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NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma

  • Authors:
    • Yang Zhang
    • Jinqi Tu
    • Jian Wang
    • Tiancheng Dai
    • Lin Zheng
    • Sinan Sun
    • Conyin Tu
    • Heng Li
    • Liting Qian
  • View Affiliations / Copyright

    Affiliations: Department of Comprehensive Surgery, The First Affiliated Hospital of University of Science and Technology of China West District, Hefei, Anhui 230031, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui 241001, P.R. China, Department of Medical Laboratory Technology, The First Clinical College of Anhui Medical University, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Radiation Oncology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230031, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 480
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    Published online on: August 6, 2024
       https://doi.org/10.3892/ol.2024.14613
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Abstract

The important role of the nuclear factor κB (NFκB) pathway in tumour development has long been recognized; however, the role of the NFκB inhibitor family in liver cancer has not been elucidated. Hepatocellular carcinoma (HCC) is a serious public health burden with a high incidence, poor prognosis, and early detection, especially in Asia, where hepatitis is prevalent. In the present study, the mRNA expression level of the NFκB inhibitor family was assessed in HCC and normal tissues using the Metabolic Gene Rapid Visualizer, University of Alabama at Birmingham Cancer Data Analysis Portal, and the Tumor Immune Estimation Resource database (TIMER). Survival curves of nuclear factor of κ light polypeptide gene enhancer in B‑cells inhibitor (NFKBI)E were obtained using the Kaplan‑Meier method. Genes co‑expressed with NFKBIE in HCC samples were studied using data from the LinkedOmics and the Hepatocellular Carcinoma Databases. Protein‑protein interaction networks, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment pathway analyses were used to assess the NFKBIE mechanism in HCC. Using the TIMER database, the association between immune infiltration and NFKBIE was determined. RNA‑sequencing (RNA‑seq) was used to evaluate the function of NFKBIE in HCC and its impact on proliferation and migration. Western blotting was used to confirm the expression of NFKBIE in HCC cell lines. In addition, NFKBIE overexpression in HCC was demonstrated using tissue microarrays encompassing 80 pairs of HCC and normal liver tissues. NFKBIE was the only NFκB inhibitor with high expression and an improved prognosis in HCC compared with other NFκB inhibitors. NFKBIE was correlated with clinical characteristics, such as tumour grade, tumour protein P53 mutation status and tumour stage. Data obtained from Gene Set Cancer Analysis suggested that NFKBIE may inhibit the PI3K/AKT, RAS/MAPK, RTK and TSC/mTOR pathways. In addition, NFKBIE was significantly associated with B‑cell immune infiltration and the RNA‑seq data demonstrated that knockdown of NFKBIE significantly affected ‘Antigen processing and presentation’ and ‘hepatocellular carcinoma’ pathways. Immunohistochemistry of microarrays of tissue samples revealed that NFKBIE was overexpressed in several stages of HCC. Finally, inhibition of NFKBIE decreased the proliferation and migration of HCC cells. In conclusion, due to its prognostic value and overexpression in HCC, NFKBIE distinguished itself from other NFκB inhibitors. As such, it may provide a novel prognostic indicator and immunotherapeutic target for HCC.
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View References

1 

Forner A, Llovet JM and Bruix J: Chemoembolization for intermediate HCC: Is there proof of survival benefit? J Hepatol. 56:984–986. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Louafi S, Boige V, Ducreux M, Bonyhay L, Mansourbakht T, de Baere T, Asnacios A, Hannoun L, Poynard T and Taïeb J: Gemcitabine plus oxaliplatin (GEMOX) in patients with advanced hepatocellular carcinoma (HCC): Results of a phase II study. Cancer. 109:1384–1390. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Powell EE, Wong VW and Rinella M: Non-alcoholic fatty liver disease. Lancet. 397:2212–2224. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Han SK, Baik SK and Kim MY: Non-alcoholic fatty liver disease: Definition and subtypes. Clin Mol Hepatol. 29 (Suppl):S5–S16. 2023. View Article : Google Scholar : PubMed/NCBI

5 

Liu SY, Tsai IT and Hsu YC: Alcohol-related liver disease: Basic mechanisms and clinical perspectives. Int J Mol Sci. 22:51702021. View Article : Google Scholar : PubMed/NCBI

6 

Allameh A, Niayesh-Mehr R, Aliarab A, Sebastiani G and Pantopoulos K: Oxidative stress in liver pathophysiology and disease. Antioxidants (Basel). 12:16532023. View Article : Google Scholar : PubMed/NCBI

7 

Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G and Tsukamoto H: Alcoholic liver disease. Nat Rev Dis Primers. 4:162018. View Article : Google Scholar : PubMed/NCBI

8 

Villanueva A: Hepatocellular carcinoma. N Engl J Med. 380:1450–1462. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, Lencioni R, Koike K, Zucman-Rossi J and Finn RS: Hepatocellular carcinoma. Nat Rev Dis Primers. 7:62021. View Article : Google Scholar : PubMed/NCBI

10 

Tan EE, Hopkins RA, Lim CK, Jamuar SS, Ong C, Thoon KC, Koh MJ, Shin EM, Lian DW, Weerasooriya M, et al: Dominant-negative NFKBIA mutation promotes IL-1β production causing hepatic disease with severe immunodeficiency. J Clin Invest. 130:5817–5832. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Hayden MS and Ghosh S: Shared principles in NF-kappaB signaling. Cell. 132:344–362. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X, Zhang J, Ji L, Ren T, An J, et al: Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways. Autophagy. 12:999–1014. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Della-Valle V, Roos-Weil D, Scourzic L, Mouly E, Aid Z, Darwiche W, Lecluse Y, Damm F, Mémet S, Mercher T, et al: Nfkbie-deficiency leads to increased susceptibility to develop B-cell lymphoproliferative disorders in aged mice. Blood Cancer J. 10:382020. View Article : Google Scholar : PubMed/NCBI

14 

Bonato A, Chakraborty S, Bomben R, Canarutto G, Felician G, Martines C, Zucchetto A, Pozzo F, Vujovikj M, Polesel J, et al: NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia. Leukemia. Mar 15–2024.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

15 

Li B, Severson E, Pignon JC, Zhao H, Li T, Novak J, Jiang P, Shen H, Aster JC, Rodig S, et al: Comprehensive analyses of tumor immunity: Implications for cancer immunotherapy. Genome Biol. 17:1742016. View Article : Google Scholar : PubMed/NCBI

16 

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B and Liu XS: TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 77:e108–e110. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M, Katayama T, Kawashima S, Okuda S, Tokimatsu T and Yamanishi Y: KEGG for linking genomes to life and the environment. Nucleic Acids Res. 36((Database Issue)): D480–D484. 2008.PubMed/NCBI

19 

Menyhárt O, Nagy A and Győrffy B: Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma. R Soc Open Sci. 5:1810062018. View Article : Google Scholar : PubMed/NCBI

20 

Shaul YD, Yuan B, Thiru P, Nutter-Upham A, McCallum S, Lanzkron C, Bell GW and Sabatini DM: MERAV: A tool for comparing gene expression across human tissues and cell types. Nucleic Acids Res. 44(D1): D560–D566. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Asplund A, Edqvist PHD, Schwenk JM and Pontén F: Antibodies for profiling the human proteome-the human protein atlas as a resource for cancer research. Proteomics. 12:2067–2077. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Vasaikar SV, Straub P, Wang J and Zhang B: LinkedOmics: Analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res. 46(D1): D956–D963. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Gable AL, Fang T, Doncheva NT, Pyysalo S, et al: The STRING database in 2023: Protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 51(D1): D638–D646. 2023. View Article : Google Scholar : PubMed/NCBI

24 

Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, Doncheva NT, Legeay M, Fang T, Bork P, et al: The STRING database in 2021: Customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res. 49(D1): D605–D612. 2021. View Article : Google Scholar : PubMed/NCBI

25 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C and Jensen LJ: STRING v9.1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41((Database Issue)): D808–D815. 2013.PubMed/NCBI

26 

Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, et al: Genomics of drug sensitivity in cancer (GDSC): A resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 41((Database Issue)): D955–D961. 2013.PubMed/NCBI

27 

Seashore-Ludlow B, Rees MG, Cheah JH, Cokol M, Price EV, Coletti ME, Jones V, Bodycombe NE, Soule CK, Gould J, et al: Harnessing connectivity in a large-scale small-molecule sensitivity dataset. Cancer Discov. 5:1210–1223. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, et al: Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nat Chem Biol. 12:109–116. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Basu A, Bodycombe NE, Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, et al: An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. Cell. 154:1151–1161. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Lian Q, Wang S, Zhang G, Wang D, Luo G, Tang J, Chen L and Gu J: HCCDB: A database of hepatocellular carcinoma expression atlas. Genomics Proteomics Bioinformatics. 16:269–275. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Liu CJ, Hu FF, Xia MX, Han L, Zhang Q and Guo AY: GSCALite: A web server for gene set cancer analysis. Bioinformatics. 34:3771–3772. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e452001. View Article : Google Scholar : PubMed/NCBI

33 

Bolger AM, Lohse M and Usadel B: Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics. 30:2114–2120. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Kim D, Langmead B and Salzberg SL: HISAT: A fast spliced aligner with low memory requirements. Nat Methods. 12:357–360. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Roberts A, Trapnell C, Donaghey J, Rinn JL and Pachter L: Improving RNA-Seq expression estimates by correcting for fragment bias. Genome Biol. 12:R222011. View Article : Google Scholar : PubMed/NCBI

36 

Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ, Salzberg SL, Wold BJ and Pachter L: Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol. 28:511–515. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Anders S, Pyl PT and Huber W: HTSeq-a Python framework to work with high-throughput sequencing data. Bioinformatics. 31:166–169. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Anders S and Huber W: Differential expression of RNA-Seq data at the gene level-the DESeq package. European Molecular Biology Laboratory (EMBL); 2012

39 

The Gene Ontology Consortium: The gene ontology resource: 20 Years and still GOing strong. Nucleic Acids Res. 47(D1): D330–D338. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Global Burden of Disease Liver Cancer Collaboration, . Akinyemiju T, Abera S, Ahmed M, Alam N, Alemayohu MA, Allen C, Al-Raddadi R, Alvis-Guzman N, Amoako Y, et al: The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: Results from the global burden of disease study 2015. JAMA Oncol. 3:1683–1691. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Hunter JE, Leslie J and Perkins ND: c-Rel and its many roles in cancer: An old story with new twists. Br J Cancer. 114:1–6. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Sun SC: The noncanonical NF-κB pathway. Immunol Rev. 246:125–140. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Oeckinghaus A and Ghosh S: The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol. 1:a0000342009. View Article : Google Scholar : PubMed/NCBI

44 

Hayden MS and Ghosh S: NF-κB, the first quarter-century: Remarkable progress and outstanding questions. Genes Dev. 26:203–234. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Zhang M, Huang J, Tan X, Bai J, Wang H, Ge Y, Xiong H, Shi J, Lu W, Lv Z and Liang C: Common polymorphisms in the NFKBIA gene and cancer susceptibility: A meta-analysis. Med Sci Monit. 21:3186–3196. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Souza SP, Splitt SD, Sànchez-Arcila JC, Alvarez JA, Wilson JN, Wizzard S, Luo Z, Baumgarth N and Jensen KDC: Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii. PLoS Pathog. 17:e10100812021. View Article : Google Scholar : PubMed/NCBI

47 

Du C, Duan X, Yao X, Wan J, Cheng Y, Wang Y, Yan Y, Zhang L, Zhu L, Ni C, et al: Tumour-derived exosomal miR-3473b promotes lung tumour cell intrapulmonary colonization by activating the nuclear factor-κB of local fibroblasts. J Cell Mol Med. 24:7802–7813. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Arnold CN, Pirie E, Dosenovic P, McInerney GM, Xia Y, Wang N, Li X, Siggs OM, Karlsson Hedestam GB and Beutler B: A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci USA. 109:12286–12293. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Touma M, Keskin DB, Shiroki F, Saito I, Koyasu S, Reinherz EL and Clayton LK: Impaired B cell development and function in the absence of IkappaBNS. J Immunol. 187:3942–3952. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Mansouri L, Noerenberg D, Young E, Mylonas E, Abdulla M, Frick M, Asmar F, Ljungström V, Schneider M, Yoshida K, et al: Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. Blood. 128:2666–2670. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Chen T, Li J, Xu M, Zhao Q, Hou Y, Yao L, Zhong Y, Chou PC, Zhang W, Zhou P and Jiang Y: PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation. Nat Commun. 8:9392017. View Article : Google Scholar : PubMed/NCBI

52 

Chiao PJ, Na R, Niu J, Sclabas GM, Dong Q and Curley SA: Role of Rel/NF-kappaB transcription factors in apoptosis of human hepatocellular carcinoma cells. Cancer. 95:1696–1705. 2002. View Article : Google Scholar : PubMed/NCBI

53 

Wei X, Xu Y, Xu FF, Chaiswing L, Schnell D, Noel T, Wang C, Chen J, St Clair DK and St Clair WH: RelB expression determines the differential effects of ascorbic acid in normal and cancer cells. Cancer Res. 77:1345–1356. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Karin M, Lawrence T and Nizet V: Innate immunity gone awry: Linking microbial infections to chronic inflammation and cancer. Cell. 124:823–835. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Greten TF, Wang XW and Korangy F: Current concepts of immune based treatments for patients with HCC: From basic science to novel treatment approaches. Gut. 64:842–848. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Buzzetti E, Pinzani M and Tsochatzis EA: The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism. 65:1038–1048. 2016. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Zhang Y, Tu J, Wang J, Dai T, Zheng L, Sun S, Tu C, Li H and Qian L: NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma. Oncol Lett 28: 480, 2024.
APA
Zhang, Y., Tu, J., Wang, J., Dai, T., Zheng, L., Sun, S. ... Qian, L. (2024). NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma. Oncology Letters, 28, 480. https://doi.org/10.3892/ol.2024.14613
MLA
Zhang, Y., Tu, J., Wang, J., Dai, T., Zheng, L., Sun, S., Tu, C., Li, H., Qian, L."NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma". Oncology Letters 28.4 (2024): 480.
Chicago
Zhang, Y., Tu, J., Wang, J., Dai, T., Zheng, L., Sun, S., Tu, C., Li, H., Qian, L."NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma". Oncology Letters 28, no. 4 (2024): 480. https://doi.org/10.3892/ol.2024.14613
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Spandidos Publications style
Zhang Y, Tu J, Wang J, Dai T, Zheng L, Sun S, Tu C, Li H and Qian L: NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma. Oncol Lett 28: 480, 2024.
APA
Zhang, Y., Tu, J., Wang, J., Dai, T., Zheng, L., Sun, S. ... Qian, L. (2024). NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma. Oncology Letters, 28, 480. https://doi.org/10.3892/ol.2024.14613
MLA
Zhang, Y., Tu, J., Wang, J., Dai, T., Zheng, L., Sun, S., Tu, C., Li, H., Qian, L."NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma". Oncology Letters 28.4 (2024): 480.
Chicago
Zhang, Y., Tu, J., Wang, J., Dai, T., Zheng, L., Sun, S., Tu, C., Li, H., Qian, L."NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma". Oncology Letters 28, no. 4 (2024): 480. https://doi.org/10.3892/ol.2024.14613
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