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Case Report Open Access

Spontaneous rupture‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations

  • Authors:
    • Xiaosong Li
    • Shenghan Xu
    • Yunbin Li
    • Yanping Tang
    • Kaiying Wang
    • Yumeng Lei
    • Jian Ma
    • Jian Li
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Urology, The People's Hospital of Liupanshui, Liupanshui, Guizhou 553001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 183
    |
    Published online on: February 28, 2024
       https://doi.org/10.3892/ol.2024.14316
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Abstract

Spontaneous rupture and hemorrhage of mediastinal germ cell tumors is a rare occurrence. In the current report, the case of a 20‑year‑old male patient who was admitted with chest tightness and dyspnea is presented. An urgent chest CT scan revealed a large tumor in the right anterior mediastinum, measuring ~12 cm in diameter, with associated intratumoral hemorrhage. An emergency thoracotomy was performed to excise the lesion, which revealed that the bleeding was caused by a ruptured tumor. Postoperative pathological findings revealed a mediastinal mixed germ cell tumor consisting of four pathological types: Embryonal carcinoma, seminoma, yolk sac tumor and immature teratoma. Postoperatively, the patient showed marked improvement in the symptoms of dyspnea. However, the follow‑up outcome was poor, and the patient succumbed 2 months after surgery. To the best of our knowledge, there are no reports of rupture and hemorrhage involving >4 mixed germ cell tumors. In the present report, the experience of the treatment of the patient is summarized, and literature was reviewed to improve clinicians' awareness of the disease.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Xu S, Li Y, Tang Y, Wang K, Lei Y, Ma J and Li J: Spontaneous rupture‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations. Oncol Lett 27: 183, 2024.
APA
Li, X., Xu, S., Li, Y., Tang, Y., Wang, K., Lei, Y. ... Li, J. (2024). Spontaneous rupture‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations. Oncology Letters, 27, 183. https://doi.org/10.3892/ol.2024.14316
MLA
Li, X., Xu, S., Li, Y., Tang, Y., Wang, K., Lei, Y., Ma, J., Li, J."Spontaneous rupture‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations". Oncology Letters 27.4 (2024): 183.
Chicago
Li, X., Xu, S., Li, Y., Tang, Y., Wang, K., Lei, Y., Ma, J., Li, J."Spontaneous rupture‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations". Oncology Letters 27, no. 4 (2024): 183. https://doi.org/10.3892/ol.2024.14316
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Xu S, Li Y, Tang Y, Wang K, Lei Y, Ma J and Li J: Spontaneous rupture‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations. Oncol Lett 27: 183, 2024.
APA
Li, X., Xu, S., Li, Y., Tang, Y., Wang, K., Lei, Y. ... Li, J. (2024). Spontaneous rupture‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations. Oncology Letters, 27, 183. https://doi.org/10.3892/ol.2024.14316
MLA
Li, X., Xu, S., Li, Y., Tang, Y., Wang, K., Lei, Y., Ma, J., Li, J."Spontaneous rupture‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations". Oncology Letters 27.4 (2024): 183.
Chicago
Li, X., Xu, S., Li, Y., Tang, Y., Wang, K., Lei, Y., Ma, J., Li, J."Spontaneous rupture‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations". Oncology Letters 27, no. 4 (2024): 183. https://doi.org/10.3892/ol.2024.14316
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