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Case Report Open Access

Superficial CD34+ fibroblastic tumor with focal atypical presentation: A case report

  • Authors:
    • Juan Sun
    • Shengliang Huang
    • Xiaoqing Yang
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Jinan First People's Hospital, Jinan, Shandong 250014, P.R. China, Department of Urology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China, Department of Pathology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 335
    |
    Published online on: May 22, 2024
       https://doi.org/10.3892/ol.2024.14468
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Abstract

Superficial CD34+ fibroblastic tumors (SCPFTs) are rare mesenchymal tumors with distinct morphological features. Although several cases of SCPFT have been reported, a comprehensive understanding of its clinical and biological features necessitates the inclusion of additional cases. The current study presents a case of SCPFT, where morphological observations, immunohistochemical staining and fluorescence in situ hybridization (FISH) were performed. Immunohistochemistry revealed diffuse CD34 expression and integrase interactor 1 expression, whilst FISH indicated rearrangement of the PR/SET domain 10 gene. Microscopic assessment demonstrated typical SCPFT pathology, with a focal nodular region showing a high Ki‑67 index, suggesting heterogeneity and the potential for local recurrence. The present study also briefly reviews the differential diagnosis of tumors with morphological similarities. It was found that the precise diagnosis of SCPFT relies on the distinctive pathological features, the use of immunohistochemical markers, including CD34 staining, and the differentiation from similar histological lesions.
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Copy and paste a formatted citation
Spandidos Publications style
Sun J, Huang S and Yang X: Superficial CD34<sup>+</sup> fibroblastic tumor with focal atypical presentation: A case report. Oncol Lett 28: 335, 2024.
APA
Sun, J., Huang, S., & Yang, X. (2024). Superficial CD34<sup>+</sup> fibroblastic tumor with focal atypical presentation: A case report. Oncology Letters, 28, 335. https://doi.org/10.3892/ol.2024.14468
MLA
Sun, J., Huang, S., Yang, X."Superficial CD34<sup>+</sup> fibroblastic tumor with focal atypical presentation: A case report". Oncology Letters 28.1 (2024): 335.
Chicago
Sun, J., Huang, S., Yang, X."Superficial CD34<sup>+</sup> fibroblastic tumor with focal atypical presentation: A case report". Oncology Letters 28, no. 1 (2024): 335. https://doi.org/10.3892/ol.2024.14468
Copy and paste a formatted citation
x
Spandidos Publications style
Sun J, Huang S and Yang X: Superficial CD34<sup>+</sup> fibroblastic tumor with focal atypical presentation: A case report. Oncol Lett 28: 335, 2024.
APA
Sun, J., Huang, S., & Yang, X. (2024). Superficial CD34<sup>+</sup> fibroblastic tumor with focal atypical presentation: A case report. Oncology Letters, 28, 335. https://doi.org/10.3892/ol.2024.14468
MLA
Sun, J., Huang, S., Yang, X."Superficial CD34<sup>+</sup> fibroblastic tumor with focal atypical presentation: A case report". Oncology Letters 28.1 (2024): 335.
Chicago
Sun, J., Huang, S., Yang, X."Superficial CD34<sup>+</sup> fibroblastic tumor with focal atypical presentation: A case report". Oncology Letters 28, no. 1 (2024): 335. https://doi.org/10.3892/ol.2024.14468
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