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Article Open Access

Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths

  • Authors:
    • Chiyo Nakashima
    • Michihisa Iida
    • Mitsuo Nishiyama
    • Yusaku Watanabe
    • Yoshitaro Shindo
    • Yukio Tokumitsu
    • Shinobu Tomochika
    • Yuki Nakagami
    • Hidenori Takahashi
    • Hiroaki Nagano
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755‑8505, Japan
    Copyright: © Nakashima et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 562
    |
    Published online on: September 26, 2024
       https://doi.org/10.3892/ol.2024.14695
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Abstract

 Infectious complications (ICs) have been reported as major causes of postoperative mortality in patients with cancer. However, to the best of our knowledge, the impact of ICs after gastrectomy on non‑gastric cancer‑related deaths (NGCDs) remains unexplored. The present study aimed to identify the impact of ICs after gastrectomy on NGCDs. A retrospective analysis of 712 patients with gastric cancer who underwent curative gastrectomy was conducted. The participants were categorized into IC and non‑IC groups based on the incidence of postoperative IC. Clinicopathological factors and non‑gastric cancer‑related survival (NGCS) rates were compared between groups. Further NGCD and associated risk factor analyses were performed in a background factor‑adjusted cohort using multivariate analysis. Among the 712 patients, 112 developed ICs (Clavien‑Dindo classification grade ≥II). In the entire cohort, the IC group had a significantly worse 5‑year cumulative incidence of NGCD (17.8 vs. 10.6%; Gray's P=0.021) compared with the non‑IC group. Although a number of clinicopathological factors differed between the groups, including patient background, operative factors and tumor factors, the risk factors for NGCD identified in the multivariate analysis were older age, low prognostic nutritional index, low skeletal muscle index and Charlson comorbidity index ≥1, excluding IC incidents. The IC group exhibited more background factors contributing to NGCDs, suggesting a potential increase in NGCD regardless of IC incidence.
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Copy and paste a formatted citation
Spandidos Publications style
Nakashima C, Iida M, Nishiyama M, Watanabe Y, Shindo Y, Tokumitsu Y, Tomochika S, Nakagami Y, Takahashi H, Nagano H, Nagano H, et al: Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths. Oncol Lett 28: 562, 2024.
APA
Nakashima, C., Iida, M., Nishiyama, M., Watanabe, Y., Shindo, Y., Tokumitsu, Y. ... Nagano, H. (2024). Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths. Oncology Letters, 28, 562. https://doi.org/10.3892/ol.2024.14695
MLA
Nakashima, C., Iida, M., Nishiyama, M., Watanabe, Y., Shindo, Y., Tokumitsu, Y., Tomochika, S., Nakagami, Y., Takahashi, H., Nagano, H."Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths". Oncology Letters 28.6 (2024): 562.
Chicago
Nakashima, C., Iida, M., Nishiyama, M., Watanabe, Y., Shindo, Y., Tokumitsu, Y., Tomochika, S., Nakagami, Y., Takahashi, H., Nagano, H."Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths". Oncology Letters 28, no. 6 (2024): 562. https://doi.org/10.3892/ol.2024.14695
Copy and paste a formatted citation
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Spandidos Publications style
Nakashima C, Iida M, Nishiyama M, Watanabe Y, Shindo Y, Tokumitsu Y, Tomochika S, Nakagami Y, Takahashi H, Nagano H, Nagano H, et al: Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths. Oncol Lett 28: 562, 2024.
APA
Nakashima, C., Iida, M., Nishiyama, M., Watanabe, Y., Shindo, Y., Tokumitsu, Y. ... Nagano, H. (2024). Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths. Oncology Letters, 28, 562. https://doi.org/10.3892/ol.2024.14695
MLA
Nakashima, C., Iida, M., Nishiyama, M., Watanabe, Y., Shindo, Y., Tokumitsu, Y., Tomochika, S., Nakagami, Y., Takahashi, H., Nagano, H."Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths". Oncology Letters 28.6 (2024): 562.
Chicago
Nakashima, C., Iida, M., Nishiyama, M., Watanabe, Y., Shindo, Y., Tokumitsu, Y., Tomochika, S., Nakagami, Y., Takahashi, H., Nagano, H."Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths". Oncology Letters 28, no. 6 (2024): 562. https://doi.org/10.3892/ol.2024.14695
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