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PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors

  • Authors:
    • Chengcheng You
    • Jinlan He
    • Chunyu Cao
    • Deqiao Sheng
    • Lin Wang
    • Zhixian Huang
    • Xiaoling Zhang
    • Changjun Yi
    • Yingming Sun
    • Yiling Huang
  • View Affiliations / Copyright

    Affiliations: Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, Hubei 443002, P.R. China, Department of Obstetrics, Yiling People's Hospital of Yichang City, The First Affiliated Hospital of Hubei Three Gorges Polytechnic, Yichang, Hubei 443002, P.R. China, Department of Histopathology, Yichang Akeman Pathology and Diagnostics Center, Yichang, Hubei 443002, P.R. China, Department of Medical and Radiation Oncology, Affiliated Sanming First Hospital of Fujian Medical University, Sanming, Fujian 365001, P.R. China
    Copyright: © You et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 216
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    Published online on: March 19, 2024
       https://doi.org/10.3892/ol.2024.14349
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Abstract

Although recombinant human TNF‑related apoptosis‑inducing ligand (TRAIL) protein exhibits antitumor activity in a number of lung and liver cancer cells and tumor‑bearing animals, TRAIL resistance has substantially restricted its clinical application. Pyrroline‑5‑carboxylate reductase 1 (PYCR1) is a key enzyme in the regulation of proline synthesis. PYCR1 is highly expressed in various types of malignant tumor, in which it has been implicated in 5‑fluorouracil resistance. However, the possible relationship between PYCR1 and TRAIL resistance remains unclear. In the present study, both reverse transcription‑quantitative PCR and western blotting were performed. The results indicated that H1299 cells had higher PYCR1 expression levels and were less sensitive to TRAIL compared with the TRAIL‑sensitive cell line, H460. PYCR1 knockdown in H1299 cells increased TRAIL sensitivity, increased the localization of death receptors (DRs) on the cell surface and activated Caspase‑3/8. By contrast, overexpression of PYCR1 in H1299 cells decreased TRAIL sensitivity, reduced the distribution of DRs on the cell surface and suppressed the activation of Caspase‑3/8. Taken together, these results suggested that PYCR1 promoted TRAIL resistance in the non‑small cell lung cancer cell line, H1299, by preventing redistribution of DRs to the plasma membrane. This in turn inhibited TRAIL‑mediated cell apoptosis by reducing the activation of Caspase‑3/8.
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1 

Cao W, Chen HD, Yu YW, Li N and Chen WQ: Changing profiles of cancer burden worldwide and in China: A secondary analysis of the global cancer statistics 2020. Chin Med J (Engl). 134:783–791. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Wang Z, Wu X, Chen HN and Wang K: Amino acid metabolic reprogramming in tumor metastatic colonization. Front Oncol. 13:11231922023. View Article : Google Scholar : PubMed/NCBI

4 

Krishnan N, Dickman MB and Becker DF: Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress. Free Radic Biol Med. 44:671–681. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Pandhare J, Donald SP, Cooper SK and Phang JM: Regulation and function of proline oxidase under nutrient stress. J Cell Biochem. 107:759–768. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Bogner AN, Stiers KM and Tanner JJ: Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target. Amino Acids. 53:1817–1834. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Hu CA, Williams DB, Zhaorigetu S, Khalil S, Wan G and Valle D: Functional genomics and SNP analysis of human genes encoding proline metabolic enzymes. Amino Acids. 35:655–664. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Phang JM, Liu W and Zabirnyk O: Proline metabolism and microenvironmental stress. Annu Rev Nutr. 30:441–463. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Meng Z, Lou Z, Liu Z, Li M, Zhao X, Bartlam M and Rao Z: Crystal structure of human pyrroline-5-carboxylate reductase. J Mol Biol. 359:1364–1377. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Christensen EM, Patel SM, Korasick DA, Campbell AC, Krause KL, Becker DF and Tanner JJ: Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. J Biol Chem. 292:7233–7243. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Dimopoulou A, Fischer B, Gardeitchik T, Schroter P, Kayserili H, Schlack C, Li Y, Brum JM, Barisic I, Castori M, et al: Genotype-phenotype spectrum of PYCR1-related autosomal recessive cutis laxa. Mol Genet Metab. 110:352–361. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Scherrer DZ, Baptista MB, Matos AH, Maurer-Morelli CV and Steiner CE: Mutations in PYCR1 gene in three families with autosomal recessive cutis laxa, type 2. Eur J Med Genet. 56:336–339. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Yasuda T, Kaji Y, Agatsuma T, Niki T, Arisawa M, Shuto S, Ariga H and Iguchi-Ariga SM: DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. Biochem Biophys Res Commun. 436:289–294. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Ding J, Kuo ML, Su L, Xue L, Luh F, Zhang H, Wang J, Lin TG, Zhang K, Chu P, et al: Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers. Carcinogenesis. 38:519–531. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C and Smith CA: Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 3:673–682. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Hao C, Song JH, Hsi B, Lewis J, Song DK, Petruk KC, Tyrrell DL and Kneteman NM: TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice. Cancer Res. 64:8502–8506. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Jong K, Mohamed E and Ibrahim ZA: Escaping cell death via TRAIL decoy receptors: A systematic review of their roles and expressions in colorectal cancer. Apoptosis. 27:787–799. 2022. View Article : Google Scholar : PubMed/NCBI

18 

She Y, Mao A, Li F and Wei X: P5CR1 protein expression and the effect of gene-silencing on lung adenocarcinoma. Peer J. 7:e69342019. View Article : Google Scholar : PubMed/NCBI

19 

Yan K, Xu X, Wu T, Li J, Cao G, Li Y and Ji Z: Knockdown of PYCR1 inhibits proliferation, drug resistance and EMT in colorectal cancer cells by regulating STAT3-Mediated p38 MAPK and NF-kappaB signalling pathway. Biochem Biophys Res Commun. 520:486–491. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Mert U and Sanlioglu AD: Intracellular localization of DR5 and related regulatory pathways as a mechanism of resistance to TRAIL in cancer. Cell Mol Life Sci. 74:245–255. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Ouyang W, Yang C, Liu Y, Xiong J, Zhang J, Zhong Y, Zhang G, Zhou F, Zhou Y and Xie C: Redistribution of DR4 and DR5 in lipid rafts accounts for the sensitivity to TRAIL in NSCLC cells. Int J Oncol. 39:1577–1586. 2011.PubMed/NCBI

23 

You C, Sun Y, Zhang S, Tang G, Zhang N, Li C, Tian X, Ma S, Luo Y, Sun W, et al: Trichosanthin enhances sensitivity of non-small cell lung cancer (NSCLC) TRAIL-resistance cells. Int J Biol Sci. 14:217–227. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Cao C, D'Amico T, Demmy T, Dunning J, Gossot D, Hansen H, He J, Jheon S, Petersen RH, Sihoe A, et al: Surgery versus SABR for resectable non-small-cell lung cancer. Lancet Oncol. 16:e370–e371. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Kischkel FC, Lawrence DA, Chuntharapai A, Schow P, Kim KJ and Ashkenazi A: Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity. 12:611–620. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Ashkenazi A: Directing cancer cells to self-destruct with pro-apoptotic receptor agonists. Nat Rev Drug Discov. 7:1001–1012. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Johnstone RW, Frew AJ and Smyth MJ: The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer. 8:782–798. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Maksimovic-Ivanic D, Stosic-Grujicic S, Nicoletti F and Mijatovic S: Resistance to TRAIL and how to surmount it. Immunol Res. 52:157–168. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Fan S, Li Y, Yue P, Khuri FR and Sun SY: The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation. Neoplasia. 12:346–356. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Cai F, Miao Y, Liu C, Wu T, Shen S, Su X and Shi Y: Pyrroline-5-carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non-small cell lung cancer. Oncol Lett. 15:731–740. 2018.PubMed/NCBI

32 

Xue W, Wu K, Guo X, Chen C, Huang T, Li L, Liu B, Chang H and Zhao J: The pan-cancer landscape of glutamate and glutamine metabolism: A comprehensive bioinformatic analysis across 32 solid cancer types. Biochim Biophys Acta Mol Basis Dis. 1870:1669822024. View Article : Google Scholar : PubMed/NCBI

33 

Oudaert I, Satilmis H, Vlummens P, De Brouwer W, Maes A, Hose D, De Bruyne E, Ghesquiere B, Vanderkerken K, De Veirman K and Menu E: Pyrroline-5-carboxylate reductase 1: A novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis. J Exp Clin Cancer Res. 41:452022. View Article : Google Scholar : PubMed/NCBI

34 

Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A and Mootha VK: Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat Commun. 5:31282014. View Article : Google Scholar : PubMed/NCBI

35 

Schwörer S, Berisa M, Violante S, Qin W, Zhu J, Hendrickson RC, Cross JR and Thompson CB: Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress. EMBO J. 39:e1033342020. View Article : Google Scholar : PubMed/NCBI

36 

Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW and Phang JM: Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc Natl Acad Sci USA. 109:8983–8988. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
You C, He J, Cao C, Sheng D, Wang L, Huang Z, Zhang X, Yi C, Sun Y, Huang Y, Huang Y, et al: PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors. Oncol Lett 27: 216, 2024.
APA
You, C., He, J., Cao, C., Sheng, D., Wang, L., Huang, Z. ... Huang, Y. (2024). PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors. Oncology Letters, 27, 216. https://doi.org/10.3892/ol.2024.14349
MLA
You, C., He, J., Cao, C., Sheng, D., Wang, L., Huang, Z., Zhang, X., Yi, C., Sun, Y., Huang, Y."PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors". Oncology Letters 27.5 (2024): 216.
Chicago
You, C., He, J., Cao, C., Sheng, D., Wang, L., Huang, Z., Zhang, X., Yi, C., Sun, Y., Huang, Y."PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors". Oncology Letters 27, no. 5 (2024): 216. https://doi.org/10.3892/ol.2024.14349
Copy and paste a formatted citation
x
Spandidos Publications style
You C, He J, Cao C, Sheng D, Wang L, Huang Z, Zhang X, Yi C, Sun Y, Huang Y, Huang Y, et al: PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors. Oncol Lett 27: 216, 2024.
APA
You, C., He, J., Cao, C., Sheng, D., Wang, L., Huang, Z. ... Huang, Y. (2024). PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors. Oncology Letters, 27, 216. https://doi.org/10.3892/ol.2024.14349
MLA
You, C., He, J., Cao, C., Sheng, D., Wang, L., Huang, Z., Zhang, X., Yi, C., Sun, Y., Huang, Y."PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors". Oncology Letters 27.5 (2024): 216.
Chicago
You, C., He, J., Cao, C., Sheng, D., Wang, L., Huang, Z., Zhang, X., Yi, C., Sun, Y., Huang, Y."PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors". Oncology Letters 27, no. 5 (2024): 216. https://doi.org/10.3892/ol.2024.14349
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