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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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December-2024 Volume 28 Issue 6

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Case Report Open Access

Furosemide‑induced eradication of myeloblasts via the inhibition of tumor necrosis factor‑α expression in a patient with acute biphenotypic leukemia: A case report

  • Authors:
    • Yu-Wei Chang
    • Wan-Ru Chao
    • Yen-Ting Lai
    • Frank Sheng Fan
  • View Affiliations / Copyright

    Affiliations: School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402306, Taiwan, R.O.C., Department of Pathology, Chung Shan Medical University Hospital, Taichung 402306, Taiwan, R.O.C., Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402306, Taiwan, R.O.C.
    Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 578
    |
    Published online on: October 1, 2024
       https://doi.org/10.3892/ol.2024.14711
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Abstract

The present study reports the potential of furosemide therapeutic activity in acute myeloid leukemia. A 26‑year‑old man with acute biphenotypic leukemia was treated with furosemide for suspected pulmonary edema, which was later deemed to be an infiltration of leukemia cells. Notably, the myeloblast population was rapidly eliminated during furosemide therapy. Bone marrow specimens biopsied at different time points were used for immunohistochemical analysis of the expression levels of tumor necrosis factor‑α (TNF‑α) and its two receptors, TNF‑α receptors 1 and 2. The expression of TNF‑α and its receptors in the bone marrow was markedly suppressed by furosemide, along with the elimination of the myeloblasts. Thus, it was hypothesized that the growth of myeloblasts in the patient depended on autocrine and/or paracrine TNF‑α stimulation, whereas furosemide disrupted this positive feedback loop. Therefore, furosemide is suggested as an effective therapeutic agent for acute myeloid leukemia, at least as an adjunct to standard chemotherapy and gene‑targeted therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Chang Y, Chao W, Lai Y and Fan FS: Furosemide‑induced eradication of myeloblasts via the inhibition of tumor necrosis factor‑α expression in a patient with acute biphenotypic leukemia: A case report. Oncol Lett 28: 578, 2024.
APA
Chang, Y., Chao, W., Lai, Y., & Fan, F.S. (2024). Furosemide‑induced eradication of myeloblasts via the inhibition of tumor necrosis factor‑α expression in a patient with acute biphenotypic leukemia: A case report. Oncology Letters, 28, 578. https://doi.org/10.3892/ol.2024.14711
MLA
Chang, Y., Chao, W., Lai, Y., Fan, F. S."Furosemide‑induced eradication of myeloblasts via the inhibition of tumor necrosis factor‑α expression in a patient with acute biphenotypic leukemia: A case report". Oncology Letters 28.6 (2024): 578.
Chicago
Chang, Y., Chao, W., Lai, Y., Fan, F. S."Furosemide‑induced eradication of myeloblasts via the inhibition of tumor necrosis factor‑α expression in a patient with acute biphenotypic leukemia: A case report". Oncology Letters 28, no. 6 (2024): 578. https://doi.org/10.3892/ol.2024.14711
Copy and paste a formatted citation
x
Spandidos Publications style
Chang Y, Chao W, Lai Y and Fan FS: Furosemide‑induced eradication of myeloblasts via the inhibition of tumor necrosis factor‑α expression in a patient with acute biphenotypic leukemia: A case report. Oncol Lett 28: 578, 2024.
APA
Chang, Y., Chao, W., Lai, Y., & Fan, F.S. (2024). Furosemide‑induced eradication of myeloblasts via the inhibition of tumor necrosis factor‑α expression in a patient with acute biphenotypic leukemia: A case report. Oncology Letters, 28, 578. https://doi.org/10.3892/ol.2024.14711
MLA
Chang, Y., Chao, W., Lai, Y., Fan, F. S."Furosemide‑induced eradication of myeloblasts via the inhibition of tumor necrosis factor‑α expression in a patient with acute biphenotypic leukemia: A case report". Oncology Letters 28.6 (2024): 578.
Chicago
Chang, Y., Chao, W., Lai, Y., Fan, F. S."Furosemide‑induced eradication of myeloblasts via the inhibition of tumor necrosis factor‑α expression in a patient with acute biphenotypic leukemia: A case report". Oncology Letters 28, no. 6 (2024): 578. https://doi.org/10.3892/ol.2024.14711
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