Prognostic significance of connective tissue growth factor expression in stromal cells in patients with diffuse‑type gastric cancer

Miki,Yuichiro; Yoshii,Mami; Miyauchi,Ryoko; Kasashima,Hiroaki; Fukuoka,Tatsunari; Tamura,Tatsuro; Shibutani,Masatsune; Toyokawa,Takahiro; Lee,Shigeru; Yashiro,Masakazu; Maeda,Kiyoshi

doi:10.3892/ol.2024.14374

June-2024 Volume 27 Issue 6

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June-2024 Volume 27 Issue 6

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Prognostic significance of connective tissue growth factor expression in stromal cells in patients with diffuse‑type gastric cancer

Authors:
- Yuichiro Miki
- Mami Yoshii
- Ryoko Miyauchi
- Hiroaki Kasashima
- Tatsunari Fukuoka
- Tatsuro Tamura
- Masatsune Shibutani
- Takahiro Toyokawa
- Shigeru Lee
- Masakazu Yashiro
- Kiyoshi Maeda
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Affiliations: Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka 545‑8585, Japan

Copyright: © Miki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 241
|
Published online on: April 3, 2024

https://doi.org/10.3892/ol.2024.14374
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Abstract

Connective tissue growth factor (CTGF) is a target gene of the Hippo signaling pathway. Its differential role in the histological types of gastric cancer (GC) remains unknown; therefore, the present study aimed to confirm the clinical significance of CTGF expression in cancer and stromal cells in patients with GC depending on the histological type. The present study enrolled 589 patients with GC. Immunohistochemistry was used to analyze CTGF expression in cancer and stromal cells. CTGF mRNA expression data and the corresponding clinical information of GC samples were collected from The Cancer Genome Atlas (TCGA) database. Subsequently, the associations between CTGF expression and several clinicopathological factors were investigated. In the present study, CTGF expression was mainly observed in the cytoplasm of cancer and stromal cells. CTGF expression in stromal cells was significantly associated with CTGF expression in cancer cells (P<0.001). CTGF positivity in stromal cells was also significantly associated with intestinal type, non‑scirrhous type, tumor depth (T1‑2), lymph node metastasis (negative), lymphatic invasion (negative) and tumor size (<5 cm). Low CTGF expression in stromal cells was independently associated with worse overall survival (OS). Furthermore, the OS of patients with low CTGF expression in stromal cells, especially in patients with diffuse‑type GC, was significantly worse than patients with high CTGF expression (P=0.022). This trend was similar to that revealed by TCGA data analysis. In conclusion, low CTGF expression was associated with a significantly worse OS in patients with diffuse‑type GC. These data indicated that CTGF, and its control by the Hippo pathway, may be considered potential treatment targets in diffuse‑type GC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prognostic significance of connective tissue growth factor expression in stromal cells in patients with diffuse‑type gastric cancer

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