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Myeloid/lymphoid neoplasms with eosinophilia and FGFR1 rearrangement t(8;13)(p11;q12): A case report and literature review

  • Authors:
    • Yu-Jie Guo
    • Meng-Xue Ma
    • Tian Tian
    • Jing-Nan Zhang
    • Xiao-Nan Guo
    • Shukai Qiao
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 468
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    Published online on: July 31, 2024
       https://doi.org/10.3892/ol.2024.14601
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Abstract

8p11 myeloproliferative syndrome (EMS) is a rare and aggressive hematological malignancy, characterized by myeloproliferative neoplasms, and associated with eosinophilia and T‑ or B‑cell lineage lymphoblastic lymphoma. The pathogenesis is defined by the presence of chromosomal translocations associated with the fibroblast growth factor‑1 (FGFR1) gene, located in the 8p11‑12.1 chromosomal locus. At present, only ~100 cases have been reported globally. At least 15 partner genes have been identified, including the most common, the zinc finger MYM‑type containing 2 (ZNF198)‑FGFR1 fusion gene formed by t(8;13)(p11;q12). Different fusion genes determine the clinical manifestations and prognosis of the disease. Patients with EMS with t(8;13)(p11;q12) commonly present with lymphadenopathy and T‑lymphoblastic lymphoma, which usually converts to acute myeloid leukemia (AML) with the progression of the disease. The present study describes the case of an elderly female patient with EMS with t(8;13)(p11;q12), presenting with myeloid/lymphoid syndrome (myeloproliferative neoplasms and T lymphoblastic lymphoma). The patient received the CHOPE regimen combined with tyrosine kinase inhibitor (dasatin) treatment and obtained short‑term complete remission. However, 6 months later, the disease progressed from EMS to AML and the patient died due to ineffective induction therapy. The present study also reviews the relevant literature about this unusual entity to enhance the understanding of EMS.
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Copy and paste a formatted citation
Spandidos Publications style
Guo Y, Ma M, Tian T, Zhang J, Guo X and Qiao S: Myeloid/lymphoid neoplasms with eosinophilia and FGFR1 rearrangement t(8;13)(p11;q12): A case report and literature review. Oncol Lett 28: 468, 2024.
APA
Guo, Y., Ma, M., Tian, T., Zhang, J., Guo, X., & Qiao, S. (2024). Myeloid/lymphoid neoplasms with eosinophilia and FGFR1 rearrangement t(8;13)(p11;q12): A case report and literature review. Oncology Letters, 28, 468. https://doi.org/10.3892/ol.2024.14601
MLA
Guo, Y., Ma, M., Tian, T., Zhang, J., Guo, X., Qiao, S."Myeloid/lymphoid neoplasms with eosinophilia and FGFR1 rearrangement t(8;13)(p11;q12): A case report and literature review". Oncology Letters 28.4 (2024): 468.
Chicago
Guo, Y., Ma, M., Tian, T., Zhang, J., Guo, X., Qiao, S."Myeloid/lymphoid neoplasms with eosinophilia and FGFR1 rearrangement t(8;13)(p11;q12): A case report and literature review". Oncology Letters 28, no. 4 (2024): 468. https://doi.org/10.3892/ol.2024.14601
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Ma M, Tian T, Zhang J, Guo X and Qiao S: Myeloid/lymphoid neoplasms with eosinophilia and FGFR1 rearrangement t(8;13)(p11;q12): A case report and literature review. Oncol Lett 28: 468, 2024.
APA
Guo, Y., Ma, M., Tian, T., Zhang, J., Guo, X., & Qiao, S. (2024). Myeloid/lymphoid neoplasms with eosinophilia and FGFR1 rearrangement t(8;13)(p11;q12): A case report and literature review. Oncology Letters, 28, 468. https://doi.org/10.3892/ol.2024.14601
MLA
Guo, Y., Ma, M., Tian, T., Zhang, J., Guo, X., Qiao, S."Myeloid/lymphoid neoplasms with eosinophilia and FGFR1 rearrangement t(8;13)(p11;q12): A case report and literature review". Oncology Letters 28.4 (2024): 468.
Chicago
Guo, Y., Ma, M., Tian, T., Zhang, J., Guo, X., Qiao, S."Myeloid/lymphoid neoplasms with eosinophilia and FGFR1 rearrangement t(8;13)(p11;q12): A case report and literature review". Oncology Letters 28, no. 4 (2024): 468. https://doi.org/10.3892/ol.2024.14601
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