Open Access

Steroidal saponins: Natural compounds with the potential to reverse tumor drug resistance (Review)

  • Authors:
    • Aiping Cui
    • Hai Liu
    • Xiaoxuan Liu
    • Minhong Zhang
    • Bang Xiao
    • Biao Wang
    • Jianqiong Yang
  • View Affiliations

  • Published online on: October 3, 2024     https://doi.org/10.3892/ol.2024.14719
  • Article Number: 585
  • Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Steroidal saponins are a type of natural product that have been widely used in Chinese herbal medicine, with a variety of pharmacological activities, such as antitumor, anti‑inflammatory and anti‑bacterial effects. Cancer has become a growing global health problem, and drug therapy is currently the most important clinical antitumor treatment. However, drug resistance is a major obstacle to the effectiveness of chemotherapy, resulting in >90% of deaths of patients with cancer receiving conventional chemotherapy. It has been found that steroidal saponins may exert an effect on the reversal of drug resistance in tumor cells by regulating apoptosis, autophagy, epithelial‑mesenchymal transition and drug efflux through multiple related signaling pathways. The present study reviews the role and mechanism of steroidal saponins in the treatment of tumor drug resistance, aiming to provide a scientific basis and research ideas for the future development and clinical application of natural steroidal saponins.
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December-2024
Volume 28 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Cui A, Liu H, Liu X, Zhang M, Xiao B, Wang B and Yang J: Steroidal saponins: Natural compounds with the potential to reverse tumor drug resistance (Review). Oncol Lett 28: 585, 2024.
APA
Cui, A., Liu, H., Liu, X., Zhang, M., Xiao, B., Wang, B., & Yang, J. (2024). Steroidal saponins: Natural compounds with the potential to reverse tumor drug resistance (Review). Oncology Letters, 28, 585. https://doi.org/10.3892/ol.2024.14719
MLA
Cui, A., Liu, H., Liu, X., Zhang, M., Xiao, B., Wang, B., Yang, J."Steroidal saponins: Natural compounds with the potential to reverse tumor drug resistance (Review)". Oncology Letters 28.6 (2024): 585.
Chicago
Cui, A., Liu, H., Liu, X., Zhang, M., Xiao, B., Wang, B., Yang, J."Steroidal saponins: Natural compounds with the potential to reverse tumor drug resistance (Review)". Oncology Letters 28, no. 6 (2024): 585. https://doi.org/10.3892/ol.2024.14719