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Review Open Access

Role of ENPP1 in cancer pathogenesis: Mechanisms and clinical implications (Review)

  • Authors:
    • Lujie Zhao
    • Yu Zhang
    • Yahui Tian
    • Xin Ding
    • Runling Lin
    • Lin Xiao
    • Fujun Peng
    • Kai Zhang
    • Zhongfa Yang
  • View Affiliations / Copyright

    Affiliations: School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong 261021, P.R. China, School of Clinical Medical Sciences, Shandong Second Medical University, Weifang, Shandong 261021, P.R. China, Genetic Testing Centre, Qingdao University Women's and Children's Hospital, Qingdao, Shandong 266000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 590
    |
    Published online on: October 3, 2024
       https://doi.org/10.3892/ol.2024.14722
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Abstract

Cancer is a significant societal, public health and economic challenge in the 21st century, and is the primary cause of death from disease globally. Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) serves a crucial role in several biochemical processes, including adenosine triphosphate hydrolysis, purine metabolism and regulation of signaling pathways. Specifically, ENPP1, a type II transmembrane glycoprotein and key member of the ENPP family, may be upregulated in tumor cells and implicated in the pathogenesis of multiple human cancers. The present review provides an overview of the structural, pathological and physiological roles of ENPP1 and discusses the potential mechanisms of ENPP1 in the development of cancers such as breast, colon, gallbladder, liver and lung cancers, and also summarizes the four major signaling pathways in tumors. Furthermore, the present review demonstrates that ENPP1 serves a crucial role in cell migration, proliferation and invasion, and that corresponding inhibitors have been developed and associated with clinical characterization.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao L, Zhang Y, Tian Y, Ding X, Lin R, Xiao L, Peng F, Zhang K and Yang Z: Role of ENPP1 in cancer pathogenesis: Mechanisms and clinical implications (Review). Oncol Lett 28: 590, 2024.
APA
Zhao, L., Zhang, Y., Tian, Y., Ding, X., Lin, R., Xiao, L. ... Yang, Z. (2024). Role of ENPP1 in cancer pathogenesis: Mechanisms and clinical implications (Review). Oncology Letters, 28, 590. https://doi.org/10.3892/ol.2024.14722
MLA
Zhao, L., Zhang, Y., Tian, Y., Ding, X., Lin, R., Xiao, L., Peng, F., Zhang, K., Yang, Z."Role of ENPP1 in cancer pathogenesis: Mechanisms and clinical implications (Review)". Oncology Letters 28.6 (2024): 590.
Chicago
Zhao, L., Zhang, Y., Tian, Y., Ding, X., Lin, R., Xiao, L., Peng, F., Zhang, K., Yang, Z."Role of ENPP1 in cancer pathogenesis: Mechanisms and clinical implications (Review)". Oncology Letters 28, no. 6 (2024): 590. https://doi.org/10.3892/ol.2024.14722
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L, Zhang Y, Tian Y, Ding X, Lin R, Xiao L, Peng F, Zhang K and Yang Z: Role of ENPP1 in cancer pathogenesis: Mechanisms and clinical implications (Review). Oncol Lett 28: 590, 2024.
APA
Zhao, L., Zhang, Y., Tian, Y., Ding, X., Lin, R., Xiao, L. ... Yang, Z. (2024). Role of ENPP1 in cancer pathogenesis: Mechanisms and clinical implications (Review). Oncology Letters, 28, 590. https://doi.org/10.3892/ol.2024.14722
MLA
Zhao, L., Zhang, Y., Tian, Y., Ding, X., Lin, R., Xiao, L., Peng, F., Zhang, K., Yang, Z."Role of ENPP1 in cancer pathogenesis: Mechanisms and clinical implications (Review)". Oncology Letters 28.6 (2024): 590.
Chicago
Zhao, L., Zhang, Y., Tian, Y., Ding, X., Lin, R., Xiao, L., Peng, F., Zhang, K., Yang, Z."Role of ENPP1 in cancer pathogenesis: Mechanisms and clinical implications (Review)". Oncology Letters 28, no. 6 (2024): 590. https://doi.org/10.3892/ol.2024.14722
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