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Efficacy and safety of anlotinib combined with S‑1 as a third‑ or later‑line treatment for advanced non‑small cell lung cancer in China: A systematic review and meta‑analysis

  • Authors:
    • Haonan Xu
    • Yuwen Liang
    • Wenqiang Tang
    • Xiongxin Yang
    • Xiaobo Du
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Department of Oncology, National Health Commission Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Mianyang, Sichuan 621000, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 613
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    Published online on: October 14, 2024
       https://doi.org/10.3892/ol.2024.14746
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Abstract

Anlotinib is presently used as a third‑line treatment for non‑small cell lung cancer. However, it is not yet reported whether combining anlotinib with S‑1 as a third‑ or later‑line treatment offers superior outcomes compared with anlotinib alone. The present meta‑analysis aimed to address this question by systematically searching the PubMed, Embase, Web of Science, Cochrane Library, CMB and China National Knowledge Infrastructure databases for eligible studies published from the establishment of the database to January 10, 2024. Primary outcomes of interest included progression‑free survival (PFS), overall survival (OS), objective response rate (ORR), disease control rate (DCR) and the incidence of adverse effects, which were presented as hazard ratios and 95% CIs. The present analysis included 5 retrospective studies with a total of 317 patients and compared the outcomes of patients treated with a combination of anlotinib and S‑1 (experimental group) compared with anlotinib alone (control group). The combination treatment significantly improved PFS, OS, ORR and DCR in the experimental group compared with the control group. Bone marrow suppression and fatigue were significantly higher in the experimental group compared with the control group. However, incidences of hypertension, proteinuria, gastrointestinal adverse reactions, hepatic and renal insufficiency and functional hand‑foot syndrome were higher in the control group compared with the experimental group, but there was no statistical significance. In summary, combining anlotinib with S‑1 may be more effective compared with anlotinib alone for treating advanced non‑small cell lung cancer. Despite the higher incidence of adverse reactions with the combination therapy, these reactions could be considered manageable and controllable.
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Copy and paste a formatted citation
Spandidos Publications style
Xu H, Liang Y, Tang W, Yang X and Du X: Efficacy and safety of anlotinib combined with S‑1 as a third‑ or later‑line treatment for advanced non‑small cell lung cancer in China: A systematic review and meta‑analysis. Oncol Lett 28: 613, 2024.
APA
Xu, H., Liang, Y., Tang, W., Yang, X., & Du, X. (2024). Efficacy and safety of anlotinib combined with S‑1 as a third‑ or later‑line treatment for advanced non‑small cell lung cancer in China: A systematic review and meta‑analysis. Oncology Letters, 28, 613. https://doi.org/10.3892/ol.2024.14746
MLA
Xu, H., Liang, Y., Tang, W., Yang, X., Du, X."Efficacy and safety of anlotinib combined with S‑1 as a third‑ or later‑line treatment for advanced non‑small cell lung cancer in China: A systematic review and meta‑analysis". Oncology Letters 28.6 (2024): 613.
Chicago
Xu, H., Liang, Y., Tang, W., Yang, X., Du, X."Efficacy and safety of anlotinib combined with S‑1 as a third‑ or later‑line treatment for advanced non‑small cell lung cancer in China: A systematic review and meta‑analysis". Oncology Letters 28, no. 6 (2024): 613. https://doi.org/10.3892/ol.2024.14746
Copy and paste a formatted citation
x
Spandidos Publications style
Xu H, Liang Y, Tang W, Yang X and Du X: Efficacy and safety of anlotinib combined with S‑1 as a third‑ or later‑line treatment for advanced non‑small cell lung cancer in China: A systematic review and meta‑analysis. Oncol Lett 28: 613, 2024.
APA
Xu, H., Liang, Y., Tang, W., Yang, X., & Du, X. (2024). Efficacy and safety of anlotinib combined with S‑1 as a third‑ or later‑line treatment for advanced non‑small cell lung cancer in China: A systematic review and meta‑analysis. Oncology Letters, 28, 613. https://doi.org/10.3892/ol.2024.14746
MLA
Xu, H., Liang, Y., Tang, W., Yang, X., Du, X."Efficacy and safety of anlotinib combined with S‑1 as a third‑ or later‑line treatment for advanced non‑small cell lung cancer in China: A systematic review and meta‑analysis". Oncology Letters 28.6 (2024): 613.
Chicago
Xu, H., Liang, Y., Tang, W., Yang, X., Du, X."Efficacy and safety of anlotinib combined with S‑1 as a third‑ or later‑line treatment for advanced non‑small cell lung cancer in China: A systematic review and meta‑analysis". Oncology Letters 28, no. 6 (2024): 613. https://doi.org/10.3892/ol.2024.14746
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