Analysis of the clinicopathological features of tailgut cyst with emphasis on the development of neoplastic lesions

Kobayashi,Toshinori; Ishida,Mitsuaki; Miki,Hisanori; Yagyu,Takuki; Hatta,Masahiko; Hamada,Madoka; Hirose,Yoshinobu; Sekimoto,Mitsugu

doi:10.3892/ol.2024.14419

June-2024 Volume 27 Issue 6

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June-2024 Volume 27 Issue 6

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Analysis of the clinicopathological features of tailgut cyst with emphasis on the development of neoplastic lesions

Authors:
- Toshinori Kobayashi
- Mitsuaki Ishida
- Hisanori Miki
- Takuki Yagyu
- Masahiko Hatta
- Madoka Hamada
- Yoshinobu Hirose
- Mitsugu Sekimoto
View Affiliations / Copyright

Affiliations: Department of Surgery, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan, Department of Pathology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569‑8686, Japan

Copyright: © Kobayashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 286
|
Published online on: April 26, 2024

https://doi.org/10.3892/ol.2024.14419
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Abstract

Tailgut cyst is a rare congenital cyst occurring in the retrorectal space and development of neoplastic lesions in tailgut cyst has been reported. Due to the rarity of the tumor, the histogenesis of neoplastic lesions in tailgut cyst has remained elusive. In the present study, the clinicopathological features of tailgut cyst were analyzed with a particular focus on the development of neoplastic lesions. The clinicopathological features of four patients with tailgut cyst (one female and three males) were retrospectively reviewed. No symptoms were present in two patients. Perineal discomfort, and constipation and urinary retention, were described in the other two patients, respectively. Magnetic resonance imaging showed that the cystic lesions were hypointense on T1‑ and hyperintense on T2‑weigted images in all patients. Histopathological analysis revealed that all lesions were multilocular, and cystic walls were covered by squamous and ciliated epithelia without nuclear atypia. The development of neoplastic lesions was noted in two patients. Dysplastic change composed of piling‑up proliferation of glandular cells with mild to moderate nuclear atypia was present in one patient, and invasive adenocarcinoma with a dysplasia component was observed in another patient. Dysplasia of the glandular cells, as seen in two patients in the present series, may be a precursor lesion of invasive adenocarcinoma; therefore, adenocarcinoma arsing in tailgut cyst may show a dysplasia‑carcinoma sequence. While the reported incidence of neoplastic lesions in tailgut cysts is ~9% or less, their frequency remains to be accurately determined. Therefore, complete surgical resection is important for the management of patients with tailgut cyst. Additional clinicopathological and molecular studies with large cohorts may be required to clarify the histogenesis of neoplastic lesion in tailgut cyst.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Analysis of the clinicopathological features of tailgut cyst with emphasis on the development of neoplastic lesions

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