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Review Open Access

Anticancer role of flubendazole: Effects and molecular mechanisms (Review)

  • Authors:
    • Xing Xing
    • Zongning Zhou
    • Hongwei Peng
    • Shaoping Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China, Human Genetic Resources Preservation Center of Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Xing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 558
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    Published online on: September 20, 2024
       https://doi.org/10.3892/ol.2024.14691
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Abstract

Flubendazole, an anthelmintic agent with a well‑established safety profile, has emerged as a promising anticancer drug that has demonstrated efficacy against a spectrum of cancer types over the past decade. Its anticancer properties encompass a multifaceted mechanism of action, including the inhibition of cancer cell proliferation, disruption of microtubule dynamics, regulation of cell cycle, autophagy, apoptosis, suppression of cancer stem cell characteristics, promotion of ferroptosis and inhibition of angiogenesis. The present review aimed to provide a comprehensive overview of the molecular underpinnings of the anticancer activity of flubendazole, highlighting key molecules and regulatory pathways. Given the breadth of the potential of flubendazole, further research is imperative to identify additional cancer types sensitive to flubendazole, refine experimental methodologies for enhancing its reliability, uncover synergistic drug combinations, improve its bioavailability and explore innovative administration methods. The present review provided a foundation for future studies on the role of flubendazole in oncology and described its molecular mechanisms of action.
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Copy and paste a formatted citation
Spandidos Publications style
Xing X, Zhou Z, Peng H and Cheng S: Anticancer role of flubendazole: Effects and molecular mechanisms (Review). Oncol Lett 28: 558, 2024.
APA
Xing, X., Zhou, Z., Peng, H., & Cheng, S. (2024). Anticancer role of flubendazole: Effects and molecular mechanisms (Review). Oncology Letters, 28, 558. https://doi.org/10.3892/ol.2024.14691
MLA
Xing, X., Zhou, Z., Peng, H., Cheng, S."Anticancer role of flubendazole: Effects and molecular mechanisms (Review)". Oncology Letters 28.6 (2024): 558.
Chicago
Xing, X., Zhou, Z., Peng, H., Cheng, S."Anticancer role of flubendazole: Effects and molecular mechanisms (Review)". Oncology Letters 28, no. 6 (2024): 558. https://doi.org/10.3892/ol.2024.14691
Copy and paste a formatted citation
x
Spandidos Publications style
Xing X, Zhou Z, Peng H and Cheng S: Anticancer role of flubendazole: Effects and molecular mechanisms (Review). Oncol Lett 28: 558, 2024.
APA
Xing, X., Zhou, Z., Peng, H., & Cheng, S. (2024). Anticancer role of flubendazole: Effects and molecular mechanisms (Review). Oncology Letters, 28, 558. https://doi.org/10.3892/ol.2024.14691
MLA
Xing, X., Zhou, Z., Peng, H., Cheng, S."Anticancer role of flubendazole: Effects and molecular mechanisms (Review)". Oncology Letters 28.6 (2024): 558.
Chicago
Xing, X., Zhou, Z., Peng, H., Cheng, S."Anticancer role of flubendazole: Effects and molecular mechanisms (Review)". Oncology Letters 28, no. 6 (2024): 558. https://doi.org/10.3892/ol.2024.14691
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