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Review Open Access

Role of disulfide death in cancer (Review)

  • Authors:
    • Xue Li
    • Danxia Zhu
  • View Affiliations / Copyright

    Affiliations: Oncology Department, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 55
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    Published online on: November 12, 2024
       https://doi.org/10.3892/ol.2024.14801
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Abstract

The research field of regulated cell death is growing extensively. Following the recognition of ferroptosis, other unique and distinct forms of regulated cell death, including cuproptosis and disulfide death, have been identified. Disulfide death occurs due to the abnormal accumulation of disulfides within cells in environments lacking glucose, leading to contraction of the actin cytoskeleton, which ultimately triggers various signaling pathways and cell death. The induction of disulfide death in the treatment of cancer may exhibit significant therapeutic potential. Therefore, in the present review, a comprehensive and critical analysis of the current understanding of the molecular mechanisms and regulatory networks of disulfide death is presented. In addition, the potential physiological functions of disulfide death in tumor suppression and immune surveillance as well as its pathological roles and therapeutic potential are described. The core focus areas for future research into this form of cell death are also explored. Given the current lack of extensive clinical findings and well‑defined key concepts, these may be regarded as pivotal points of interest in future studies.
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Copy and paste a formatted citation
Spandidos Publications style
Li X and Zhu D: Role of disulfide death in cancer (Review). Oncol Lett 29: 55, 2025.
APA
Li, X., & Zhu, D. (2025). Role of disulfide death in cancer (Review). Oncology Letters, 29, 55. https://doi.org/10.3892/ol.2024.14801
MLA
Li, X., Zhu, D."Role of disulfide death in cancer (Review)". Oncology Letters 29.1 (2025): 55.
Chicago
Li, X., Zhu, D."Role of disulfide death in cancer (Review)". Oncology Letters 29, no. 1 (2025): 55. https://doi.org/10.3892/ol.2024.14801
Copy and paste a formatted citation
x
Spandidos Publications style
Li X and Zhu D: Role of disulfide death in cancer (Review). Oncol Lett 29: 55, 2025.
APA
Li, X., & Zhu, D. (2025). Role of disulfide death in cancer (Review). Oncology Letters, 29, 55. https://doi.org/10.3892/ol.2024.14801
MLA
Li, X., Zhu, D."Role of disulfide death in cancer (Review)". Oncology Letters 29.1 (2025): 55.
Chicago
Li, X., Zhu, D."Role of disulfide death in cancer (Review)". Oncology Letters 29, no. 1 (2025): 55. https://doi.org/10.3892/ol.2024.14801
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