Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2024 Volume 27 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2024 Volume 27 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Mechanism of isoflurane‑mediated breast cancer growth in vivo

  • Authors:
    • Sophia Koutsogiannaki
    • Wei Wang
    • Lifei Hou
    • Toshiaki Okuno
    • Koichi Yuki
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, MA 02115, USA, Department of Biochemistry, Juntendo University Faculty of Medicine, Tokyo 113‑8421, Japan
  • Article Number: 287
    |
    Published online on: April 30, 2024
       https://doi.org/10.3892/ol.2024.14420
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Use of volatile anesthetics is associated with worse outcome following tumor resection surgery compared with the use of intravenous anesthetics. However, the underlying mechanism has not been clearly delineated yet in vivo. The EO771 cell‑based congenic breast cancer model was used in the present study. Isoflurane directly binds to and inhibits two adhesion molecules, leukocyte function‑associated antigen‑1 (LFA‑1) and macrophage‑1 antigen (Mac‑1). Similarly, exposure to sevoflurane, another volatile anesthetic and LFA‑1 inhibitor, is associated with an increase in breast cancer size compared with non‑exposure. Thus, the present study first examined the role of LFA‑1 and Mac‑1 in the EO771 breast cancer model. Both LFA‑1 deficiency and inhibition enhanced tumor growth, which was supported by cytokine and eicosanoid data profiles. By contrast, Mac‑1 deficiency did not affect tumor growth. The exposure to isoflurane and sevoflurane was associated with an increase in breast cancer size compared with non‑exposure. These data suggested that isoflurane enhanced tumor growth by interacting with LFA‑1. Isoflurane exposure did not affect tumor growth in LFA‑1‑deficient mice. In summary, the present data showed that LFA‑1 deficiency facilitated breast cancer growth, and isoflurane, an LFA‑1 inhibitor, also increased breast cancer growth.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Wigmore TJ, Mohammed K and Jhanji S: Long-term survival for patients undergoing volatile versus IV anesthesia for cancer surgery: A retrospective analysis. Anesthesiology. 124:69–79. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Jun IJ, Jo JY, Kim JI, Chin JH, Kim WJ, Kim HR, Lee EH and Choi IC: Impact of anesthetic agents on overall and recurrence-free survival in patients undergoing esophageal cancer surgery: A retrospective observational study. Sci Rep. 7:140202017. View Article : Google Scholar : PubMed/NCBI

3 

Wu ZF, Lee MS, Wong CS, Lu CH, Huang YS, Lin KT, Lou YS, Lin C, Chang YC and Lai HC: Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in colon cancer surgery. Anesthesiology. 129:932–941. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A and Bray F: Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 144:1941–1953. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Sakamoto K, Schmidt JW and Wagner KU: Mouse models of breast cancer. Methods Mol Biol. 1267:47–71. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Casey AE, Laster WR Jr and Ross GL: Sustained enhanced growth of carcinoma EO771 in C57 black mice. Proc Soc Exp Biol Med. 77:358–362. 1951. View Article : Google Scholar : PubMed/NCBI

7 

Johnstone CN, Smith YE, Cao Y, Burrows AD, Cross RS, Ling X, Redvers RP, Doherty JP, Eckhardt BL, Natoli AL, et al: Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer. Dis Model Mech. 8:237–251. 2015.PubMed/NCBI

8 

Stollings LM, Jia LJ, Tang P, Dou H, Lu B and Xu Y: Immune modulation by volatile anesthetics. Anesthesiology. 125:399–411. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Yuki K and Eckenhoff RG: Mechanisms of the immunological effects of volatile anesthetics: A review. Anesth Analg. 123:326–335. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Yuki K, Astrof NS, Bracken C, Soriano SG and Shimaoka M: Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology. 113:600–609. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Yuki K, Astrof NS, Bracken C, Yoo R, Silkworth W, Soriano SG and Shimaoka M: The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 22:4109–4116. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Yuki K, Bu W, Xi J, Sen M, Shimaoka M and Eckenhoff RG: Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. FASEB J. 26:4408–4417. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Jung S and Yuki K: Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen. J Immunotoxicol. 13:148–156. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Shimaoka M and Springer TA: Therapeutic antagonists and conformational regulation of integrin function. Nat Rev Drug Discov. 2:703–716. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Ho MK and Springer TA: Mac-1 antigen: quantitative expression in macrophage populations and tissues, and immunofluorescent localization in spleen. J Immunol. 128:2281–2286. 1982. View Article : Google Scholar : PubMed/NCBI

16 

Ding ZM, Babensee JE, Simon SI, Lu H, Perrard JL, Bullard DC, Dai XY, Bromley SK, Dustin ML, Entman ML, et al: Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol. 163:5029–5038. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, von Andrian UH, Arnaout MA and Mayadas TN: A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation. Immunity. 5:653–666. 1996. View Article : Google Scholar : PubMed/NCBI

18 

Berrueta L, Bergholz J, Munoz D, Muskaj I, Badger GJ, Shukla A, Kim HJ, Zhao JJ and Langevin HM: Stretching reduces tumor growth in a mouse breast cancer model. Sci Rep. 8:78642018. View Article : Google Scholar : PubMed/NCBI

19 

Tomayko MM and Reynolds CP: Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol. 24:148–154. 1989. View Article : Google Scholar : PubMed/NCBI

20 

Sonner JM, Gong D, Li J, Eger EI II and Laster MJ: Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds. Anesth Analg. 89:1030–1034. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Dahan A, Sarton E, Teppema L, Olievier C, Nieuwenhuijs D, Matthes HW and Kieffer BL: Anesthetic potency and influence of morphine and sevoflurane on respiration in mu-opioid receptor knockout mice. Anesthesiology. 94:824–832. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Okuno T, Koutsogiannaki S, Hou L, Bu W, Ohto U, Eckenhoff RG, Yokomizo T and Yuki K: Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system. FASEB J. 33:14528–14541. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Zha H, Matsunami E, Blazon-Brown N, Koutsogiannaki S, Hou L, Bu W, Babazada H, Odegard KC, Liu R, Eckenhoff RG and Yuki K: Volatile anesthetics affect macrophage phagocytosis. PLoS One. 14:e02161632019. View Article : Google Scholar : PubMed/NCBI

25 

Yuki K, Bu W, Shimaoka M and Eckenhoff R: Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. PLoS One. 8:e604152013. View Article : Google Scholar : PubMed/NCBI

26 

Walker OL, Dahn ML, Power Coombs MR and Marcato P: The prostaglandin E2 pathway and breast cancer stem cells: Evidence of increased signaling and potential targeting. Front Oncol. 11:7916962022. View Article : Google Scholar : PubMed/NCBI

27 

Akaydin S, Ramazanoğlu S, Salihoğlu EM, Karanlik H and Demokan S: Leukotriene D4 levels in patients with breast cancer. FABAD J Pharm Sci. 47:331–338. 2022.

28 

Yuki K: The role of general anesthetic drug selection in cancer outcome. Biomed Res Int. 2021:25630932021. View Article : Google Scholar : PubMed/NCBI

29 

Koutsogiannaki S, Schaefers MM, Okuno T, Ohba M, Yokomizo T, Priebe GP, DiNardo JA, Sulpicio SG and Yuki K: From the cover: Prolonged exposure to volatile anesthetic isoflurane worsens the outcome of polymicrobial abdominal sepsis. Toxicol Sci. 156:402–411. 2017.PubMed/NCBI

30 

Tazawa K, Koutsogiannaki S, Chamberlain M and Yuki K: The effect of different anesthetics on tumor cytotoxicity by natural killer cells. Toxicol Lett. 266:23–31. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Barber DF, Faure M and Long EO: LFA-1 contributes an early signal for NK cell cytotoxicity. J Immunol. 173:3653–3659. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Gao N, Wang C, Yu Y, Xie L, Xing Y, Zhang Y, Wang Y, Wu J and Cai Y: LFA-1/ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model. PLoS Negl Trop Dis. 16:e00108482022. View Article : Google Scholar : PubMed/NCBI

33 

Hickman A, Koetsier J, Kurtanich T, Nielsen MC, Winn G, Wang Y, Bentebibel SE, Shi L, Punt S, Williams L, et al: LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade. J Clin Invest. 132:e1541522022. View Article : Google Scholar : PubMed/NCBI

34 

Hedrick CC and Malanchi I: Neutrophils in cancer: Heterogeneous and multifaceted. Nat Rev Immunol. 22:173–187. 2022. View Article : Google Scholar : PubMed/NCBI

35 

DeNardo DG and Ruffell B: Macrophages as regulators of tumour immunity and immunotherapy. Nat Rev Immunol. 19:369–382. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Tai LH, Tanese de Souza C, Sahi S, Zhang J, Alkayyal AA, Ananth AA and Auer RA: A mouse tumor model of surgical stress to explore the mechanisms of postoperative immunosuppression and evaluate novel perioperative immunotherapies. J Vis Exp. 512532014.PubMed/NCBI

37 

Guo P, Huang J, Wang L, Jia D, Yang J, Dillon DA, Zurakowski D, Mao H, Moses MA and Auguste DT: ICAM-1 as a molecular target for triple negative breast cancer. Proc Natl Acad Sci USA. 111:14710–14715. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Koutsogiannaki S, Wang W, Hou L, Okuno T and Yuki K: Mechanism of isoflurane‑mediated breast cancer growth <em>in vivo</em>. Oncol Lett 27: 287, 2024.
APA
Koutsogiannaki, S., Wang, W., Hou, L., Okuno, T., & Yuki, K. (2024). Mechanism of isoflurane‑mediated breast cancer growth <em>in vivo</em>. Oncology Letters, 27, 287. https://doi.org/10.3892/ol.2024.14420
MLA
Koutsogiannaki, S., Wang, W., Hou, L., Okuno, T., Yuki, K."Mechanism of isoflurane‑mediated breast cancer growth <em>in vivo</em>". Oncology Letters 27.6 (2024): 287.
Chicago
Koutsogiannaki, S., Wang, W., Hou, L., Okuno, T., Yuki, K."Mechanism of isoflurane‑mediated breast cancer growth <em>in vivo</em>". Oncology Letters 27, no. 6 (2024): 287. https://doi.org/10.3892/ol.2024.14420
Copy and paste a formatted citation
x
Spandidos Publications style
Koutsogiannaki S, Wang W, Hou L, Okuno T and Yuki K: Mechanism of isoflurane‑mediated breast cancer growth <em>in vivo</em>. Oncol Lett 27: 287, 2024.
APA
Koutsogiannaki, S., Wang, W., Hou, L., Okuno, T., & Yuki, K. (2024). Mechanism of isoflurane‑mediated breast cancer growth <em>in vivo</em>. Oncology Letters, 27, 287. https://doi.org/10.3892/ol.2024.14420
MLA
Koutsogiannaki, S., Wang, W., Hou, L., Okuno, T., Yuki, K."Mechanism of isoflurane‑mediated breast cancer growth <em>in vivo</em>". Oncology Letters 27.6 (2024): 287.
Chicago
Koutsogiannaki, S., Wang, W., Hou, L., Okuno, T., Yuki, K."Mechanism of isoflurane‑mediated breast cancer growth <em>in vivo</em>". Oncology Letters 27, no. 6 (2024): 287. https://doi.org/10.3892/ol.2024.14420
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team