Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2024 Volume 27 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2024 Volume 27 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report

  • Authors:
    • Mariana Pilon Capella
    • Parvaneh Fallah
    • Mark Basik
  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Oncology, Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, McGill University Montreal, Montreal, QC H3T 1E2, Canada, Division of Oncology, Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, McGill University Montreal, Montreal, QC H3T 1E2, Canada
  • Article Number: 282
    |
    Published online on: April 25, 2024
       https://doi.org/10.3892/ol.2024.14415
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The detection of circulating tumor DNA (ctDNA) in the plasma of cancer patients is emerging as a very sensitive and specific prognostic biomarker. Previous studies with ctDNA have focused on the ability of ctDNA detection to predict micrometastatic and eventual clinical metastatic relapse. There are few data on the role of ctDNA in monitoring response to local therapy. The present study reports the case of a patient with early‑stage lobular breast cancer, with a detectable ctDNA test which resolved with local radiotherapy to the breast. This case suggests that ctDNA is sensitive enough to detect the response of minimal residual disease, localized in the breast, to radiation therapy, and thus may assist in providing indications for local breast cancer treatment.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Mouabbi JA, Hassan A, Lim B, Hortobagyi GN, Tripathy D and Layman RM: Invasive lobular carcinoma: An understudied emergent subtype of breast cancer. Breast Cancer Res Treat. 193:253–264. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Thomas M, Kelly ED, Abraham J and Kruse M: Invasive lobular breast cancer: A review of pathogenesis, diagnosis, management, and future directions of early stage disease. Semin Oncol. 46:121–132. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Wilson N, Ironside A, Diana A and Oikonomidou O: Lobular breast cancer: A review. Front Oncol. 10:5913992021. View Article : Google Scholar : PubMed/NCBI

5 

Pramod N, Nigam A, Basree M, Mawalkar R, Mehra S, Shinde N, Tozbikian G, Williams N, Majumder S and Ramaswamy B: Comprehensive review of molecular mechanisms and clinical features of invasive lobular cancer. Oncologist. 26:e943–e953. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Biglia N, Maggiorotto F, Liberale V, Bounous VE, Sgro LG, Pecchio S, D'Alonzo M and Ponzone R: Clinical-pathologic features, long term-outcome and surgical treatment in a large series of patients with invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC). Eur J Surg Oncol. 39:455–460. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Choi YJ, Shin YD and Song YJ: Comparison of ipsilateral breast tumor recurrence after breast-conserving surgery between ductal carcinoma in situ and invasive breast cancer. World J Surg Oncol. 14:1262016. View Article : Google Scholar : PubMed/NCBI

8 

Giannakeas V, Sopik V and Narod SA: Association of radiotherapy with survival in women treated for ductal carcinoma in situ with lumpectomy or mastectomy. JAMA Netw Open. 1:e1811002018. View Article : Google Scholar : PubMed/NCBI

9 

Boyages J and Baker L: Evolution of radiotherapy techniques in breast conservation treatment. Gland Surg. 7:5762018. View Article : Google Scholar : PubMed/NCBI

10 

Tsai CJ, Huang HY, Chen FM, Yang YH, Chen LC and Hsieh KP: Investigating the effectiveness of adjuvant therapy for patients with hormone receptor-positive ductal carcinoma in situ. PLoS One. 17:e02629342022. View Article : Google Scholar : PubMed/NCBI

11 

Mills MN, Russo NW, Fahey M, Nanda RH, Raiker S, Jastrzebski J, Stout LL, Wilson JP, Altoos TA, Allen KG, et al: Increased risk for ipsilateral breast tumor recurrence in invasive lobular carcinoma after accelerated partial breast irradiation brachytherapy. Oncologist. 26:e1931–e1938. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Sanz-Garcia E, Zhao E, Bratman SV and Siu LL: Monitoring and adapting cancer treatment using circulating tumor DNA kinetics: Current research, opportunities, and challenges. Sci Adv. 8:eabi86182022. View Article : Google Scholar : PubMed/NCBI

13 

Zavarykina TM, Lomskova PK, Pronina IV, Khokhlova SV, Stenina MB and Sukhikh GT: Circulating tumor DNA is a variant of liquid biopsy with predictive and prognostic clinical value in breast cancer patients. Int J Mol Sci. 24:170732023. View Article : Google Scholar : PubMed/NCBI

14 

Arisi MF, Dotan E and Fernandez SV: Circulating tumor DNA in precision oncology and its applications in colorectal cancer. Int J Mol Sci. 23:44412022. View Article : Google Scholar : PubMed/NCBI

15 

Reinert T, Henriksen TV, Christensen E, Sharma S, Salari R, Sethi H, Knudsen M, Nordentoft I, Wu HT, Tin AS, et al: Analysis of plasma cell-free DNA by ultradeep sequencing in patients with stages I to III colorectal cancer. JAMA Oncol. 5:1124–1131. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Wolff AC, Hammond MEH, Hicks DG, Dowsett M, McShane LM, Allison KH, Allred DC, Bertlett JMS, Bilous M, Fitzgibbons P, et al: Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update. J Clin Oncol. 31:3997–4013. 2013. View Article : Google Scholar : PubMed/NCBI

17 

D'Orsi C, Bassett L and Feig S: Breast imaging reporting and data system (BI-RADS). Breast Imaging Atlas. 4th edition. American College of Radiology; Reston, VA, USA: pp. 29–47. 2018

18 

Amin MD, Gress DM, Meyer Vega LR, Edge SB, Greene FL, Byrd DR, Brookland RK, Washington MK and Compton CC; American Joint Committee on Cancer (AJCC), : AJCC cancer staging manual. 8th edition. Springer; New York, NY, USA: pp. 10322017

19 

Olsson E, Winter C, George A, Chen Y, Howlin J, Tang MH, Dahlgren M, Schulz R, Grabau D and van Westen D: Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease. EMBO Mol Med. 7:1034–1047. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Vlataki K, Antonouli S, Kalyvioti C, Lampri E, Kamina S, Mauri D, Harissis HV and Magklara A: Circulating tumor DNA in the management of early-stage breast cancer. Cells. 12:15732023. View Article : Google Scholar : PubMed/NCBI

21 

Magbanua MJM, Swigart LB, Wu HT, Hirst GL, Yau C, Wolf DM, Tin A, Salari R, Shchegrova S, Pawar H, et al: Circulating tumor DNA in neoadjuvant-treated breast cancer reflects response and survival. Ann Oncol. 32:229–239. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Fiste O, Liontos M, Koutsoukos K, Terpos E, Dimopoulos MA and Zagouri F: Circulating tumor DNA-based predictive biomarkers in breast cancer clinical trials: A narrative review. Ann Transl Med. 8:16032020. View Article : Google Scholar : PubMed/NCBI

23 

Adejolu M, Huo L, Rohren E, Santiago L and Yang WT: False-positive lesions mimicking breast cancer on FDG PET and PET/CT. AJR Am J Roentgenol. 198:W304–W314. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Garcia-Murillas I, Schiavon G, Weigelt B, Ng C, Hrebien S, Cutts RJ, Cheang M, Osin P, Nerurkar A, Kozarewa I, et al: Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer. Sci Transl Med. 7:302ra1332015. View Article : Google Scholar : PubMed/NCBI

25 

Lipsyc-Sharf M, de Bruin EC, Santos K, McEwen R, Stetson D, Patel A, Kirkner GJ, Hughes ME, Tolaney SM, Partridge AH, et al: Circulating tumor DNA and late recurrence in high-risk hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer. J Clin Oncol. 40:2408–2419. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Magbanua MJM, van't Veer L, Clark AS, Chien AJ, Boughey JC, Han HS, Wallace A, Beckwith H, Liu MC, Yau C, et al: Outcomes and clinicopathologic characteristics associated with disseminated tumor cells in bone marrow after neoadjuvant chemotherapy in high-risk early stage breast cancer: The I-SPY SURMOUNT study. Breast Cancer Res Treat. 198:383–390. 2023. View Article : Google Scholar : PubMed/NCBI

27 

Cavallone L, Aguilar-Mahecha A, Lafleur J, Brousse S, Aldamry M, Roseshter T, Lan C, Alirezaie N, Bareke E, Majewski J, et al: Prognostic and predictive value of circulating tumor DNA during neoadjuvant chemotherapy for triple negative breast cancer. Sci Rep. 10:147042020. View Article : Google Scholar : PubMed/NCBI

28 

Coombes RC, Page K, Salari R, Hastings RK, Armstrong A, Ahmed S, Ali S, Cleator S, Kenny L, Stebbing J, et al: Personalized detection of circulating tumor DNA antedates breast cancer metastatic recurrence. Clin Cancer Res. 25:4255–4263. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Cailleux F, Agostinetto E, Lambertini M, Rothé F, Wu HT, Balcioglu M, Kalashnikova E, Vincent D, Viglietti G, Gombos A, et al: Circulating tumor DNA after neoadjuvant chemotherapy in breast cancer is associated with disease relapse. JCO Precis Oncol. 6:e22001482022. View Article : Google Scholar : PubMed/NCBI

30 

Lin PH, Wang MY, Lo C, Tsai LW, Yen TC, Huang TY, Huang WC, Yang K, Chen CK, Fan SC, et al: Circulating tumor DNA as a predictive marker of recurrence for patients with stage II–III breast cancer treated with neoadjuvant therapy. Front Oncol. 11:7367692021. View Article : Google Scholar : PubMed/NCBI

31 

Lee TH, Kim H, Kim YJ, Park WY, Park W, Cho WK and Kim N: Implication of pre- and post-radiotherapy ctDNA dynamics in patients with residual triple-negative breast cancer at surgery after neoadjuvant chemotherapy: Findings from a prospective observational study. Cancer Res Treat. Nov 10–2023.(Epub ahead of print).

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Capella MP, Fallah P and Basik M: Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report. Oncol Lett 27: 282, 2024.
APA
Capella, M.P., Fallah, P., & Basik, M. (2024). Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report. Oncology Letters, 27, 282. https://doi.org/10.3892/ol.2024.14415
MLA
Capella, M. P., Fallah, P., Basik, M."Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report". Oncology Letters 27.6 (2024): 282.
Chicago
Capella, M. P., Fallah, P., Basik, M."Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report". Oncology Letters 27, no. 6 (2024): 282. https://doi.org/10.3892/ol.2024.14415
Copy and paste a formatted citation
x
Spandidos Publications style
Capella MP, Fallah P and Basik M: Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report. Oncol Lett 27: 282, 2024.
APA
Capella, M.P., Fallah, P., & Basik, M. (2024). Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report. Oncology Letters, 27, 282. https://doi.org/10.3892/ol.2024.14415
MLA
Capella, M. P., Fallah, P., Basik, M."Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report". Oncology Letters 27.6 (2024): 282.
Chicago
Capella, M. P., Fallah, P., Basik, M."Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report". Oncology Letters 27, no. 6 (2024): 282. https://doi.org/10.3892/ol.2024.14415
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team