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Article

The impact of primary region resection on the therapeutic outcome of combination regimens for metastatic renal cell carcinoma

  • Authors:
    • Jun Teishima
    • Takuto Hara
    • Taisuke Tobe
    • Junichiro Hirata
    • Hideto Ueki
    • Naoto Wakita
    • Yusuke Shiraishi
    • Yasuyoshi Okamura
    • Yukari Bando
    • Tomoaki Terakawa
    • Junya Furukawa
    • Ken-Ιchi Harada
    • Yuzo Nakano
    • Masato Fujisawa
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Division of Urology, Kobe University, Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan, Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807‑8555, Japan
  • Article Number: 470
    |
    Published online on: September 20, 2023
       https://doi.org/10.3892/ol.2023.14057
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Abstract

The present study aimed to clarify the relationship between the therapeutic outcome of combination regimens, including immune checkpoint inhibitors (ICIs) and/or tyrosine kinase inhibitors (TKIs), and cytoreductive nephrectomy (CN) for metastatic renal cell carcinoma (mRCC). The present study retrospectively assessed the association between treatment efficacy and prognosis with or without CN, and the timing of CN in 151 patients treated with combination regimens for mRCC who were categorized as intermediate/poor risk. The first‑line regimens included the ICI‑ICI and ICI‑TKI regimens in 98 and 53 cases, respectively. In patients with recurrence after radical surgery (n=66), the 50% PFS times of the ICI‑ICI and the ICI‑TKI groups were 33.6 months and not reached (NR) (P=0.4032), respectively, and the 50% OS times were 53.7 months and NR (P=0.6886), respectively. Among the 38 patients with metastasis from the initial diagnosis who underwent upfront CN, the 50% PFS times of the ICI‑ICI and the ICI‑TKI groups were 10.5 and 8.2 months (P=0.5806), respectively, and the 50% OS times were NR and 15.8 months (P=0.0587), respectively. Among the 51 patients who did not receive upfront CN, the 50% PFS time of the ICI‑TKI group was significantly higher than that in the ICI‑ICI group (4.1 months and NR, respectively; P=0.0210), and the 50% OS times were 29.8 months and NR (P=0.7343), respectively. In conclusion, according to the analysis of real‑world data, good therapeutic efficacy can be achieved with any regimen in patients with recurrence after radical surgery. In addition, improved results could be achieved through treatment with ICI‑TKI in patients without upfront CN.
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Copy and paste a formatted citation
Spandidos Publications style
Teishima J, Hara T, Tobe T, Hirata J, Ueki H, Wakita N, Shiraishi Y, Okamura Y, Bando Y, Terakawa T, Terakawa T, et al: The impact of primary region resection on the therapeutic outcome of combination regimens for metastatic renal cell carcinoma. Oncol Lett 26: 470, 2023.
APA
Teishima, J., Hara, T., Tobe, T., Hirata, J., Ueki, H., Wakita, N. ... Fujisawa, M. (2023). The impact of primary region resection on the therapeutic outcome of combination regimens for metastatic renal cell carcinoma. Oncology Letters, 26, 470. https://doi.org/10.3892/ol.2023.14057
MLA
Teishima, J., Hara, T., Tobe, T., Hirata, J., Ueki, H., Wakita, N., Shiraishi, Y., Okamura, Y., Bando, Y., Terakawa, T., Furukawa, J., Harada, K., Nakano, Y., Fujisawa, M."The impact of primary region resection on the therapeutic outcome of combination regimens for metastatic renal cell carcinoma". Oncology Letters 26.5 (2023): 470.
Chicago
Teishima, J., Hara, T., Tobe, T., Hirata, J., Ueki, H., Wakita, N., Shiraishi, Y., Okamura, Y., Bando, Y., Terakawa, T., Furukawa, J., Harada, K., Nakano, Y., Fujisawa, M."The impact of primary region resection on the therapeutic outcome of combination regimens for metastatic renal cell carcinoma". Oncology Letters 26, no. 5 (2023): 470. https://doi.org/10.3892/ol.2023.14057
Copy and paste a formatted citation
x
Spandidos Publications style
Teishima J, Hara T, Tobe T, Hirata J, Ueki H, Wakita N, Shiraishi Y, Okamura Y, Bando Y, Terakawa T, Terakawa T, et al: The impact of primary region resection on the therapeutic outcome of combination regimens for metastatic renal cell carcinoma. Oncol Lett 26: 470, 2023.
APA
Teishima, J., Hara, T., Tobe, T., Hirata, J., Ueki, H., Wakita, N. ... Fujisawa, M. (2023). The impact of primary region resection on the therapeutic outcome of combination regimens for metastatic renal cell carcinoma. Oncology Letters, 26, 470. https://doi.org/10.3892/ol.2023.14057
MLA
Teishima, J., Hara, T., Tobe, T., Hirata, J., Ueki, H., Wakita, N., Shiraishi, Y., Okamura, Y., Bando, Y., Terakawa, T., Furukawa, J., Harada, K., Nakano, Y., Fujisawa, M."The impact of primary region resection on the therapeutic outcome of combination regimens for metastatic renal cell carcinoma". Oncology Letters 26.5 (2023): 470.
Chicago
Teishima, J., Hara, T., Tobe, T., Hirata, J., Ueki, H., Wakita, N., Shiraishi, Y., Okamura, Y., Bando, Y., Terakawa, T., Furukawa, J., Harada, K., Nakano, Y., Fujisawa, M."The impact of primary region resection on the therapeutic outcome of combination regimens for metastatic renal cell carcinoma". Oncology Letters 26, no. 5 (2023): 470. https://doi.org/10.3892/ol.2023.14057
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