Low serum creatine kinase level is associated with poor prognosis in patients with hepatocellular carcinoma: A retrospective single‑center study

Matsumoto,Yu; Otsuka,Yuichiro; Okada,Rei; Ito,Yuko; Kimura,Kazutaka; Ishii,Jun; Maeda,Tetsuya; Tsuchiya,Masaru; Funahashi,Kimihiko; Shimada,Hideaki

doi:10.3892/ol.2024.14587

October-2024 Volume 28 Issue 4

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October-2024 Volume 28 Issue 4

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Article

Low serum creatine kinase level is associated with poor prognosis in patients with hepatocellular carcinoma: A retrospective single‑center study

Authors:
- Yu Matsumoto
- Yuichiro Otsuka
- Rei Okada
- Yuko Ito
- Kazutaka Kimura
- Jun Ishii
- Tetsuya Maeda
- Masaru Tsuchiya
- Kimihiko Funahashi
- Hideaki Shimada
View Affiliations / Copyright

Affiliations: Department of Surgery, Toho University School of Medicine, Tokyo 143‑8541, Japan
Article Number: 454
|
Published online on: July 23, 2024

https://doi.org/10.3892/ol.2024.14587
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Abstract

Previous studies have reported low serum creatine kinase (s‑CK) levels as a poor prognostic factor in various cancers. However, there have been no reports on its significance in hepatocellular carcinoma. The present study aimed to evaluate the association of the preoperative s‑CK levels with clinicopathologic features and their prognostic impact on survival in patients with hepatocellular carcinoma. This retrospective study included 163 patients with hepatocellular carcinoma (127 male and 36 female patients; median age, 69 years) who underwent radical liver resection between January 2004 and December 2021. A cutoff preoperative s‑CK level of 91 U/l determined by receiver operating characteristic curve analysis was used to evaluate the significance of s‑CK in predicting overall and recurrence‑free survival. In addition, the prognostic impact of s‑CK was evaluated using univariate and multivariate analysis. s‑CK level was not associated with clinicopathologic factors. Overall survival and recurrence‑free survival of the low s‑CK group were significantly worse compared with the high s‑CK group (P=0.043 and P=0.029, respectively). By multivariate analysis, low s‑CK was an independent risk factor for poor overall survival and recurrence‑free survival (P=0.019 and P=0.014, respectively). This trend was the same for male patients, but no significant difference was observed for female patients. Low preoperative s‑CK level might be a poor prognostic biomarker in patients with hepatocellular carcinoma.

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1	Yan YB: Creatine kinase in cell cycle regulation and cancer. Amino Acids. 48:1775–1784. 2016. View Article : Google Scholar : PubMed/NCBI
2	Kazak L and Cohen P: Creatine metabolism: Energy homeostasis, immunity and cancer biology. Nat Rev Endocrinol. 16:421–436. 2020. View Article : Google Scholar : PubMed/NCBI
3	Murayama K, Suzuki T, Yajima S, Oshima Y, Nanami T, Shiratori F and Shimada H: Preoperative low serum creatine kinase is associated with poor overall survival in the male patients with esophageal squamous cell carcinoma. Esophagus. 12:105–112. 2022. View Article : Google Scholar
4	Yamazaki N, Oshima Y, Shiratori F, Nanami T, Suzuki T, Yajima S, Funahashi K and Shimada H: Prognostic significance of preoperative low serum creatine kinase levels in gastric cancer. Surg Today. 52:1551–1559. 2022. View Article : Google Scholar : PubMed/NCBI
5	Pan H, Xia K, Zhou W, Xue J, Liang X, Chen L, Wu N, Liang M, Wu D, Ling L, et al: Low serum creatine kinase levels in breast cancer patients: A case-control study. PLoS One. 8:e621122013. View Article : Google Scholar : PubMed/NCBI
6	Liu L, He Y, Ge G, Li L, Zhou P, Zhu Y, Tang H, Huang Y, Li W and Zhang: Lactate dehydrogenase and creatine kinase as poor prognostic factors in lung cancer: A retrospective observational study. PLoS One. 12:e01821682017. View Article : Google Scholar : PubMed/NCBI
7	Takamori S, Toyokawa G, Shimokawa M, Kinoshita F, Kazuma Y, Matsubara T, Haratake N, Akamine T, Hirai F, Tagawa T, et al: A novel prognostic marker in patients with non-small cell lung cancer: Musculo- immuno-nutritional score calculated by controlling nutritional status and creatine kinase. J Thorac Dis. 11:927–935. 2019. View Article : Google Scholar : PubMed/NCBI
8	Forner A, Reig M and Bruix J: Hepatocellular carcinoma. Lancet. 391:1301–1314. 2018. View Article : Google Scholar : PubMed/NCBI
9	Qin LX and Tang ZY: The prognostic significance of clinical and pathological features in hepatocellular carcinoma. World J Gastroenterol. 8:193–199. 2002. View Article : Google Scholar : PubMed/NCBI
10	Befeler AS and Di Bisceglie AM: Hepatocellular carcinoma: Diagnosis and treatment. Gastroenterology. 122:1609–1610. 2002. View Article : Google Scholar : PubMed/NCBI
11	Ho EY, Cozen ML, Shen H, Lerrigo R, Trimble E, Ryan JC, Covera CU and Monto A; HOVAS Group (Hepatocellular Carcinoma Treatment Outcome at VA San Francisco), : Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma. HPB (Oxford). 16:758–767. 2015. View Article : Google Scholar
12	Liu Y, Shi M, Chen S, Wan W, Shen L, Shen B, Qui H, Cao F, Wu Y, Huang T, et al: Intermediate stage hepatocellular carcinoma: Comparison of the value of inflammation-based scores in predicting progression-free survival of patients receiving transarterial chemoembolization. J Cancer Res Ther. 17:740–748. 2021. View Article : Google Scholar : PubMed/NCBI
13	Yanagaki M, Haruki K, Taniai T, Igarashi Y, Yasuda J, Furukawa K, Onda S, Shirai Y and Tsunematsu M: The significance of osteosarcopenia as a predictor of the long-term outcomes in hepatocellular carcinoma after hepatic resection. J Hepatobiliary Pancreat Sci. 30:453–461. 2023. View Article : Google Scholar : PubMed/NCBI
14	Kanemitsu F, Kawanishi I, Mizushima J and Okigaki T: Mitochondrial creatine kinase as a tumor-associated marker. Clin Chim Acta. 138:175–183. 1984. View Article : Google Scholar : PubMed/NCBI
15	Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013. View Article : Google Scholar : PubMed/NCBI
16	Neal RC, Ferdinand KC, Ycas J and Miller E: Relationship of ethnic origin, gender, and age to blood creatine kinase levels. Am J Med. 122:73–78. 2009. View Article : Google Scholar : PubMed/NCBI
17	Hackney AC, Kallman AL and Ağgön E: Female sex hormones and the recovery from: Menstrual cycle phase affects responses. Biomed Hum Kinet. 11:87–89. 2019. View Article : Google Scholar : PubMed/NCBI
18	Chen C, Lin X, Lin R, Huang H and Lu F: A high serum creatine kinase (CK)-MB-to-total-CK ratio in patients with pancreatic cancer: A novel application of a traditional marker in predicting malignancy of pancreatic masses? World J Surg Oncol. 21:132023. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Low serum creatine kinase level is associated with poor prognosis in patients with hepatocellular carcinoma: A retrospective single‑center study

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