Open Access

Roles of deubiquitinases in urologic cancers (Review)

  • Authors:
    • Liangpei Wu
    • Jiahui Wang
    • Lin Chai
    • Jun Chen
    • Xiaofeng Jin
  • View Affiliations

  • Published online on: October 14, 2024     https://doi.org/10.3892/ol.2024.14743
  • Article Number: 609
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human health is endangered by the occurrence and progression of urological cancers, including renal cell carcinoma, prostate cancer and bladder cancer, which are usually associated with the activation of oncogenic factors and inhibition of cancer suppressors. The primary mechanism for protein breakdown in cells is the ubiquitin‑proteasome system, whilst deubiquitinases contribute to the reversal of this process. However, both are important for protein homeostasis. Deubiquitination may also be involved in the control of the cell cycle, proliferation and apoptosis, and dysregulated deubiquitination is associated with the malignant transformation, invasion and metastasis of urologic malignancies. Therefore, a comprehensive summary of the mechanisms underlying deubiquitination in urological cancers may provide novel strategies and insights for diagnosis and treatment. The present review aimed to methodically clarify the role of deubiquitinating enzymes in urinary system cancers as well as their prospective application prospects for clinical treatment.

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December-2024
Volume 28 Issue 6

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Copy and paste a formatted citation
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Spandidos Publications style
Wu L, Wang J, Chai L, Chen J and Jin X: Roles of deubiquitinases in urologic cancers (Review). Oncol Lett 28: 609, 2024.
APA
Wu, L., Wang, J., Chai, L., Chen, J., & Jin, X. (2024). Roles of deubiquitinases in urologic cancers (Review). Oncology Letters, 28, 609. https://doi.org/10.3892/ol.2024.14743
MLA
Wu, L., Wang, J., Chai, L., Chen, J., Jin, X."Roles of deubiquitinases in urologic cancers (Review)". Oncology Letters 28.6 (2024): 609.
Chicago
Wu, L., Wang, J., Chai, L., Chen, J., Jin, X."Roles of deubiquitinases in urologic cancers (Review)". Oncology Letters 28, no. 6 (2024): 609. https://doi.org/10.3892/ol.2024.14743