Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2024 Volume 27 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2024 Volume 27 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Myelodysplastic syndrome with IgG4‑related disease: A case report

  • Authors:
    • Lina Wang
    • Xi Pang
    • Zirui Hong
    • Baodong Ye
    • Zhiping Hu
    • Chunli Zhang
    • Shuyan Liu
  • View Affiliations / Copyright

    Affiliations: The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Emergency Department, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China, Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang 310006, P.R. China, Department of Pathology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 166
    |
    Published online on: February 20, 2024
       https://doi.org/10.3892/ol.2024.14299
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

At present, to the best of our knowledge, there are only a few case reports of IgG4‑related disease (IgG4‑RD) involving myelodysplastic syndrome (MDS), yet the incidence of MDS and IgG4‑RD is increasing in middle‑aged and elderly people. The present study presents a case of MDS combined with IgG4‑RD admitted to Zhejiang Provincial Hospital of Chinese Medicine in September 2022. The (66‑year‑old; male) patient was admitted to the hospital due to hematopenia with an elevated IgG4 index. The diagnosis of MDS combined with IgG4‑RD was confirmed after various exams, including pathological examination. The condition of the patient improved after 3 weeks of hormone therapy, with a significant increase in complete blood count compared with the pre‑treatment period. MDS is a malignant hematological disorder with a high risk of conversion to leukemia, and IgG4‑RD is a systemic immune‑mediated disease with a poor prognosis often associated with malignancy. The present study presents and reviews the literature to better understand the coexistence of these two diseases.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Tanaka TN and Bejar R: MDS overlap disorders and diagnostic boundaries. Blood. 133:1086–1095. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Frumm SM, Shimony S, Stone RM, DeAngelo DJ, Bewersdorf JP, Zeidan AM and Stahl M: Why do we not have more drugs approved for MDS? A critical viewpoint on novel drug development in MDS. Blood Rev. 60:1010562023. View Article : Google Scholar : PubMed/NCBI

3 

Garcia-Manero G: Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management. Am J Hematol. 98:1307–1325. 2023. View Article : Google Scholar : PubMed/NCBI

4 

Lanzillotta M, Mancuso G and Della-Torre E: Advances in the diagnosis and management of IgG4 related disease. BMJ. 369:m10672020. View Article : Google Scholar : PubMed/NCBI

5 

Wick MR and O'Malley DP: Lymphadenopathy associated with IgG4-related disease: Diagnosis & differential diagnosis. Semin Diagn Pathol. 35:61–66. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Katz G and Stone JH: Clinical perspectives on IgG4-related disease and its classification. Annu Rev Med. 73:545–562. 2022. View Article : Google Scholar : PubMed/NCBI

7 

Wallace ZS, Wallace CJ, Lu N, Choi HK and Stone JH: Association of IgG4-related disease with history of malignancy. Arthritis Rheumatol. 68:2283–2289. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Ferry JA, Klepeis V, Sohani AR, Harris NL, Preffer FI, Stone JH, Grove A and Deshpande V: IgG4-related orbital disease and its mimics in a western population. Am J Surg Pathol. 39:1688–1700. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Chen LYC, Mattman A, Seidman MA and Carruthers MN: IgG4-related disease: What a hematologist needs to know. Haematologica. 104:444–455. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M and Vardiman JW: The 2016 revision to the world health organization classification of myeloid neoplasms and acute leukemia. Blood. 127:2391–2405. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Patnaik MM and Tefferi A: Refractory anemia with ring sideroblasts (RARS) and RARS with thrombocytosis: ‘2019 update on diagnosis, risk-stratification, and management’. Am J Hematol. 94:475–488. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Estey E, Hasserjian RP and Döhner H: Distinguishing AML from MDS: A fixed blast percentage may no longer be optimal. Blood. 139:323–332. 2022. View Article : Google Scholar : PubMed/NCBI

13 

Scalzulli E, Pepe S, Colafigli G and Breccia M: Therapeutic strategies in low and high-risk MDS: What does the future have to offer? Blood Rev. 45:1006892021. View Article : Google Scholar : PubMed/NCBI

14 

Danlos FX, Rossi GM, Blockmans D, Emmi G, Kronbichler A, Durupt S, Maynard C, Luca L, Garrouste C, Lioger B, et al: Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: A new overlap syndrome. Autoimmun Rev. 16:1036–1043. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Nowak V, Agaimy A, Kristiansen G and Gütgemann I: Increased IgG4-positive plasma cells in nodular-sclerosing Hodgkin lymphoma: A diagnostic pitfall. Histopathology. 76:244–250. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Chen LYC, Slack GW and Carruthers MN: IgG4-related disease and Rosai-Dorfman-Destombes disease. Lancet. 398:1213–1214. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Baenas DF, Miretti VS, Caeiro F and Paira S: Differential diagnosis between pancreatic involvement in IgG4-related disease and pancreatic cancer. Gastroenterol Hepatol. 44:144–155. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Yu T, Wu Y, Liu J, Zhuang Y, Jin X and Wang L: The risk of malignancy in patients with IgG4-related disease: A systematic review and meta-analysis. Arthritis Res Ther. 24:142022. View Article : Google Scholar : PubMed/NCBI

19 

Wallace ZS, Naden RP, Chari S, Choi HK, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, et al: The 2019 American college of rheumatology/european league against rheumatism classification criteria for IgG4-related disease. Ann Rheum Dis. 79:77–87. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Martín-Nares E, Hernández-Molina G, Baenas DF and Paira S: IgG4-related disease: Mimickers and diagnostic pitfalls. J Clin Rheumatol. 28:e596–e604. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Furukawa S, Moriyama M, Miyake K, Nakashima H, Tanaka A, Maehara T, Iizuka-Koga M, Tsuboi H, Hayashida JN, Ishiguro N, et al: Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease. Sci Rep. 7:424132017. View Article : Google Scholar : PubMed/NCBI

22 

Hong J, Kim S and Lin PC: Interleukin-33 and ST2 signaling in tumor microenvironment. J Interferon Cytokine Res. 39:61–71. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Cush JJ and Dao KH: Malignancy risks with biologic therapies. Rheum Dis Clin North Am. 38:761–770. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Dzhus M, Ivashkivsky O, Mikukst V, Parkishen S and Diadyk O: IgG4-related disease misdiagnosed as neoplasm. J Clin Rheumatol. 27:e71–e72. 2021. View Article : Google Scholar : PubMed/NCBI

25 

Martínez-de-Alegría A, Baleato-González S, García-Figueiras R, Bermúdez-Naveira A, Abdulkader-Nallib I, Díaz-Peromingo JA and Villalba-Martín C: IgG4-related disease from head to toe. Radiographics. 35:2007–2025. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Bertoglio P, Viti A, Paiano S, Assante LR, Bogina GS, Pomari C, Zamboni G and Terzi AC: IgG4-related disease: A new challenging diagnosis mimicking lung cancer. Interact Cardiovasc Thorac Surg. 28:410–412. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Tsuda B, Kumaki N, Ishida R, Mizuno M, Yokoyama K, Oshitanai R, Terao M, Morioka T, Okamura T, Saito Y, et al: Distinction of IgG4-related mastitis from breast cancer: A case report. Surg Case Rep. 5:1232019. View Article : Google Scholar : PubMed/NCBI

28 

Notohara K, Kamisawa T, Uchida K, Zen Y, Kawano M, Kasashima S, Sato Y, Shiokawa M, Uehara T, Yoshifuji H, et al: Gastrointestinal manifestation of immunoglobulin G4-related disease: Clarification through a multicenter survey. J Gastroenterol. 53:845–853. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Mizuno R, Yamanishi Y, Uda S, Terashima T, Higashi T and Higuchi T: Invasive cervical cancer accompanied by IgG4-related disease. J Obstet Gynaecol Res. 42:1198–1202. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Liu Z, Zhang S, Zhang W, Feng J, Li M and Zeng X: Immunoglobulin G4-related disease accompanied by primary myelofibrosis: Case report. Front Med (Lausanne). 8:6387942021. View Article : Google Scholar : PubMed/NCBI

31 

Okamoto A, Watanabe T, Kamata K, Minaga K and Kudo M: Recent updates on the relationship between cancer and autoimmune pancreatitis. Intern Med. 58:1533–1539. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Barcellini W, Giannotta JA and Fattizzo B: Autoimmune complications in hematologic neoplasms. Cancers (Basel). 13:15322021. View Article : Google Scholar : PubMed/NCBI

33 

Xiao N, He X, Niu H, Yu H, Cui N, Li H, Yan L, Shao Z, Xing L and Wang H: Increased circulating CD4(+)CXCR5(+) cells and IgG4 levels in patients with myelodysplastic syndrome with autoimmune diseases. J Immunol Res. 2021:43025152021. View Article : Google Scholar : PubMed/NCBI

34 

Asano J, Watanabe T, Oguchi T, Kanai K, Maruyama M, Ito T, Muraki T, Hamano H, Arakura N, Matsumoto A and Kawa S: Association between immunoglobulin G4-related disease and malignancy within 12 years after diagnosis: An analysis after longterm followup. J Rheumatol. 42:2135–2142. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Roupie AL, Guedon A, Terrier B, Lahuna C, Jachiet V, Regent A, de Boysson H, Carrat F, Seguier J, Terriou L, et al: Vasculitis associated with myelodysplastic syndrome and chronic myelomonocytic leukemia: French multicenter case-control study. Semin Arthritis Rheum. 50:879–884. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Gonzalez CA, Carrillo Linares JL, García Muñoz I, Escalona García A and Valdivielso P: IgG4-Related disease affecting testicle and myelodysplastic syndrome: Just a coincidence? Eur J Case Rep Intern Med. 8:0029812021.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang L, Pang X, Hong Z, Ye B, Hu Z, Zhang C and Liu S: Myelodysplastic syndrome with IgG4‑related disease: A case report. Oncol Lett 27: 166, 2024.
APA
Wang, L., Pang, X., Hong, Z., Ye, B., Hu, Z., Zhang, C., & Liu, S. (2024). Myelodysplastic syndrome with IgG4‑related disease: A case report. Oncology Letters, 27, 166. https://doi.org/10.3892/ol.2024.14299
MLA
Wang, L., Pang, X., Hong, Z., Ye, B., Hu, Z., Zhang, C., Liu, S."Myelodysplastic syndrome with IgG4‑related disease: A case report". Oncology Letters 27.4 (2024): 166.
Chicago
Wang, L., Pang, X., Hong, Z., Ye, B., Hu, Z., Zhang, C., Liu, S."Myelodysplastic syndrome with IgG4‑related disease: A case report". Oncology Letters 27, no. 4 (2024): 166. https://doi.org/10.3892/ol.2024.14299
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Pang X, Hong Z, Ye B, Hu Z, Zhang C and Liu S: Myelodysplastic syndrome with IgG4‑related disease: A case report. Oncol Lett 27: 166, 2024.
APA
Wang, L., Pang, X., Hong, Z., Ye, B., Hu, Z., Zhang, C., & Liu, S. (2024). Myelodysplastic syndrome with IgG4‑related disease: A case report. Oncology Letters, 27, 166. https://doi.org/10.3892/ol.2024.14299
MLA
Wang, L., Pang, X., Hong, Z., Ye, B., Hu, Z., Zhang, C., Liu, S."Myelodysplastic syndrome with IgG4‑related disease: A case report". Oncology Letters 27.4 (2024): 166.
Chicago
Wang, L., Pang, X., Hong, Z., Ye, B., Hu, Z., Zhang, C., Liu, S."Myelodysplastic syndrome with IgG4‑related disease: A case report". Oncology Letters 27, no. 4 (2024): 166. https://doi.org/10.3892/ol.2024.14299
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team