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Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma

  • Authors:
    • Yi-Fan Wang
    • Yu-Ning Hu
    • Ze-Fan Shen
    • Chang-Feng Zhao
    • Kun Liu
    • Heng Wang
    • Qi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Urology and Nephrology Center, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310000, P.R. China, Graduate Department, The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, P.R. China, Graduate Department, Bengbu Medical College, Bengbu, Anhui 233000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 524
    |
    Published online on: October 23, 2023
       https://doi.org/10.3892/ol.2023.14111
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Abstract

Ephrin A3 (EFNA3) is a member of the Eph/ephrin tyrosine kinase family, which is associated with multiple signaling pathways involved in cell growth and tumor cell metastasis. Aberrant regulation of EFNA3 is associated with the occurrence and development of various types of cancer. However, despite the high incidence of EFNA3 upregulation in cancer, studies concerning EFNA3 in urothelial carcinoma have not, to the best of our knowledge, been conducted. In the present study, bioinformatics analyses using data from multiple online databases were performed to confirm the upregulation of EFNA3 in bladder cancer. The co‑expression gene set of EFNA3 and enriched signaling pathways were also analyzed. In addition, immunohistochemistry was conducted to detect EFNA3 expression in 491 clinically confirmed bladder urothelial carcinoma samples and 80 non‑cancerous bladder tissues. Kaplan‑Meier survival analysis, binary logistic regression analysis, and Cox regression analysis were conducted to confirm the validity of EFNA3 in predicting patient prognosis and its significance in clinical pathology. Statistical analysis demonstrated a significant association between EFNA3 expression levels with tumor size, lymph node metastasis, distant metastasis, and pathological grade. In conclusion, high EFNA3 expression may be a potential biomarker that indicates bladder tumor occurrence and patient prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Hu Y, Shen Z, Zhao C, Liu K, Wang H and Zhang Q: Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma. Oncol Lett 26: 524, 2023.
APA
Wang, Y., Hu, Y., Shen, Z., Zhao, C., Liu, K., Wang, H., & Zhang, Q. (2023). Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma. Oncology Letters, 26, 524. https://doi.org/10.3892/ol.2023.14111
MLA
Wang, Y., Hu, Y., Shen, Z., Zhao, C., Liu, K., Wang, H., Zhang, Q."Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma". Oncology Letters 26.6 (2023): 524.
Chicago
Wang, Y., Hu, Y., Shen, Z., Zhao, C., Liu, K., Wang, H., Zhang, Q."Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma". Oncology Letters 26, no. 6 (2023): 524. https://doi.org/10.3892/ol.2023.14111
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Hu Y, Shen Z, Zhao C, Liu K, Wang H and Zhang Q: Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma. Oncol Lett 26: 524, 2023.
APA
Wang, Y., Hu, Y., Shen, Z., Zhao, C., Liu, K., Wang, H., & Zhang, Q. (2023). Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma. Oncology Letters, 26, 524. https://doi.org/10.3892/ol.2023.14111
MLA
Wang, Y., Hu, Y., Shen, Z., Zhao, C., Liu, K., Wang, H., Zhang, Q."Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma". Oncology Letters 26.6 (2023): 524.
Chicago
Wang, Y., Hu, Y., Shen, Z., Zhao, C., Liu, K., Wang, H., Zhang, Q."Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma". Oncology Letters 26, no. 6 (2023): 524. https://doi.org/10.3892/ol.2023.14111
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