosurgery and hematology/oncology departments based on the relative dose intensity of methotrexate

  • Authors:
    • Hiroki Hosoi
    • Tadashi Okamura
    • Junya Fukai
    • Yoshikazu Hori
    • Shogo Murata
    • Toshiki Mushino
    • Naoyuki Nakao
    • Takashi Sonoki
  • View Affiliations / Copyright

    Affiliations: Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641‑8509, Japan, Department of Neurological Surgery, Wakayama Medical University, Wakayama 641‑8509, Japan
  • Article Number: 469
    |
    Published online on: September 19, 2023
       https://doi.org/10.3892/ol.2023.14056
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Abstract

Primary central nervous system lymphoma (PCNSL) is an extranodal type of lymphoma, which is treated with methotrexate (MTX)‑based induction therapy. Although PCNSL is a hematological malignancy, patients with PCNSL may be treated at neurosurgery or hematology/oncology departments; however, the outcomes of PCNSL treatment have not been compared between these two departments. The present study compared the outcomes of 26 patients with newly diagnosed PCNSL that were treated at the Department of Neurological Surgery or Department of Hematology/Oncology (Wakayama Medical University Hospital, Wakayama, Japan) between January 2011 and December 2021. The relative dose intensity (RDI) and relative treatment intensity of MTX were assessed as indicators of the intensity of chemotherapy. The median RDI of MTX was 67 and 93% in the neurosurgery and hematology/oncology groups, respectively (P<0.001). The proportion of patients that achieved a complete response after high‑dose MTX‑based therapy was significantly higher in the hematology/oncology group than in the neurosurgery group (P=0.038). The estimated 2‑year overall survival was 72 and 100% in the neurosurgery and hematology/oncology groups, respectively (P=0.046). As with the difference in the outcomes observed between pediatrics and hematology departments for adolescents with acute lymphoblastic leukemia, the outcomes of patients with PCNSL may differ between neurosurgery and hematology/oncology departments.
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Copy and paste a formatted citation
Spandidos Publications style
Hosoi H, Okamura T, Fukai J, Hori Y, Murata S, Mushino T, Nakao N and Sonoki T: Comparison of the outcomes of patients with primary central nervous system lymphoma between the neurosurgery and hematology/oncology departments based on the relative dose intensity of methotrexate. Oncol Lett 26: 469, 2023.
APA
Hosoi, H., Okamura, T., Fukai, J., Hori, Y., Murata, S., Mushino, T. ... Sonoki, T. (2023). Comparison of the outcomes of patients with primary central nervous system lymphoma between the neurosurgery and hematology/oncology departments based on the relative dose intensity of methotrexate. Oncology Letters, 26, 469. https://doi.org/10.3892/ol.2023.14056
MLA
Hosoi, H., Okamura, T., Fukai, J., Hori, Y., Murata, S., Mushino, T., Nakao, N., Sonoki, T."Comparison of the outcomes of patients with primary central nervous system lymphoma between the neurosurgery and hematology/oncology departments based on the relative dose intensity of methotrexate". Oncology Letters 26.5 (2023): 469.
Chicago
Hosoi, H., Okamura, T., Fukai, J., Hori, Y., Murata, S., Mushino, T., Nakao, N., Sonoki, T."Comparison of the outcomes of patients with primary central nervous system lymphoma between the neurosurgery and hematology/oncology departments based on the relative dose intensity of methotrexate". Oncology Letters 26, no. 5 (2023): 469. https://doi.org/10.3892/ol.2023.14056
Copy and paste a formatted citation
x
Spandidos Publications style
Hosoi H, Okamura T, Fukai J, Hori Y, Murata S, Mushino T, Nakao N and Sonoki T: Comparison of the outcomes of patients with primary central nervous system lymphoma between the neurosurgery and hematology/oncology departments based on the relative dose intensity of methotrexate. Oncol Lett 26: 469, 2023.
APA
Hosoi, H., Okamura, T., Fukai, J., Hori, Y., Murata, S., Mushino, T. ... Sonoki, T. (2023). Comparison of the outcomes of patients with primary central nervous system lymphoma between the neurosurgery and hematology/oncology departments based on the relative dose intensity of methotrexate. Oncology Letters, 26, 469. https://doi.org/10.3892/ol.2023.14056
MLA
Hosoi, H., Okamura, T., Fukai, J., Hori, Y., Murata, S., Mushino, T., Nakao, N., Sonoki, T."Comparison of the outcomes of patients with primary central nervous system lymphoma between the neurosurgery and hematology/oncology departments based on the relative dose intensity of methotrexate". Oncology Letters 26.5 (2023): 469.
Chicago
Hosoi, H., Okamura, T., Fukai, J., Hori, Y., Murata, S., Mushino, T., Nakao, N., Sonoki, T."Comparison of the outcomes of patients with primary central nervous system lymphoma between the neurosurgery and hematology/oncology departments based on the relative dose intensity of methotrexate". Oncology Letters 26, no. 5 (2023): 469. https://doi.org/10.3892/ol.2023.14056
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