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Preoperative visceral fat index predicts the survival outcomes of patients with gastric cancer after surgery

  • Authors:
    • Lugen Zuo
    • Jianxiu Lin
    • Sitang Ge
    • Rong Wu
    • Baoxinzi Liu
    • Ying Cheng
    • Yun Tian
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of General Surgery, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210000, P.R. China, Department of Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine and Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Zuo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 99
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    Published online on: January 15, 2024
       https://doi.org/10.3892/ol.2024.14233
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Abstract

Visceral adipose tissue and skeletal muscle mass are associated with carcinogenesis and clinical outcomes in patients with cancer. The aim of the present study was to determine the influence of body composition parameters on postoperative survival in patients with gastric cancer. Demographic data and systemic inflammatory response data were obtained from patients with gastric cancer undergoing radical gastrectomy. The patient's skeletal muscle and visceral fat were assessed using computed tomography, and the corresponding skeletal muscle index (SMI) and visceral fat index (VFI) were calculated. Univariate and multivariate analyses were then performed. Of the 342 patients from whom information was collected, 125 of these patients eventually succumbed to the disease. A total of 271 (79.24%) of the patients were male and 71 (20.76%) were female. Regarding the entire cohort, the mean age was 64 years [interquartile range (IQR), 56‑74 years], while the mean body mass index collected was 21.53 (IQR, 19.27‑24.22). The median SMI and VFI of the patients were 47.73 (IQR, 41.67‑55.51) and 41.28 (IQR, 36.62‑45.36), respectively. It was concluded that a low SMI and VFI were associated with worse survival outcomes. However, the neutrophil‑to‑lymphocyte ratio and perioperative blood transfusion were not significantly associated with overall survival (OS). Among the indicators assessed, a low VFI was an independent risk factor associated with the worst OS time (hazard ratio 1.59; confidence interval, 1.03‑2.45; P=0.038). Finally, a prognostic nomogram was constructed which included the VFI to assist clinicians in making more informed decisions. In conclusion, after data collection and analysis, it was found that there was a significant correlation between a low VFI and a shorter OS time in patients with gastric cancer following gastrectomy, suggesting that VFI may be a promising therapeutic target for postoperative interventions to improve patient survival further.
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Copy and paste a formatted citation
Spandidos Publications style
Zuo L, Lin J, Ge S, Wu R, Liu B, Cheng Y and Tian Y: Preoperative visceral fat index predicts the survival outcomes of patients with gastric cancer after surgery. Oncol Lett 27: 99, 2024.
APA
Zuo, L., Lin, J., Ge, S., Wu, R., Liu, B., Cheng, Y., & Tian, Y. (2024). Preoperative visceral fat index predicts the survival outcomes of patients with gastric cancer after surgery. Oncology Letters, 27, 99. https://doi.org/10.3892/ol.2024.14233
MLA
Zuo, L., Lin, J., Ge, S., Wu, R., Liu, B., Cheng, Y., Tian, Y."Preoperative visceral fat index predicts the survival outcomes of patients with gastric cancer after surgery". Oncology Letters 27.3 (2024): 99.
Chicago
Zuo, L., Lin, J., Ge, S., Wu, R., Liu, B., Cheng, Y., Tian, Y."Preoperative visceral fat index predicts the survival outcomes of patients with gastric cancer after surgery". Oncology Letters 27, no. 3 (2024): 99. https://doi.org/10.3892/ol.2024.14233
Copy and paste a formatted citation
x
Spandidos Publications style
Zuo L, Lin J, Ge S, Wu R, Liu B, Cheng Y and Tian Y: Preoperative visceral fat index predicts the survival outcomes of patients with gastric cancer after surgery. Oncol Lett 27: 99, 2024.
APA
Zuo, L., Lin, J., Ge, S., Wu, R., Liu, B., Cheng, Y., & Tian, Y. (2024). Preoperative visceral fat index predicts the survival outcomes of patients with gastric cancer after surgery. Oncology Letters, 27, 99. https://doi.org/10.3892/ol.2024.14233
MLA
Zuo, L., Lin, J., Ge, S., Wu, R., Liu, B., Cheng, Y., Tian, Y."Preoperative visceral fat index predicts the survival outcomes of patients with gastric cancer after surgery". Oncology Letters 27.3 (2024): 99.
Chicago
Zuo, L., Lin, J., Ge, S., Wu, R., Liu, B., Cheng, Y., Tian, Y."Preoperative visceral fat index predicts the survival outcomes of patients with gastric cancer after surgery". Oncology Letters 27, no. 3 (2024): 99. https://doi.org/10.3892/ol.2024.14233
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