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Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review)

  • Authors:
    • Zhao Guo
    • Haoyan Zhuang
    • Xuewen Shi
  • View Affiliations / Copyright

    Affiliations: First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250000, P.R. China, Department of Anorectal, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250000, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 563
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    Published online on: September 26, 2024
       https://doi.org/10.3892/ol.2024.14697
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Abstract

Colorectal cancer (CRC) is the third most common malignancy worldwide, and the second leading cause of cancer‑associated mortality. The incidence and mortality rates of CRC remain high, posing a significant threat to humans and overall quality of life. Current therapeutic strategies, such as surgery and chemotherapy, are limited due to disease recurrence, chemotherapeutic drug resistance and toxicity. Thus, research is focused on the development of novel treatment approaches. In 2012, ferroptosis was identified as a form of regulated cell death that is iron‑dependent and driven by lipid peroxidation. Notably, therapies targeting ferroptosis exhibit potential in the treatment of disease; however, their role in CRC treatment remains controversial. The present study aimed to systematically review the mechanisms and signaling pathways of ferroptosis in CRC, and the specific role within the tumor microenvironment. Moreover, the present study aimed to review the role of ferroptosis in drug resistance, offering novel perspectives for the diagnosis and treatment of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Guo Z, Zhuang H and Shi X: Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review). Oncol Lett 28: 563, 2024.
APA
Guo, Z., Zhuang, H., & Shi, X. (2024). Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review). Oncology Letters, 28, 563. https://doi.org/10.3892/ol.2024.14697
MLA
Guo, Z., Zhuang, H., Shi, X."Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review)". Oncology Letters 28.6 (2024): 563.
Chicago
Guo, Z., Zhuang, H., Shi, X."Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review)". Oncology Letters 28, no. 6 (2024): 563. https://doi.org/10.3892/ol.2024.14697
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Z, Zhuang H and Shi X: Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review). Oncol Lett 28: 563, 2024.
APA
Guo, Z., Zhuang, H., & Shi, X. (2024). Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review). Oncology Letters, 28, 563. https://doi.org/10.3892/ol.2024.14697
MLA
Guo, Z., Zhuang, H., Shi, X."Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review)". Oncology Letters 28.6 (2024): 563.
Chicago
Guo, Z., Zhuang, H., Shi, X."Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review)". Oncology Letters 28, no. 6 (2024): 563. https://doi.org/10.3892/ol.2024.14697
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