Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2024 Volume 27 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2024 Volume 27 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.xlsx
    • Supplementary_Data2.pdf
Article Open Access

miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia

  • Authors:
    • Eleni Tsotridou
    • Elisavet Georgiou
    • Athanasios Tragiannidis
    • Chrysostomos Avgeros
    • Georgios Tzimagiorgis
    • Maria Lambrou
    • Eugenia Papakonstantinou
    • Assimina Galli‑Tsinopoulou
    • Emmanouel Hatzipantelis
  • View Affiliations / Copyright

    Affiliations: Children and Adolescent Hematology‑Oncology Unit, 2nd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki AHEPA University Hospital, Thessaloniki 546 36, Greece, Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece, Department of Pediatric Hematology and Oncology, Hippokration General Hospital, Thessaloniki 546 42, Greece
    Copyright: © Tsotridou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 71
    |
    Published online on: December 21, 2023
       https://doi.org/10.3892/ol.2023.14204
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNAs (miRNAs/miRs) are promising prognostic biomarkers in pediatric acute lymphoblastic leukemia (ALL). The present study aimed to identify miRNAs that could serve as prognostic biomarkers or as novel therapeutic targets in ALL. The expression levels of 84 miRNAs were assessed in the bone marrow aspirates of 10 pediatric patients with newly diagnosed ALL at diagnosis and on day 33 of induction of the ALL Intercontinental Berlin‑Frankfurt‑Münster 2009 protocol, and associations with established prognostic factors were evaluated. The levels at diagnosis of 25 miRNAs were associated with ≥2 prognostic factors. Higher expression levels of let‑7c‑5p, miR‑106b‑5p, miR‑26a‑5p, miR‑155‑5p, miR‑191‑5p, miR‑30b‑5p and miR‑31‑5p were significantly associated with a good prednisone response. The expression levels of miR‑125b‑5p, miR‑150‑5p and miR‑99a‑5p were significantly higher in standard‑ or intermediate‑risk patients compared with those in high‑risk patients (P=0.017, P=0.033 and P=0.017, respectively), as well as in those with a complete response at the end of induction (P=0.044 for all three miRNAs). The change in expression levels between diagnosis and the end of induction differed significantly between risk groups for three miRNAs: miR‑206, miR‑210 and miR‑99a (P=0.033, P=0.047 and P=0.008, respectively), with the post induction levels of miR‑206 increased in high‑risk patients, whilst miR‑210 and miR‑99a levels were increased in intermediate/standard risk patients. Therefore, miRNAs that could be integrated into the risk stratification of pediatric ALL after further evaluation in larger patient cohorts were identified.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Howlader N, Noone AM, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ and Cronin KA: SEER Cancer Statistics Review, 1975–2018. National Cancer Institute; Bethesda, MD: 2011

2 

Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, Reaman GH and Carroll WL: Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the children's oncology group. J Clin Oncol. 30:1663–1669. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Pui CH, Carroll WL, Meshinchi S and Arceci RJ: Biology, risk stratification, and therapy of pediatric acute leukemias: An update. J Clin Oncol. 29:551–565. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Eckert C, Parker C, Moorman AV, Irving JA, Kirschner-Schwabe R, Groeneveld-Krentz S, Révész T, Hoogerbrugge P, Hancock J, Sutton R, et al: Risk factors and outcomes in children with high-risk B-cell precursor and T-cell relapsed acute lymphoblastic leukaemia: Combined analysis of ALLR3 and ALL-REZ BFM 2002 clinical trials. Eur J Cancer. 151:175–189. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Pui CH, Mullighan CG, Evans WE and Relling MV: Pediatric acute lymphoblastic leukemia: Where are we going and how do we get there? Blood. 120:1165–1174. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Woo JS, Alberti MO and Tirado CA: Childhood B-acute lymphoblastic leukemia: A genetic update. Exp Hematol Oncol. 3:162014. View Article : Google Scholar : PubMed/NCBI

7 

Esquela-Kerscher A and Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Montagner S, Dehó L and Monticelli S: MicroRNAs in hematopoietic development. BMC Immunol. 15:142014. View Article : Google Scholar : PubMed/NCBI

9 

Carvalho de Oliveira J, Molinari Roberto G, Baroni M, Bezerra Salomão K, Alejandra Pezuk J and Sol Brassesco M: MiRNA dysregulation in childhood hematological cancer. Int J Mol Sci. 19:26882018. View Article : Google Scholar : PubMed/NCBI

10 

Gutierrez-Camino A, Garcia-Obregon S, Lopez-Lopez E, Astigarraga I and Garcia-Orad A: MiRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review. Epigenomics. 12:69–80. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Szczepanek J: Role of microRNA dysregulation in childhood acute leukemias: Diagnostics, monitoring and therapeutics: A comprehensive review. World J Clin Oncol. 11:348–369. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Durmaz B, Bagca BG, Cogulu O, Susluer SY, Alpay A, Aksoylar S and Gunduz C: Antileukemic Effects of Anti-miR-146a, Anti-miR-155, Anti-miR-181a, and prednisolone on childhood acute lymphoblastic leukemia. Biomed Res Int. 2021:32073282021. View Article : Google Scholar : PubMed/NCBI

13 

Stary J, Zimmermann M, Campbell M, Castillo L, Dibar E, Donska S, Gonzalez A, Izraeli S, Janic D, Jazbec J, et al: Intensive chemotherapy for childhood acute lymphoblastic leukemia: Results of the randomized intercontinental trial ALL IC-BFM 2002. J Clin Oncol. 32:174–184. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Licursi V, Conte F, Fiscon G and Paci P: MIENTURNET: An interactive web tool for microRNA-target enrichment and network-based analysis. BMC Bioinformatics. 20:5452019. View Article : Google Scholar : PubMed/NCBI

16 

Hsu SD, Lin FM, Wu WY, Liang C, Huang WC, Chan WL, Tsai WT, Chen GZ, Lee CJ, Chiu CM, et al: miRTarBase: A database curates experimentally validated microRNA-target interactions. Nucleic Acids Res. 39:(Database issue). D163–D169. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Gillespie M, Jassal B, Stephan R, Milacic M, Rothfels K, Senff-Ribeiro A, Griss J, Sevilla C, Matthews L, Gong C, et al: The reactome pathway knowledgebase 2022. Nucleic Acids Res. 50((D1)): D687–D692. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Riehm H, Reiter A, Schrappe M, Berthold F, Dopfer R, Gerein V, Ludwig R, Ritter J, Stollmann B and Henze G: Corticosteroid-dependent reduction of leukocyte count in blood as a prognostic factor in acute lymphoblastic leukemia in childhood (therapy study ALL-BFM 83). Klin Padiatr. 199:151–160. 1987.(In German). View Article : Google Scholar : PubMed/NCBI

19 

Dördelmann M, Reiter A, Borkhardt A, Ludwig WD, Götz N, Viehmann S, Gadner H, Riehm H and Schrappe M: Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia. Blood. 94:1209–1217. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Schrappe M, Möricke A, Reiter A, Henze G, Welte K, Gadner H, Ludwig WD, Ritter J, Harbott J, Mann G, et al: Key treatment questions in childhood acute lymphoblastic leukemia: results in 5 consecutive trials performed by the ALL-BFM study group from 1981 to 2000. Klin Padiatr. 225 (Suppl):S62–S72. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Lauten M, Möricke A, Beier R, Zimmermann M, Stanulla M, Meissner B, Odenwald E, Attarbaschi A, Niemeyer C, Niggli F, et al: Prediction of outcome by early bone marrow response in childhood acute lymphoblastic leukemia treated in the ALL-BFM 95 trial: Differential effects in precursor B-cell and T-cell leukemia. Haematologica. 97:1048–1056. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Aye Y, Li M, Long MJ and Weiss RS: Ribonucleotide reductase and cancer: Biological mechanisms and targeted therapies. Oncogene. 34:2011–2021. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Su YF, Wu TF, Ko JL, Tsai HT, Tee YT, Chien MH, Chou CH, Lin WL, Low HY, Chou MY, et al: The expression of ribonucleotide reductase M2 in the carcinogenesis of uterine cervix and its relationship with clinicopathological characteristics and prognosis of cancer patients. PLoS One. 9:e916442014. View Article : Google Scholar : PubMed/NCBI

24 

Thomas AL, Coarfa C, Qian J, Wilkerson JJ, Rajapakshe K, Krett NL, Gunaratne PH and Rosen ST: Identification of potential glucocorticoid receptor therapeutic targets in multiple myeloma. Nucl Recept Signal. 13:e0062015. View Article : Google Scholar : PubMed/NCBI

25 

Zuo Z, Zhou Z, Chang Y, Liu Y, Shen Y, Li Q and Zhang L: Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer. Genes Dis. 11:218–233. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Han BW, Feng DD, Li ZG, Luo XQ, Zhang H, Li XJ, Zhang XJ, Zheng LL, Zeng CW, Lin KY, et al: A set of miRNAs that involve in the pathways of drug resistance and leukemic stem-cell differentiation is associated with the risk of relapse and glucocorticoid response in childhood ALL. Hum Mol Genet. 20:4903–4915. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Yuan B, Zhang J, Wang H, Xiong L, Cai Q, Wang T, Jacobsen S, Pradhan S and Wang Y: 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1. Cancer Res. 71:1904–1911. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Selvakumar P, Lakshmikuttyamma A, Dimmock JR and Sharma RK: Methionine aminopeptidase 2 and cancer. Biochim Biophys Acta. 1765:148–154. 2006.PubMed/NCBI

29 

Volk A, Liang K, Suraneni P, Li X, Zhao J, Bulic M, Marshall S, Pulakanti K, Malinge S, Taub J, et al: A CHAF1B-Dependent molecular switch in hematopoiesis and leukemia pathogenesis. Cancer Cell. 34:707–723.e7. 2018. View Article : Google Scholar : PubMed/NCBI

30 

El-Khazragy N, Elshimy AA, Hassan SS, Matbouly S, Safwat G, Zannoun M and Riad RA: Dysregulation of miR-125b predicts poor response to therapy in pediatric acute lymphoblastic leukemia. J Cell Biochem. 120:7428–7438. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Piatopoulou D, Avgeris M, Marmarinos A, Xagorari M, Baka M, Doganis D, Kossiva L, Scorilas A and Gourgiotis D: MiR-125b predicts childhood acute lymphoblastic leukaemia poor response to BFM chemotherapy treatment. Br J Cancer. 117:801–812. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Schotte D, Chau JCK, Sylvester G, Liu G, Chen C, van der Velden VH, Broekhuis MJ, Peters TC, Pieters R and den Boer ML: Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia. Leukemia. 23:313–322. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Chaudhuri AA, So AY, Mehta A, Minisandram A, Sinha N, Jonsson VD, Rao DS, O'Connell RM and Baltimore D: Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. Proc Natl Acad Sci USA. 109:4233–4238. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Willimott S and Wagner SD: miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells. J Biol Chem. 287:2608–2617. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Li XJ, Luo XQ, Han BW, Duan FT, Wei PP and Chen YQ: MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways. Br J Cancer. 109:2189–2198. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Zhang L, Li X, Ke Z, Huang L, Liang Y, Wu J, Zhang X, Chen Y, Zhang H and Luo X: MiR-99a may serve as a potential oncogene in pediatric myeloid leukemia. Cancer Cell Int. 13:1102013. View Article : Google Scholar : PubMed/NCBI

37 

Schotte D, De Menezes RX, Akbari Moqadam F, Khankahdani LM, Lange-Turenhout E, Chen C, Pieters R and Den Boer ML: MicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia. Haematologica. 96:703–711. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Akbari Moqadam F, Lange-Turenhout EA, Ariës IM, Pieters R and den Boer ML: MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia. Leuk Res. 37:1315–1321. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Zhang H, Luo XQ, Zhang P, Huang LB, Zheng YS, Wu J, Zhou H, Qu LH, Xu L and Chen YQ: MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS One. 4:e78262009. View Article : Google Scholar : PubMed/NCBI

40 

Avigad S, Verly IR, Lebel A, Kordi O, Shichrur K, Ohali A, Hameiri-Grossman M, Kaspers GJ, Cloos J, Fronkova E, et al: miR expression profiling at diagnosis predicts relapse in pediatric precursor B-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer. 55:328–339. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Fang ZH, Wang SL, Zhao JT, Lin ZJ, Chen LY, Su R, Xie ST, Carter BZ and Xu B: miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways. Cell Death Dis. 7:e23712016. View Article : Google Scholar : PubMed/NCBI

42 

Naderi T, Mohammadi-Yeganeh S, Mohammadi-Hezaveh N, Hadavi R, Gharehbaghian A, Vazifeh-Shiran N, Fallah Azad V and Paryan M: Investigating the inhibitory effect of miR-34a, miR-449a, miR-1827, and miR-106b on target genes including NOTCH1, c-Myc, and CCND1 in human T cell acute lymphoblastic leukemia clinical samples and cell line. Iran J Basic Med Sci. 23:376–382. 2020.PubMed/NCBI

43 

Verboon LJ, Obulkasim A, De Rooij JD, Katsman-Kuipers JE, Sonneveld E, Baruchel A, Trka J, Reinhardt D, Pieters R, Cloos J, et al: MicroRNA-106b ~ 25 cluster is upregulated in relapsed MLL-rearranged pediatric acute myeloid leukemia. Oncotarget. 7:48412–48422. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Xu L, Liang YN, Luo XQ, Liu XD and Guo HX: Association of miRNAs expression profiles with prognosis and relapse in childhood acute lymphoblastic leukemia. Zhonghua Xue Ye Xue Za Zhi. 32:178–181. 2011.(In Chinese). PubMed/NCBI

45 

Jiang L, Qian J, Yang Y and Fan Y: Knockdown of MON1B exerts anti-tumor effects in colon cancer in vitro. Med Sci Monit. 24:7710–7718. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Kordes U, Krappmann D, Heissmeyer V, Ludwig WD and Scheidereit C: Transcription factor NF-κB is constitutively activated in acute lymphoblastic leukemia cells. Leukemia. 14:399–402. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Ueno H, Yoshida K, Shiozawa Y, Nannya Y, Iijima-Yamashita Y, Kiyokawa N, Shiraishi Y, Chiba K, Tanaka H, Isobe T, et al: Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia. Blood Adv. 4:5165–5173. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Oh L, Hainaut P, Blanchet S and Ariffin H: Expression of p53 N-terminal isoforms in B-cell precursor acute lymphoblastic leukemia and its correlation with clinicopathological profiles. BMC Cancer. 20:1102020. View Article : Google Scholar : PubMed/NCBI

49 

Nakagawa S, Kawahara K, Okamoto Y, Kodama Y, Nishikawa T, Kawano Y and Furukawa T: Association between dysfunction of the nucleolar stress response and multidrug resistance in pediatric acute lymphoblastic leukemia. Cancers (Basel). 14:51272022. View Article : Google Scholar : PubMed/NCBI

50 

Devlin C, Greco S, Martelli F and Ivan M: miR-210: More than a silent player in hypoxia. IUBMB Life. 63:94–100. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Chan SY and Loscalzo J: MicroRNA-210: A unique and pleiotropic hypoxamir. Cell Cycle. 9:1072–1083. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Mei Y, Gao C, Wang K, Cui L, Li W, Zhao X, Liu F, Wu M, Deng G, Ding W, et al: Effect of microRNA-210 on prognosis and response to chemotherapeutic drugs in pediatric acute lymphoblastic leukemia. Cancer Sci. 105:463–472. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Mei Y, Li Z, Zhang Y, Zhang W, Hu H, Zhang P, Wu M and Huang D: Low miR-210 and CASP8AP2 expression is associated with a poor outcome in pediatric acute lymphoblastic leukemia. Oncol Lett. 14:8072–8077. 2017.PubMed/NCBI

54 

Khalilian S, Hosseini Imani SZ and Ghafouri-Fard S: Emerging roles and mechanisms of miR-206 in human disorders: A comprehensive review. Cancer Cell Int. 22:4122022. View Article : Google Scholar : PubMed/NCBI

55 

Sun H, Zhang Z, Luo W, Liu J, Lou Y and Xia S: NET1 enhances proliferation and chemoresistance in acute lymphoblastic leukemia cells. Oncol Res. 27:935–944. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Contreras Yametti GP, Ostrow TH, Jasinski S, Raetz EA, Carroll WL and Evensen NA: Minimal residual disease in acute lymphoblastic leukemia: Current practice and future directions. Cancers (Basel). 13:18472021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tsotridou E, Georgiou E, Tragiannidis A, Avgeros C, Tzimagiorgis G, Lambrou M, Papakonstantinou E, Galli‑Tsinopoulou A and Hatzipantelis E: miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia. Oncol Lett 27: 71, 2024.
APA
Tsotridou, E., Georgiou, E., Tragiannidis, A., Avgeros, C., Tzimagiorgis, G., Lambrou, M. ... Hatzipantelis, E. (2024). miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia. Oncology Letters, 27, 71. https://doi.org/10.3892/ol.2023.14204
MLA
Tsotridou, E., Georgiou, E., Tragiannidis, A., Avgeros, C., Tzimagiorgis, G., Lambrou, M., Papakonstantinou, E., Galli‑Tsinopoulou, A., Hatzipantelis, E."miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia". Oncology Letters 27.2 (2024): 71.
Chicago
Tsotridou, E., Georgiou, E., Tragiannidis, A., Avgeros, C., Tzimagiorgis, G., Lambrou, M., Papakonstantinou, E., Galli‑Tsinopoulou, A., Hatzipantelis, E."miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia". Oncology Letters 27, no. 2 (2024): 71. https://doi.org/10.3892/ol.2023.14204
Copy and paste a formatted citation
x
Spandidos Publications style
Tsotridou E, Georgiou E, Tragiannidis A, Avgeros C, Tzimagiorgis G, Lambrou M, Papakonstantinou E, Galli‑Tsinopoulou A and Hatzipantelis E: miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia. Oncol Lett 27: 71, 2024.
APA
Tsotridou, E., Georgiou, E., Tragiannidis, A., Avgeros, C., Tzimagiorgis, G., Lambrou, M. ... Hatzipantelis, E. (2024). miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia. Oncology Letters, 27, 71. https://doi.org/10.3892/ol.2023.14204
MLA
Tsotridou, E., Georgiou, E., Tragiannidis, A., Avgeros, C., Tzimagiorgis, G., Lambrou, M., Papakonstantinou, E., Galli‑Tsinopoulou, A., Hatzipantelis, E."miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia". Oncology Letters 27.2 (2024): 71.
Chicago
Tsotridou, E., Georgiou, E., Tragiannidis, A., Avgeros, C., Tzimagiorgis, G., Lambrou, M., Papakonstantinou, E., Galli‑Tsinopoulou, A., Hatzipantelis, E."miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia". Oncology Letters 27, no. 2 (2024): 71. https://doi.org/10.3892/ol.2023.14204
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team