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α‑Fetoprotein‑positive hepatoid adenocarcinoma of the stomach and a new classification: A case report 

  • Authors:
    • Zhen-Yu Ye
    • Chuan-Hai Xu
    • Wang Chen
    • Zhong-Ming Shao
    • Xue Zhao
    • Jin-Ling Tang
    • Xiang-Su Li
    • Xin Wang
    • Chao-Nan Wang
    • Qing-Qing Yang
    • Yang Huang
    • Xue-Yi Xiao
    • Xu-Dong Wu
    • Qi-Biao Wu
  • View Affiliations / Copyright

    Affiliations: Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa 999078, Macau SAR, P.R. China, Department of Pathology, Yancheng No. 1 People's Hospital, Yancheng, Jiangsu 224005, P.R. China, Department of Medical Imaging, Yancheng No. 1 People's Hospital, Yancheng, Jiangsu 224005, P.R. China, Department of General Medicine, Yancheng No. 1 People's Hospital, Yancheng, Jiangsu 224005, P.R. China, Gastrointestinal Endoscopy Center, Yancheng No. 1 People's Hospital, Yancheng, Jiangsu 224005, P.R. China, Department of Gastroenterology, Yancheng No. 1 People's Hospital, Yancheng, Jiangsu 224005, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 586
    |
    Published online on: October 3, 2024
       https://doi.org/10.3892/ol.2024.14717
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Abstract

α‑Fetoprotein (AFP)‑producing gastric carcinoma (AFPGC) is a rare subtype of gastric cancer (GC) with controversial classification methods. Hepatoid adenocarcinoma of the stomach (HAS) is another rare subtype of GC. Its definition intersects with that of AFPGC, but it is much rarer. The present report describes the case of an elderly patient with GC and AFPGC and HAS features in a serum test and pathology, respectively, and proposes a new classification of GC subtypes based on histological and AFP‑producing features. A 75‑year‑old woman presented with a history of polydipsia and polyuria for over a decade and dizziness for 1 day. Serum AFP levels gradually elevated from 183.70 to 397.70 ng/ml in 1 month after the patient's first clinic visit. Subsequent pathological findings from endoscopic biopsy samples confirmed a hepatoid focus with positive immunohistochemical staining for AFP. The patient underwent a laparoscopic‑assisted radical total gastrectomy and esophagojejunal Roux‑en‑Y anastomosis, and the serum AFP levels decreased to the normal range after the surgery. The present case indicates the diagnostic value of both the serum AFP level and pathological examinations in the diagnosis of AFPGC and HAS, and also highlights the contemporary circumstances of the vague classification based on different criteria for these two subtypes. Furthermore, the present report proposes a new classification considering both histological and AFP‑producing features (using both serum biomarkers and immunohistochemistry tests) to cover all cases encompassed by AFPGC and HAS under all definition methods. This new method would give more precise diagnoses and add value to the subsequent treatment decision‑making.
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Ye Z, Xu C, Chen W, Shao Z, Zhao X, Tang J, Li X, Wang X, Wang C, Yang Q, Yang Q, et al: α‑Fetoprotein‑positive hepatoid adenocarcinoma of the stomach and a new classification: A case report . Oncol Lett 28: 586, 2024.
APA
Ye, Z., Xu, C., Chen, W., Shao, Z., Zhao, X., Tang, J. ... Wu, Q. (2024). α‑Fetoprotein‑positive hepatoid adenocarcinoma of the stomach and a new classification: A case report . Oncology Letters, 28, 586. https://doi.org/10.3892/ol.2024.14717
MLA
Ye, Z., Xu, C., Chen, W., Shao, Z., Zhao, X., Tang, J., Li, X., Wang, X., Wang, C., Yang, Q., Huang, Y., Xiao, X., Wu, X., Wu, Q."α‑Fetoprotein‑positive hepatoid adenocarcinoma of the stomach and a new classification: A case report ". Oncology Letters 28.6 (2024): 586.
Chicago
Ye, Z., Xu, C., Chen, W., Shao, Z., Zhao, X., Tang, J., Li, X., Wang, X., Wang, C., Yang, Q., Huang, Y., Xiao, X., Wu, X., Wu, Q."α‑Fetoprotein‑positive hepatoid adenocarcinoma of the stomach and a new classification: A case report ". Oncology Letters 28, no. 6 (2024): 586. https://doi.org/10.3892/ol.2024.14717
Copy and paste a formatted citation
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Spandidos Publications style
Ye Z, Xu C, Chen W, Shao Z, Zhao X, Tang J, Li X, Wang X, Wang C, Yang Q, Yang Q, et al: α‑Fetoprotein‑positive hepatoid adenocarcinoma of the stomach and a new classification: A case report . Oncol Lett 28: 586, 2024.
APA
Ye, Z., Xu, C., Chen, W., Shao, Z., Zhao, X., Tang, J. ... Wu, Q. (2024). α‑Fetoprotein‑positive hepatoid adenocarcinoma of the stomach and a new classification: A case report . Oncology Letters, 28, 586. https://doi.org/10.3892/ol.2024.14717
MLA
Ye, Z., Xu, C., Chen, W., Shao, Z., Zhao, X., Tang, J., Li, X., Wang, X., Wang, C., Yang, Q., Huang, Y., Xiao, X., Wu, X., Wu, Q."α‑Fetoprotein‑positive hepatoid adenocarcinoma of the stomach and a new classification: A case report ". Oncology Letters 28.6 (2024): 586.
Chicago
Ye, Z., Xu, C., Chen, W., Shao, Z., Zhao, X., Tang, J., Li, X., Wang, X., Wang, C., Yang, Q., Huang, Y., Xiao, X., Wu, X., Wu, Q."α‑Fetoprotein‑positive hepatoid adenocarcinoma of the stomach and a new classification: A case report ". Oncology Letters 28, no. 6 (2024): 586. https://doi.org/10.3892/ol.2024.14717
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