Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2024 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2024 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma

  • Authors:
    • Shufang Xie
    • Lifen Zhu
    • Lei Wang
    • Shibing Wang
    • Xiangmin Tong
    • Wanmao Ni
  • View Affiliations / Copyright

    Affiliations: The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, P.R. China, Cancer Center, Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China, Cancer Center, Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 237
    |
    Published online on: March 28, 2024
       https://doi.org/10.3892/ol.2024.14370
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The objective of the present study was to assess the levels of circulating cytokines in patients with diffuse large B‑cell lymphoma (DLBCL), and to examine the associations between the cytokine levels, clinicopathological manifestations and patient prognosis. The study enrolled 49 patients with DLBCL, 11 patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and 67 healthy controls from Zhejiang Provincial People's Hospital (Hangzhou, China) between January 2017 and January 2020. The serum levels of interleukin (IL)‑2, IL‑4, IL‑6, IL‑10, IL‑17, tumor necrosis factor (TNF)‑α and interferon (IFN)‑γ were measured using flow cytometry. The IL‑6, IL‑10 and IFN‑γ levels were significantly raised in patients with DLBCL compared with those in the healthy controls (P<0.05). The levels of IL‑10 were significantly higher in patients with raised levels of circulating lactate dehydrogenase (P<0.05), while increases in both IL‑6 and IL‑10 were associated with raised C‑reactive protein (CRP) levels, with IL‑6 levels positively associated with those of serum CRP (P<0.01; r=0.66). Additionally, International Prognostic Index (IPI) risk stratification of patients with DLBCL was strongly associated with circulating IL‑6 and IL‑10 levels. Raised IL‑6, IL‑10 and TNF‑α levels were linked with worse short‑term treatment efficacies (P<0.05). Moreover, the accuracy of the model predicting short‑term treatment response in patients with DLBCL, obtained using the support vector machine algorithm, was 81.63%. It was also found that raised serum IL‑6 and IL‑10 levels, together with reduced levels of IL‑17, were associated with survival of <1 year in patients with DLBCL (P<0.05), although no significant link was found between cytokine levels and long‑term overall survival. In conclusion, the serum levels of IL‑6, IL‑10, IL‑17, TNF‑α and IFN‑γ can potentially serve as biological indicators of DLBCL tumor immune status, and combined application with the IPI score can be a robust prognostic indicator in patients with DLBCL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Tout M, Casasnovas O, Meignan M, Lamy T, Morschhauser F, Salles G, Gyan E, Haioun C, Mercier M, Feugier P, et al: Rituximab exposure is influenced by baseline metabolic tumor volume and predicts outcome of DLBCL patients: A lymphoma study association report. Blood. 129:2616–2623. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Tárnok A, Hambsch J, Chen R and Varro R: Cytometric bead array to measure six cytokines in twenty-five microliters of serum. Clin Chem. 49:1000–1002. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Malaponte G, Hafsi S, Polesel J, Castellano G, Spessotto P, Guarneri C, Canevari S, Signorelli SS, McCubrey JA and Libra M: Tumor microenvironment in diffuse large B-cell lymphoma: Matrixmetalloproteinases activation is mediated by osteopontin overexpression. Biochim Biophys Acta. 1863:483–489. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Lim SH, Woo SY, Kim S, Ko YH, Kim WS and Kim SJ: Cross-sectional Study of Patients with Diffuse Large B-Cell Lymphoma: Assessing the effect of host status, tumor burden, and inflammatory activity on venous thromboembolism. Cancer Res Treat. 48:312–321. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Falduto A, Cimino F, Speciale A, Musolino C, Gangemi S, Saija A and Allegra A: How gene polymorphisms can influence clinical response and toxicity following R-CHOP therapy in patients with diffuse large B cell lymphoma. Blood Rev. 31:235–249. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Zhou Z, Sehn LH, Rademaker AW, Gordon LI, Lacasce AS, Crosby-Thompson A, Vanderplas A, Zelenetz AD, Abel GA, Rodriguez MA, et al: An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era. Blood. 123:837–842. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Dlouhy I, Filella X, Rovira J, Magnano L, Rivas-Delgado A, Baumann T, Martínez-Trillos A, Balagué O, Martínez A, González-Farre B, et al: High serum levels of soluble interleukin-2 receptor (sIL2-R), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF) are associated with adverse clinical features and predict poor outcome in diffuse large B-cell lymphoma. Leuk Res. 59:20–25. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Zhong W, Xu X, Zhu Z, Du Q, Du H, Yang L, Ling Y, Xiong H and Li Q: Increased expression of IRF8 in tumor cells inhibits the generation of Th17 cells and predicts unfavorable survival of diffuse large B cell lymphoma patients. Oncotarget. 8:49757–49772. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Hashwah H, Bertram K, Stirm K, Stelling A, Wu CT, Kasser S, Manz MG, Theocharides AP, Tzankov A and Müller A: The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma. EMBO Mol Med. 11:e105762019. View Article : Google Scholar : PubMed/NCBI

10 

Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian and Leukaemia Lymphoma Group; Eastern Cooperative Oncology Group, ; et al: Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. J Clin Oncol. 32:3059–3068. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Ruppert AS, Dixon JG, Salles G, Wall A, Cunningham D, Poeschel V, Haioun C, Tilly H, Ghesquieres H, Ziepert M, et al: International prognostic indices in diffuse large B-cell lymphoma: A comparison of IPI, R-IPI, and NCCN-IPI. Blood. 135:2041–2048. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Zelenetz AD, Gordon LI, Abramson JS, Advani RH, Bartlett NL, Caimi PF, Chang JE, Chavez JC, Christian B, Fayad LE, et al: NCCN Guidelines Insights: B-Cell Lymphomas, Version 3.2019. J Natl Compr Canc Netw. 17:650–661. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Zhao S, Dong X, Shen W, Ye Z and Xiang R: Machine learning-based classification of diffuse large B-cell lymphoma patients by eight gene expression profiles. Cancer Med. 5:837–852. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Chen H, Zhang J, Sun X, Wang Y and Qian Y: Mitophagy-mediated molecular subtypes depict the hallmarks of the tumour metabolism and guide precision chemotherapy in pancreatic adenocarcinoma. Front Cell Dev Biol. 10:9012072022. View Article : Google Scholar : PubMed/NCBI

15 

Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A, Pfreundschuh M and Pileri SA: Diffuse large B-cell lymphoma. Crit Rev Oncol Hematol. 87:146–171. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Nagai H, Miyaki D, Matsui T, Kanayama M, Higami K, Momiyama K, Ikehara T, Watanabe M, Sumino Y and Miki K: Th1/Th2 balance: An important indicator of efficacy for intra-arterial chemotherapy. Cancer Chemother Pharmacol. 62:959–963. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Peng X, Shi J, Sun W, Ruan X, Guo Y, Zhao L, Wang J and Li B: Genetic polymorphisms of IL-6 promoter in cancer susceptibility and prognosis: A meta-analysis. Oncotarget. 9:12351–12364. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Narazaki M, Tanaka T and Kishimoto T: The role and therapeutic targeting of IL-6 in rheumatoid arthritis. Expert Rev Clin Immunol. 13:535–551. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Xiu B, Lin Y, Grote DM, Ziesmer SC, Gustafson MP, Maas ML, Zhang Z, Dietz AB, Porrata LF, Novak AJ, et al: IL-10 induces the development of immunosuppressive CD14(+)HLA-DR(low/-) monocytes in B-cell non-Hodgkin lymphoma. Blood Cancer J. 5:e3282015. View Article : Google Scholar : PubMed/NCBI

20 

Purdue MP, Lan Q, Kricker A, Grulich AE, Vajdic CM, Turner J, Whitby D, Chanock S, Rothman N and Armstrong BK: Polymorphisms in immune function genes and risk of non-Hodgkin lymphoma: Findings from the New South Wales non-Hodgkin Lymphoma Study. Carcinogenesis. 28:704–712. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Park YH, Sohn SK, Kim JG, Lee MH, Song HS, Kim MK, Jung JS, Lee JJ, Kim HJ and Kim DH: Interaction between BCL2 and interleukin-10 gene polymorphisms alter outcomes of diffuse large B-cell lymphoma following rituximab plus CHOP chemotherapy. Clin Cancer Res. 15:2107–2115. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Nakamura N, Goto N, Tsurumi H, Takemura M, Kanemura N, Kasahara S, Hara T, Yasuda I, Shimizu M, Sawada M, et al: Serum level of soluble tumor necrosis factor receptor 2 is associated with the outcome of patients with diffuse large B-cell lymphoma treated with the R-CHOP regimen. Eur J Haematol. 91:322–331. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Nakayama S, Yokote T, Hirata Y, Akioka T, Miyoshi T, Hiraoka N, Iwaki K, Takayama A, Nishiwaki U, Masuda Y, et al: TNF-α expression in tumor cells as a novel prognostic marker for diffuse large B-cell lymphoma, not otherwise specified. Am J Surg Pathol. 38:228–234. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Cruceriu D, Baldasici O, Balacescu O and Berindan-Neagoe I: The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: Molecular insights and therapeutic approaches. Cell Oncol (Dordr). 43:1–8. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Qu Y, Wang X, Bai S, Niu L, Zhao G, Yao Y, Li B and Li H: The effects of TNF-α/TNFR2 in regulatory T cells on the microenvironment and progression of gastric cancer. Int J Cancer. 150:1373–1391. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Camicia R, Bachmann SB, Winkler HC, Beer M, Tinguely M, Haralambieva E and Hassa PO: BAL1/ARTD9 represses the anti-proliferative and pro-apoptotic IFNү-STAT1-IRF1-p53 axis in diffuse large B-cell lymphoma. J Cell Sci. 126((Pt 9)): 1969–1980. 2013.PubMed/NCBI

27 

Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM and Stockinger B: TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 24:179–189. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Fayad L, Keating MJ, Reuben JM, O'Brien S, Lee BN, Lerner S and Kurzrock R: Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: Correlation with phenotypic characteristics and outcome. Blood. 97:256–263. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Nacinovic-Duletic A, Stifter S, Dvornik S, Skunca Z and Jonjic N: Correlation of serum IL-6, IL-8 and IL-10 levels with clinicopathological features and prognosis in patients with diffuse large B-cell lymphoma. Int J Lab Hematol. 30:230–239. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Aydin F, Yilmaz M, Ozdemir F, Kavgaci H, Yavuz MN and Yavuz AA: Correlation of serum IL-2, IL-6 and IL-10 levels with International Prognostic Index in patients with aggressive non-Hodgkin's lymphoma. Am J Clin Oncol. 25:570–572. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Guney N, Soydinc HO, Basaran M, Bavbek S, Derin D, Camlica H, Yasasever V and Topuz E: Serum levels of interleukin-6 and interleukin-10 in Turkish patients with aggressive non-Hodgkin's lymphoma. Asian Pac J Cancer Prev. 10:669–674. 2009.PubMed/NCBI

32 

Niitsu N, Okamato M, Nakamine H, Yoshino T, Tamaru J, Nakamura S, Higashihara M and Hirano M: Simultaneous elevation of the serum concentrations of vascular endothelial growth factor and interleukin-6 as independent predictors of prognosis in aggressive non-Hodgkin's lymphoma. Eur J Haematol. 68:912002. View Article : Google Scholar : PubMed/NCBI

33 

Cortes J and Kurzrock R: Interleukin-10 in non-Hodgkin's lymphoma. Leuk Lymphoma. 26:251–259. 1997. View Article : Google Scholar : PubMed/NCBI

34 

D'Mello KP, Zhao L, Kaser EC, Zhu Z, Xiao H, Wakefield MR, Bai Q and Fang Y: The role of interleukins and the widely studied TNF-α in non-Hodgkin's lymphoma. Med Oncol. 38:562021. View Article : Google Scholar : PubMed/NCBI

35 

Uskudar Teke H, Gunduz E, Akay OM, Bal C and Gulbas Z: Are the high serum interleukin-6 and vascular endothelial growth factor levels useful prognostic markers in aggressive non-hodgkin lymphoma patients? Turk J Haematol. 32:21–28. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xie S, Zhu L, Wang L, Wang S, Tong X and Ni W: Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma. Oncol Lett 27: 237, 2024.
APA
Xie, S., Zhu, L., Wang, L., Wang, S., Tong, X., & Ni, W. (2024). Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma. Oncology Letters, 27, 237. https://doi.org/10.3892/ol.2024.14370
MLA
Xie, S., Zhu, L., Wang, L., Wang, S., Tong, X., Ni, W."Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma". Oncology Letters 27.5 (2024): 237.
Chicago
Xie, S., Zhu, L., Wang, L., Wang, S., Tong, X., Ni, W."Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma". Oncology Letters 27, no. 5 (2024): 237. https://doi.org/10.3892/ol.2024.14370
Copy and paste a formatted citation
x
Spandidos Publications style
Xie S, Zhu L, Wang L, Wang S, Tong X and Ni W: Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma. Oncol Lett 27: 237, 2024.
APA
Xie, S., Zhu, L., Wang, L., Wang, S., Tong, X., & Ni, W. (2024). Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma. Oncology Letters, 27, 237. https://doi.org/10.3892/ol.2024.14370
MLA
Xie, S., Zhu, L., Wang, L., Wang, S., Tong, X., Ni, W."Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma". Oncology Letters 27.5 (2024): 237.
Chicago
Xie, S., Zhu, L., Wang, L., Wang, S., Tong, X., Ni, W."Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma". Oncology Letters 27, no. 5 (2024): 237. https://doi.org/10.3892/ol.2024.14370
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team