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A retrospective study of transarterial chemoembolization (TACE) combined with lenvatinib compared with TACE monotherapy for BCLC B2 stage hepatocellular carcinoma

  • Authors:
    • Junning Liu
    • Shu Yan
    • Guangnian Zhang
    • Linfeng Yang
    • Song Wei
    • Pengsheng Yi
  • View Affiliations / Copyright

    Affiliations: Department of Hepato‑Biliary‑Pancreas II, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 507
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    Published online on: October 10, 2023
       https://doi.org/10.3892/ol.2023.14094
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Abstract

The present study aimed to compare the efficacy and safety of combination therapy with lenvatinib (Len) plus transarterial chemoembolization (TACE) and TACE alone in patients with Barcelona Clinic Liver Cancer (BCLC) B2 stage hepatocellular carcinoma (HCC). A total of 66 patients with BCLC B2 stage HCC were retrospectively reviewed in the present study, of which 34 patients received Len + TACE, while 32 patients received TACE alone between May 2018 and May 2020. Survival outcome, tumor response and adverse events (AEs) were compared between the two treatment groups. The 6‑month, 1‑ and 2‑year overall survival (OS) rates were significantly higher in the Len + TACE group (97.1, 85.3 and 76.3%, respectively) compared with those in the TACE group [(93.8, 81.1 and 45.4%, respectively); hazard ratio (HR), 0.395; 95% confidence interval (CI), 0.180‑0.867; P=0.023], but no significant difference in progression‑free survival rate was observed between the two groups (HR, 0.815; 95% CI, 0.437‑1.520; P=0.510). Patients receiving Len + TACE demonstrated a higher objective response rate compared with those receiving TACE alone (64.7 vs. 34.4%; P=0.014). Therefore, Len + TACE combination therapy was associated with increased OS and tumor response compared with that of TACE monotherapy in patients with BCLC B2 stage HCC. However, large‑scale, multicenter, prospective studies are needed to further confirm these results.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Yan S, Zhang G, Yang L, Wei S and Yi P: A retrospective study of transarterial chemoembolization (TACE) combined with lenvatinib compared with TACE monotherapy for BCLC B2 stage hepatocellular carcinoma. Oncol Lett 26: 507, 2023.
APA
Liu, J., Yan, S., Zhang, G., Yang, L., Wei, S., & Yi, P. (2023). A retrospective study of transarterial chemoembolization (TACE) combined with lenvatinib compared with TACE monotherapy for BCLC B2 stage hepatocellular carcinoma. Oncology Letters, 26, 507. https://doi.org/10.3892/ol.2023.14094
MLA
Liu, J., Yan, S., Zhang, G., Yang, L., Wei, S., Yi, P."A retrospective study of transarterial chemoembolization (TACE) combined with lenvatinib compared with TACE monotherapy for BCLC B2 stage hepatocellular carcinoma". Oncology Letters 26.6 (2023): 507.
Chicago
Liu, J., Yan, S., Zhang, G., Yang, L., Wei, S., Yi, P."A retrospective study of transarterial chemoembolization (TACE) combined with lenvatinib compared with TACE monotherapy for BCLC B2 stage hepatocellular carcinoma". Oncology Letters 26, no. 6 (2023): 507. https://doi.org/10.3892/ol.2023.14094
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Yan S, Zhang G, Yang L, Wei S and Yi P: A retrospective study of transarterial chemoembolization (TACE) combined with lenvatinib compared with TACE monotherapy for BCLC B2 stage hepatocellular carcinoma. Oncol Lett 26: 507, 2023.
APA
Liu, J., Yan, S., Zhang, G., Yang, L., Wei, S., & Yi, P. (2023). A retrospective study of transarterial chemoembolization (TACE) combined with lenvatinib compared with TACE monotherapy for BCLC B2 stage hepatocellular carcinoma. Oncology Letters, 26, 507. https://doi.org/10.3892/ol.2023.14094
MLA
Liu, J., Yan, S., Zhang, G., Yang, L., Wei, S., Yi, P."A retrospective study of transarterial chemoembolization (TACE) combined with lenvatinib compared with TACE monotherapy for BCLC B2 stage hepatocellular carcinoma". Oncology Letters 26.6 (2023): 507.
Chicago
Liu, J., Yan, S., Zhang, G., Yang, L., Wei, S., Yi, P."A retrospective study of transarterial chemoembolization (TACE) combined with lenvatinib compared with TACE monotherapy for BCLC B2 stage hepatocellular carcinoma". Oncology Letters 26, no. 6 (2023): 507. https://doi.org/10.3892/ol.2023.14094
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