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Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer

  • Authors:
    • Takashi Nakayama
    • Ryo Saito
    • Shinji Furuya
    • Katsutoshi Shoda
    • Suguru Maruyma
    • Koichi Takiguchi
    • Kensuke Shiraishi
    • Hidenori Akaike
    • Yoshihiko Kawaguchi
    • Hidetake Amemiya
    • Hiromichi Kawaida
    • Nagaharu Tsukiji
    • Toshiaki Shirai
    • Hideyuki Shinmori
    • Masami Yamamoto
    • Sachiyo Nomura
    • Tetsuya Tsukamoto
    • Katsue Suzuki‑Inoue
    • Daisuke Ichikawa
  • View Affiliations / Copyright

    Affiliations: First Department of Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan, Department of Clinical and Laboratory, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan, Department of Biotechnology, Faculty of Life and Environmental Science, University of Yamanashi, Kofu, Yamanashi 400‑8510, Japan, Laboratory of Physiological Pathology, Nippon Veterinary and Life Science University, Tokyo 180‑8602, Japan, Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113‑8655, Japan, Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470‑1192, Japan
    Copyright: © Nakayama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 538
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    Published online on: November 1, 2023
       https://doi.org/10.3892/ol.2023.14125
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Abstract

Platelets form complexes with gastric cancer (GC) cells via direct contact, enhancing their malignant behavior. In the present study, the molecules responsible for GC cell‑platelet interactions were examined and their therapeutic application in inhibiting the peritoneal dissemination of GC was investigated. First, the inhibitory effects of various candidate surface molecules were investigated on platelets and GC cells, such as C‑type lectin‑like receptor 2 (CLEC‑2), glycoprotein VI (GPVI) and integrin αIIbβ3, in the platelet‑induced enhancement of GC cell malignant potential. Second, the therapeutic effects of molecules responsible for the development and progression of GC were investigated in a mouse model of peritoneal dissemination. Platelet‑induced enhancement of the migratory ability of GC cells was markedly inhibited by an anti‑GPVI antibody and inhibitor of galectin‑3, a GPVI ligand. However, neither the CLEC‑2 inhibitor nor the integrin‑blocking peptide significantly suppressed this enhanced migratory ability. In experiments using mouse GC cells and platelets, the migratory and invasive abilities enhanced by platelets were significantly suppressed by the anti‑GPVI antibody and galectin‑3 inhibitor. Furthermore, in vivo analyses demonstrated that the platelet‑induced enhancement of peritoneal dissemination was significantly suppressed by the coadministration of anti‑GPVI antibody and galectin‑3 inhibitor, and was nearly eliminated by the combined treatment. The inhibition of adhesion resulting from GPVI‑galectin‑3 interaction may be a promising therapeutic strategy for preventing peritoneal dissemination in patients with GC.
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View References

1 

Labelle M, Begum S and Hynes RO: Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell. 20:576–590. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Rothwell PM, Wilson M, Price JF, Belch JFF, Mead TW and Mehta Z: Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials. Lancet. 379:1591–1601. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Shirai T, Inoue O, Tamura S, Tsukiji N, Sasaki T, Endo H, Satoh K, Osada M, Sato-Uchida H, Fujii H, et al: C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice. J Thromb Haemost. 15:513–525. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Saito R, Shoda K, Maruyama S, Yamamoto A, Takiguchi K, Furuya S, Hosomura N, Akaike H, Kawaguchi Y, Amemiya H, et al: Platelets enhance malignant behaviours of gastric cancer cells via direct contacts. Br J Cancer. 124:570–573. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Suzuki-Inoue K, Fuller GL, García A, Eble JA, Pöhlmann S, Inoue O, Gartner TK, Hughan SC, Pearce AC, Laing GD, et al: A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood. 107:542–549. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Suzuki-Inoue K, Inoue O and Ozaki Y: Novel platelet activation receptor CLEC-2: From discovery to prospects. J Thromb Haemost. 9 (Suppl 1):S44–S55. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Suzuki-Inoue K: Roles of the CLEC-2-podoplanin interaction in tumor progression. Platelets. 1–7. 2018.(Epub ahead of print). PubMed/NCBI

8 

Breiteneder-Geleff S, Soleiman A, Kowalski H, Horvat R, Amann G, Kriehuber E, Diem K, Weninger W, Tschachler E, Alitalo K and Kerjaschki D: Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium. Am J Pathol. 154:385–394. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Fujita N and Takagi S: The impact of Aggrus/podoplanin on platelet aggregation and tumour metastasis. J Biochem. 152:407–413. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Moroi M, Jung SM, Okuma M and Shinmyozu K: A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. J Clin Invest. 84:1440–1445. 1989. View Article : Google Scholar : PubMed/NCBI

11 

Sugiyama T, Okuma M, Ushikubi F, Sensaki S, Kanaji K and Uchino H: A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. Blood. 69:1712–1720. 1987. View Article : Google Scholar : PubMed/NCBI

12 

Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, Burkard P, Shityakov S, Schonhart C, Stegner D, Remer K, Nurden P, Nurden AT, et al: Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3. Blood. 135:1146–1160. 2020.PubMed/NCBI

13 

Ma YQ, Qin J and Plow EF: Platelet integrin alpha(IIb)beta(3): Activation mechanisms. J Thromb Haemost. 5:1345–1352. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Zhang C, Liu Y, Gao Y, Shen J, Zheng S, Wei M and Zeng X: Modified heparins inhibit integrin alpha(IIb)beta(3) mediated adhesion of melanoma cells to platelets in vitro and in vivo. Int J Cancer. 125:2058–2065. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Arita T, Ichikawa D, Konishi H, Komatsu S, Shinozaki A, Hiramoto H, Hamada J, Shoda K, Kawaguchi T, Hirajima S, et al: Increase in peritoneal recurrence induced by intraoperative hemorrhage in gastrectomy. Ann Surg Oncol. 22:758–764. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Yamamoto M, Nomura S, Hosoi A, Nagaoka K, Iino T, Yasuda T, Saito T, Matsushita H, Uchida E, Seto Y, et al: Established gastric cancer cell lines transplantable into C57BL/6 mice show fibroblast growth factor receptor 4 promotion of tumor growth. Cancer Sci. 109:1480–1492. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Huan Y, Caixia L and Wei Z: Expression of galectin-3 in mouse endometrium and its effect during embryo implantation. Reprod Biomed Online. 24:116–122. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Satoh K, Fukasawa I, Kanemaru K, Yoda S, Kimura Y, Inoue O, Ohta M, Kinouchi H and Ozaki Y: Platelet aggregometry in the presence of PGE(1) provides a reliable method for cilostazol monitoring. Thromb Res. 130:616–621. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Suzuki-Inoue K, Inoue O, Frampton J and Watson SP: Murine GPVI stimulates weak integrin activation in PLCgamma2-/-platelets: Involvement of PLCgamma1 and PI3-kinase. Blood. 102:1367–1373. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Inoue O, Hokamura K, Shirai T, Osada M, Tsukiji N, Hatakeyama K, Umemura K, Asada Y, Suzuki-Inoue K and Ozaki Y: Vascular smooth muscle cells stimulate platelets and facilitate thrombus formation through platelet CLEC-2: Implications in atherothrombosis. PLoS One. 10:e01393572015. View Article : Google Scholar : PubMed/NCBI

22 

Tsukiji N, Osada M, Sasaki T, Shirai T, Satoh K, Inoue O, Umetani N, Mochizuki C, Saito T, Kojima S, et al: Cobalt hematoporphyrin inhibits CLEC-2-podoplanin interaction, tumor metastasis, and arterial/venous thrombosis in mice. Blood Adv. 2:2214–2225. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Kawai S, Takagi Y, Kaneko S and Kurosawa T: Effect of three types of mixed anesthetic agents alternate to ketamine in mice. Exp Anim. 60:481–487. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Narikiyo K, Mizuguchi R, Ajima A, Shiozaki M, Hamanaka H, Johansen JP, Mori K and Yoshihara Y: The claustrum coordinates cortical slow-wave activity. Nat Neurosci. 23:741–753. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Olajide OJ, Gbadamosi IT, Yawson EO, Arogundade T, Lewu FS, Ogunrinola KY, Adigun OO, Bamisi O, Lambe E, Arietarhire LO, et al: Hippocampal degeneration and behavioral impairment during alzheimer-like pathogenesis involves glutamate excitotoxicity. J mol Neurosci. 71:1205–1220. 2021. View Article : Google Scholar : PubMed/NCBI

26 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Suzuki-Inoue K: Platelets and cancer-associated thrombosis: Focusing on the platelet activation receptor CLEC-2 and podoplanin. Blood. 134:1912–1918. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Hwang BO, Park SY, Cho ES, Zhang X, Lee SK, Ahn HJ, Chun KS, Chung WY and Song NY: Platelet CLEC2-podoplanin axis as a promising target for oral cancer treatment. Front Immunol. 12:8076002021. View Article : Google Scholar : PubMed/NCBI

29 

Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y and Suzuki-Inoue K: Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis. J Thromb Haemost. 16:960–972. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Huang J, Li X, Shi X, Zhu M, Wang J, Huang S, Huang X, Wang H, Li L, Deng H, et al: Platelet integrin αIIbβ3: Signal transduction, regulation, and its therapeutic targeting. J Hematol Oncol. 12:262019. View Article : Google Scholar : PubMed/NCBI

31 

Obermann WMJ, Brockhaus K and Eble JA: Platelets, constant and cooperative companions of sessile and disseminating tumor cells, crucially contribute to the tumor microenvironment. Front Cell Dev Biol. 9:6745532021. View Article : Google Scholar : PubMed/NCBI

32 

Kitayama J, Ishigami H, Yamaguchi H, Sakuma Y, Horie H, Hosoya Y, Lefor AK and Sata N: Treatment of patients with peritoneal metastases from gastric cancer. Ann Gastroenterol Surg. 2:116–123. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Huang B, Rouvelas I and Nilsson M: Gastric and gastroesophageal junction cancer: Risk factors and prophylactic treatments for prevention of peritoneal recurrence after curative intent surgery. Ann Gastroenterol Surg. 6:474–485. 2022. View Article : Google Scholar : PubMed/NCBI

34 

Kamei T, Kitayama J, Yamashita H and Nagawa H: Intraoperative blood loss is a critical risk factor for peritoneal recurrence after curative resection of advanced gastric cancer. World J Surg. 33:1240–1246. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Miyashita T, Tajima H, Gabata R, Okazaki M, Shimbashi H, Ohbatake Y, Okamoto K, Nakanuma S, Sakai S, Makino I, et al: Impact of extravasated platelet activation and podoplanin-positive cancer-associated fibroblasts in pancreatic cancer stroma. Anticancer Res. 39:5565–5572. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Yamaguchi T, Fushida S, Kinoshita J, Okazaki M, Ishikawa S, Ohbatake Y, Terai S, Okamoto K, Nakanuma S, Makino I, et al: Extravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid-derived suppressor cells in gastric cancer with peritoneal metastasis. Oncol Lett. 20:1879–1887. 2020. View Article : Google Scholar : PubMed/NCBI

37 

Lee JJ, Hsu YC, Li YS and Cheng SP: Galectin-3 inhibitors suppress anoikis resistance and invasive capacity in thyroid cancer cells. Int J Endocrinol. 2021:55834912021. View Article : Google Scholar : PubMed/NCBI

38 

World Medical Association, . World medical association declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA. 310:2191–2194. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Percie du Sert N, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, et al: Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol. 18:e30004112020. View Article : Google Scholar : PubMed/NCBI

40 

National Research Council (US), . Committee for the update of the guide for the care and use of laboratory animals: Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press; Washington, DC: 2011

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Copy and paste a formatted citation
Spandidos Publications style
Nakayama T, Saito R, Furuya S, Shoda K, Maruyma S, Takiguchi K, Shiraishi K, Akaike H, Kawaguchi Y, Amemiya H, Amemiya H, et al: Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer. Oncol Lett 26: 538, 2023.
APA
Nakayama, T., Saito, R., Furuya, S., Shoda, K., Maruyma, S., Takiguchi, K. ... Ichikawa, D. (2023). Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer. Oncology Letters, 26, 538. https://doi.org/10.3892/ol.2023.14125
MLA
Nakayama, T., Saito, R., Furuya, S., Shoda, K., Maruyma, S., Takiguchi, K., Shiraishi, K., Akaike, H., Kawaguchi, Y., Amemiya, H., Kawaida, H., Tsukiji, N., Shirai, T., Shinmori, H., Yamamoto, M., Nomura, S., Tsukamoto, T., Suzuki‑Inoue, K., Ichikawa, D."Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer". Oncology Letters 26.6 (2023): 538.
Chicago
Nakayama, T., Saito, R., Furuya, S., Shoda, K., Maruyma, S., Takiguchi, K., Shiraishi, K., Akaike, H., Kawaguchi, Y., Amemiya, H., Kawaida, H., Tsukiji, N., Shirai, T., Shinmori, H., Yamamoto, M., Nomura, S., Tsukamoto, T., Suzuki‑Inoue, K., Ichikawa, D."Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer". Oncology Letters 26, no. 6 (2023): 538. https://doi.org/10.3892/ol.2023.14125
Copy and paste a formatted citation
x
Spandidos Publications style
Nakayama T, Saito R, Furuya S, Shoda K, Maruyma S, Takiguchi K, Shiraishi K, Akaike H, Kawaguchi Y, Amemiya H, Amemiya H, et al: Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer. Oncol Lett 26: 538, 2023.
APA
Nakayama, T., Saito, R., Furuya, S., Shoda, K., Maruyma, S., Takiguchi, K. ... Ichikawa, D. (2023). Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer. Oncology Letters, 26, 538. https://doi.org/10.3892/ol.2023.14125
MLA
Nakayama, T., Saito, R., Furuya, S., Shoda, K., Maruyma, S., Takiguchi, K., Shiraishi, K., Akaike, H., Kawaguchi, Y., Amemiya, H., Kawaida, H., Tsukiji, N., Shirai, T., Shinmori, H., Yamamoto, M., Nomura, S., Tsukamoto, T., Suzuki‑Inoue, K., Ichikawa, D."Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer". Oncology Letters 26.6 (2023): 538.
Chicago
Nakayama, T., Saito, R., Furuya, S., Shoda, K., Maruyma, S., Takiguchi, K., Shiraishi, K., Akaike, H., Kawaguchi, Y., Amemiya, H., Kawaida, H., Tsukiji, N., Shirai, T., Shinmori, H., Yamamoto, M., Nomura, S., Tsukamoto, T., Suzuki‑Inoue, K., Ichikawa, D."Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer". Oncology Letters 26, no. 6 (2023): 538. https://doi.org/10.3892/ol.2023.14125
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