Open Access

Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma

  • Authors:
    • Yi-Fan Wang
    • Yu-Ning Hu
    • Ze-Fan Shen
    • Chang-Feng Zhao
    • Kun Liu
    • Heng Wang
    • Qi Zhang
  • View Affiliations

  • Published online on: October 23, 2023     https://doi.org/10.3892/ol.2023.14111
  • Article Number: 524
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Ephrin A3 (EFNA3) is a member of the Eph/ephrin tyrosine kinase family, which is associated with multiple signaling pathways involved in cell growth and tumor cell metastasis. Aberrant regulation of EFNA3 is associated with the occurrence and development of various types of cancer. However, despite the high incidence of EFNA3 upregulation in cancer, studies concerning EFNA3 in urothelial carcinoma have not, to the best of our knowledge, been conducted. In the present study, bioinformatics analyses using data from multiple online databases were performed to confirm the upregulation of EFNA3 in bladder cancer. The co‑expression gene set of EFNA3 and enriched signaling pathways were also analyzed. In addition, immunohistochemistry was conducted to detect EFNA3 expression in 491 clinically confirmed bladder urothelial carcinoma samples and 80 non‑cancerous bladder tissues. Kaplan‑Meier survival analysis, binary logistic regression analysis, and Cox regression analysis were conducted to confirm the validity of EFNA3 in predicting patient prognosis and its significance in clinical pathology. Statistical analysis demonstrated a significant association between EFNA3 expression levels with tumor size, lymph node metastasis, distant metastasis, and pathological grade. In conclusion, high EFNA3 expression may be a potential biomarker that indicates bladder tumor occurrence and patient prognosis.
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December-2023
Volume 26 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang Y, Hu Y, Shen Z, Zhao C, Liu K, Wang H and Zhang Q: Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma. Oncol Lett 26: 524, 2023.
APA
Wang, Y., Hu, Y., Shen, Z., Zhao, C., Liu, K., Wang, H., & Zhang, Q. (2023). Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma. Oncology Letters, 26, 524. https://doi.org/10.3892/ol.2023.14111
MLA
Wang, Y., Hu, Y., Shen, Z., Zhao, C., Liu, K., Wang, H., Zhang, Q."Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma". Oncology Letters 26.6 (2023): 524.
Chicago
Wang, Y., Hu, Y., Shen, Z., Zhao, C., Liu, K., Wang, H., Zhang, Q."Clinicopathological and prognostic significance of Ephrin A3 in bladder urothelial carcinoma". Oncology Letters 26, no. 6 (2023): 524. https://doi.org/10.3892/ol.2023.14111