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Association and predictive value of contrast‑enhanced ultrasound features with axillary lymph node metastasis in primary breast cancer

  • Authors:
    • Xiufeng Kuang
    • Lichun Lin
    • Huafang Yuan
    • Linfang Zhao
    • Ting He
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasonography, First People's Hospital of Linping District, Hangzhou, Zhejiang 311100, P.R. China, Department of Special Inspection, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310005, P.R. China, Department of Ultrasonography, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Kuang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 98
    |
    Published online on: January 12, 2024
       https://doi.org/10.3892/ol.2024.14231
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Abstract

Primary breast cancer is the most common malignant tumor in women worldwide, and axillary lymph node metastasis (ALNM) is an important marker of disease progression in patients with breast cancer. The objective of the present study was to analyze the association between contrast‑enhanced ultrasound (CEUS) features and ALNM in primary breast cancer and its predictive value. A total of 120 patients with breast cancer were assigned to the non‑metastatic group (n=70) and metastatic group (n=50). The factors influencing ALNM were explored by multivariate logistic regression analysis. The consistency of CEUS, ordinary ultrasonography and pathological examination in the diagnosis of the ALNM of breast cancer was evaluated by consistency testing. The sensitivity, specificity and consistency rate of CEUS features and ordinary ultrasonography were analyzed by receiver operating characteristic curve and four‑fold table analyses. High enhancement amplitude, centripetal enhancement sequence, increased maximum cortical thickness, high peak intensity and a larger area under the curve of lymph nodes were more commonly found in the metastatic group than in the non‑metastatic group. The lymph node aspect ratio and time to peak were lower in the metastatic group than the non‑metastatic group. The time to peak was a protective factor for ALNM in patients with breast cancer. The sensitivity, specificity and coincidence rate with pathological examination of CEUS in the diagnosis of ALNM were 92.00, 90.00 and 90.83%, while these of ordinary ultrasonography were 76.00, 80.00 and 78.33%, respectively. The consistency test indicated that CEUS and pathological examination were consistent in the diagnosis of ALNM in patients with breast cancer, with a κ value of 0.816, indicating a good consistency. The κ value of ordinary ultrasonography and pathological examination was 0.763, also indicating a good consistency. However, these results indicate that CEUS is more valuable than ordinary ultrasonography in the diagnosis of ALNM in cases of breast cancer. In conclusion, the present study indicates that CEUS features were influencing factors associated with ALNM in patients with breast cancer and may serve as an important reference for the preoperative prediction of ALNM in breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Kuang X, Lin L, Yuan H, Zhao L and He T: Association and predictive value of contrast‑enhanced ultrasound features with axillary lymph node metastasis in primary breast cancer. Oncol Lett 27: 98, 2024.
APA
Kuang, X., Lin, L., Yuan, H., Zhao, L., & He, T. (2024). Association and predictive value of contrast‑enhanced ultrasound features with axillary lymph node metastasis in primary breast cancer. Oncology Letters, 27, 98. https://doi.org/10.3892/ol.2024.14231
MLA
Kuang, X., Lin, L., Yuan, H., Zhao, L., He, T."Association and predictive value of contrast‑enhanced ultrasound features with axillary lymph node metastasis in primary breast cancer". Oncology Letters 27.3 (2024): 98.
Chicago
Kuang, X., Lin, L., Yuan, H., Zhao, L., He, T."Association and predictive value of contrast‑enhanced ultrasound features with axillary lymph node metastasis in primary breast cancer". Oncology Letters 27, no. 3 (2024): 98. https://doi.org/10.3892/ol.2024.14231
Copy and paste a formatted citation
x
Spandidos Publications style
Kuang X, Lin L, Yuan H, Zhao L and He T: Association and predictive value of contrast‑enhanced ultrasound features with axillary lymph node metastasis in primary breast cancer. Oncol Lett 27: 98, 2024.
APA
Kuang, X., Lin, L., Yuan, H., Zhao, L., & He, T. (2024). Association and predictive value of contrast‑enhanced ultrasound features with axillary lymph node metastasis in primary breast cancer. Oncology Letters, 27, 98. https://doi.org/10.3892/ol.2024.14231
MLA
Kuang, X., Lin, L., Yuan, H., Zhao, L., He, T."Association and predictive value of contrast‑enhanced ultrasound features with axillary lymph node metastasis in primary breast cancer". Oncology Letters 27.3 (2024): 98.
Chicago
Kuang, X., Lin, L., Yuan, H., Zhao, L., He, T."Association and predictive value of contrast‑enhanced ultrasound features with axillary lymph node metastasis in primary breast cancer". Oncology Letters 27, no. 3 (2024): 98. https://doi.org/10.3892/ol.2024.14231
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