Open Access

Oncolytic virotherapy stimulates anti‑tumor immune response and demonstrates activity in advanced sarcoma: Report of two cases

  • Authors:
    • Yeting Qiu
    • Aijun Qin
    • Ronghua Zhao
    • Jun Ding
    • William Wei‑Guo Jia
    • Manu Singh
    • Yanal Murad
    • Qian Tan
    • Ganessan Kichenadasse
  • View Affiliations

  • Published online on: April 3, 2024     https://doi.org/10.3892/ol.2024.14377
  • Article Number: 244
  • Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sarcoma is derived from mesenchymal neoplasms and has numerous subtypes, accounting for 1% of all adult malignancies and 15% of childhood malignancies. The prognosis of metastatic or recurrent sarcoma remains poor. The current study presents two cases of sarcoma enrolled in a phase I dose escalation trial for solid tumor, who had previously failed all standard therapies. These patients were treated with VG161, an immune‑stimulating herpes simplex virus type 1 oncolytic virus with payloads of IL‑12, IL‑15 and IL‑15 receptor α unit, and a programmed cell death 1 (PD‑1)/PD‑1 ligand 1 blocking peptide. Both cases demonstrated stable disease as the best response, accompanied by a noteworthy prolongation of progression‑free survival (11.8 months for chondrosarcoma and 11.9 months for soft tissue sarcoma, respectively) at a dose of 2.5x108 PFU/cycle. In addition, the treatment led to the activation of anti‑cancer immunity, as evident from cytokine, lymphocyte subset and related pathway analyses of peripheral blood and/or tumor biopsy samples. These promising results suggest that VG161 monotherapy holds promise as an effective treatment for sarcoma and warrants further investigation through clinical trials. The two reported patients were part of a phase I clinical trial conducted and registered on the Australian New Zealand Clinical Trials Registry in Australia (registration no. ACTRN12620000244909; registration date, 26 February, 2020).
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June-2024
Volume 27 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Qiu Y, Qin A, Ding J, Jia WW, Singh M, Murad Y, Tan Q, Kichenadasse G and Zhao R: Oncolytic virotherapy stimulates anti‑tumor immune response and demonstrates activity in advanced sarcoma: Report of two cases. Oncol Lett 27: 244, 2024
APA
Qiu, Y., Qin, A., Ding, J., Jia, W.W., Singh, M., Murad, Y. ... Zhao, R. (2024). Oncolytic virotherapy stimulates anti‑tumor immune response and demonstrates activity in advanced sarcoma: Report of two cases. Oncology Letters, 27, 244. https://doi.org/10.3892/ol.2024.14377
MLA
Qiu, Y., Qin, A., Ding, J., Jia, W. W., Singh, M., Murad, Y., Tan, Q., Kichenadasse, G., Zhao, R."Oncolytic virotherapy stimulates anti‑tumor immune response and demonstrates activity in advanced sarcoma: Report of two cases". Oncology Letters 27.6 (2024): 244.
Chicago
Qiu, Y., Qin, A., Ding, J., Jia, W. W., Singh, M., Murad, Y., Tan, Q., Kichenadasse, G., Zhao, R."Oncolytic virotherapy stimulates anti‑tumor immune response and demonstrates activity in advanced sarcoma: Report of two cases". Oncology Letters 27, no. 6 (2024): 244. https://doi.org/10.3892/ol.2024.14377