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Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study

  • Authors:
    • Kazuki Kobayashi
    • Takahiro Einama
    • Takazumi Tsunenari
    • Naoto Yonamine
    • Mikiya Takao
    • Yasuhiro Takihata
    • Hironori Tsujimoto
    • Hideki Ueno
    • Katsumi Tamura
    • Jiro Ishida
    • Yoji Kishi
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan, Department of Radiology, Tokorozawa PET Diagnostic Imaging Clinic, Tokorozawa, Saitama 359‑1124, Japan
    Copyright: © Kobayashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 279
    |
    Published online on: April 23, 2024
       https://doi.org/10.3892/ol.2024.14412
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Abstract

Tumor resectability, which is increasingly determined based on preoperative chemotherapy, is critical in determining the best treatment for pancreatic cancers. The present study evaluated the usefulness of serum carbohydrate antigen 19‑9 (CA19‑9) and the preoperative 8F‑fluorodeoxyglucose positron emission tomography/computed tomography standardized uptake value (SUV) percentage change (SUVmax%=[(SUVmax2‑SUVmax1)/SUVmax1] x100, where SUVmax1 and SUVmax2 represent the initial and delayed phases, respectively) as biological factors indicative of tumor resectability. The present study included patients with resectable pancreatic cancer who underwent complete surgical resection, for whom both CA19‑9 and SUVmax% were documented using cut‑off values of 500 U/ml and 24.25%, respectively. Patients were classified as follows: i) High CA19‑9 and SUVmax%: both CA19‑9 and SUVmax% were elevated; ii) high CA19‑9 or SUVmax%: either CA19‑9 or SUVmax% were elevated; or iii) low CA19‑9 and SUVmax%: neither value met the cut‑off. Relapse‑free survival (RFS) and overall survival (OS) were calculated, for which univariate and multivariate analyses were performed. Of the 86 patients included, 39 were classified as high CA19‑9 or SUVmax% and 12 as high CA19‑9 and SUVmax%, with the former group having a significantly worse RFS (vs. low CA19‑9 and SUVmax%; P<0.001; vs. high CA19‑9 or SUVmax%; P=0.011) and OS (vs. low CA19‑9 and SUVmax%, P=0.002; vs. high CA19‑9 or SUVmax%, P<0.001). Therefore, high CA19‑9 and SUVmax% was an independent predictor of worse RFS (P<0.001) and OS (P=0.003). In conclusion, CA19‑9 and SUVmax% can be utilized as biological indicators of resectability.
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Copy and paste a formatted citation
Spandidos Publications style
Kobayashi K, Einama T, Tsunenari T, Yonamine N, Takao M, Takihata Y, Tsujimoto H, Ueno H, Tamura K, Ishida J, Ishida J, et al: Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study. Oncol Lett 27: 279, 2024.
APA
Kobayashi, K., Einama, T., Tsunenari, T., Yonamine, N., Takao, M., Takihata, Y. ... Kishi, Y. (2024). Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study. Oncology Letters, 27, 279. https://doi.org/10.3892/ol.2024.14412
MLA
Kobayashi, K., Einama, T., Tsunenari, T., Yonamine, N., Takao, M., Takihata, Y., Tsujimoto, H., Ueno, H., Tamura, K., Ishida, J., Kishi, Y."Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study". Oncology Letters 27.6 (2024): 279.
Chicago
Kobayashi, K., Einama, T., Tsunenari, T., Yonamine, N., Takao, M., Takihata, Y., Tsujimoto, H., Ueno, H., Tamura, K., Ishida, J., Kishi, Y."Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study". Oncology Letters 27, no. 6 (2024): 279. https://doi.org/10.3892/ol.2024.14412
Copy and paste a formatted citation
x
Spandidos Publications style
Kobayashi K, Einama T, Tsunenari T, Yonamine N, Takao M, Takihata Y, Tsujimoto H, Ueno H, Tamura K, Ishida J, Ishida J, et al: Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study. Oncol Lett 27: 279, 2024.
APA
Kobayashi, K., Einama, T., Tsunenari, T., Yonamine, N., Takao, M., Takihata, Y. ... Kishi, Y. (2024). Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study. Oncology Letters, 27, 279. https://doi.org/10.3892/ol.2024.14412
MLA
Kobayashi, K., Einama, T., Tsunenari, T., Yonamine, N., Takao, M., Takihata, Y., Tsujimoto, H., Ueno, H., Tamura, K., Ishida, J., Kishi, Y."Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study". Oncology Letters 27.6 (2024): 279.
Chicago
Kobayashi, K., Einama, T., Tsunenari, T., Yonamine, N., Takao, M., Takihata, Y., Tsujimoto, H., Ueno, H., Tamura, K., Ishida, J., Kishi, Y."Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study". Oncology Letters 27, no. 6 (2024): 279. https://doi.org/10.3892/ol.2024.14412
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