Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer

  • Authors:
    • Ercan Pulat
    • Mehmet R. Topçul
  • View Affiliations

  • Published online on: April 3, 2024     https://doi.org/10.3892/ol.2024.14376
  • Article Number: 243
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In the present study, antiproliferative and anticancer effects of Valamor (VLM), which contains the active component ribociclib, and DPQ, a poly(ADP‑ribose) polymerase 1 inhibitor, alone and in combination were evaluated in the MCF‑7 and MDA‑MB‑231 breast cancer cell lines in vitro. VLM was applied at concentrations of 40, 80 and 160 µg/ml, and DPQ was used at concentrations of 3, 6 and 9 µg/ml. The proliferation rate, cell index obtained from the real‑time cell analysis system, mitosis activity, bromodeoxyuridine cell proliferation and caspase activity parameters were determined. In conclusion, the results obtained from cell kinetics parameters demonstrated the anticancer and antiproliferative effects of the combination of VLM and DPQ on breast cancer cells.

Related Articles

Journal Cover

June-2024
Volume 27 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Pulat E and Pulat E: Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer. Oncol Lett 27: 243, 2024
APA
Pulat, E., & Pulat, E. (2024). Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer. Oncology Letters, 27, 243. https://doi.org/10.3892/ol.2024.14376
MLA
Pulat, E., Topçul, M. R."Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer". Oncology Letters 27.6 (2024): 243.
Chicago
Pulat, E., Topçul, M. R."Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer". Oncology Letters 27, no. 6 (2024): 243. https://doi.org/10.3892/ol.2024.14376