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Case Report Open Access

Primary breast myeloid sarcoma: A case report and literature review

  • Authors:
    • Zhiying Zhang
    • Yibo Chen
    • Rui Zhang
    • Ming Liu
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid Breast Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 58
    |
    Published online on: November 15, 2024
       https://doi.org/10.3892/ol.2024.14804
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Abstract

Myeloid sarcoma (MS) is a rare extramedullary tumor originating from immature bone marrow cells. MS of the breast is an extremely uncommon disease with non‑specific clinical and radiological features. The present case report describes a distinctive case of MS of the breast, which posed diagnostic challenges due to the absence of typical imaging characteristics at the time of presentation. The patient was a 58‑year‑old woman who presented with a breast mass. Further examination and testing confirmed the diagnosis of MS in the right breast, with metastases to the right iliac, pubic and ischial regions. Immunohistochemical analysis identified metastatic tumors distinguished by the expression of a number of markers, including Ki‑67, myeloperoxidase and cluster of differentiation 43. The patient underwent six cycles of chemotherapy with a regimen comprising etoposide, methylprednisolone, cytarabine and cisplatin, and 28 cycles (56 cGy each) of consolidation radiotherapy. Extensive examination and long‑term follow‑up revealed no further tumor recurrence or metastasis. Myeloid sarcomas of the breast typically manifest as palpable masses requiring diagnostic imaging. However, due to the rarity of MS of the breast without any signs of leukemia, its diagnosis and treatment are challenging. The present case report highlights the importance of maintaining high clinical, radiological and pathological standards when diagnosing this disease. Additionally, a comprehensive review of the literature on breast MS is provided. This highlights the necessity for clinicians to consider this rare diagnosis in patients presenting with a breast mass, to facilitate the appropriate treatment and prevent unnecessary procedures such as mastectomies.
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1 

Goyal G, Bartley AC, Patnaik MM, Litzow MR, Al-Kali A and Go RS: Clinical features and outcomes of extramedullary myeloid sarcoma in the United States: Analysis using a national data set. Blood Cancer J. 7:e5922017. View Article : Google Scholar : PubMed/NCBI

2 

Fitoz S, Atasoy C, Yavuz K, Gozdasoglu S, Erden I and Akyar S: Granulocytic sarcoma. Cranial and breast involvement. Clin Imaging. 26:166–169. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Ngu IW, Sinclair EC, Greenaway S and Greenberg ML: Unusual presentation of granulocytic sarcoma in the breast: A case report and review of the literature. Diagn Cytopathol. 24:53–57. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Cunningham I: A clinical review of breast involvement in acute leukemia. Leuk Lymphoma. 47:2517–2526. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Yamauchi K and Yasuda M: Comparison in treatments of nonleukemic granulocytic sarcoma: Report of two cases and a review of 72 cases in the literature. Cancer. 94:1739–1746. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Kewalramani T, Zelenetz AD, Nimer SD, Portlock C, Straus D, Noy A, O'Connor O, Filippa DA, Teruya-Feldstein J, Gencarelli A, et al: Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma. Blood. 103:3684–3688. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Miyazaki C, Shiozawa M, Koike R, Ogihara K, Sasaki Y, Shiba S, Nishida S, Sakuragi M, Mizunuma H, Fujita T, et al: Neoadjuvant chemotherapy for primary sarcoma of the breast: A case report. J Med Case Rep. 13:2892019. View Article : Google Scholar : PubMed/NCBI

8 

Wu L, Li X, Su J, Chang C, He Q, Zhang X, Xu L, Song L and Pu Q: Effect of low-dose cytarabine, homoharringtonine and granulocyte colony-stimulating factor priming regimen on patients with advanced myelodysplastic syndrome or acute myeloid leukemia transformed from myelodysplastic syndrome. Leuk Lymphoma. 50:1461–1467. 2009. View Article : Google Scholar : PubMed/NCBI

9 

National Comprehensive Cancer Network, . NCCN clinical practice guidelines in oncology: Antiemesis. Version 3.2024. http://www.nccn.org/professionals/physician_gls/PDF/antiemesis.pdf

10 

Grantham JT, Howell DM, Bacaj PJ, Coad JE and Vos JA: Myeloid sarcoma of the bladder in the setting of refractory anemia with excess blasts-2 (RAEB-2). W V Med J. 111:34–36. 2015.PubMed/NCBI

11 

Nicosia L, Latronico A, Farina M, Bozzini AC, Baratella P, Galimberti VE, Fiori S, Montesano M and Cassano E: Myeloid sarcoma of the breast: A pathology that should not be forgotten. Ecancermedicalscience. 14:11602020. View Article : Google Scholar : PubMed/NCBI

12 

Thachil J, Richards RM and Copeland G: Granulocytic sarcoma-a rare presentation of a breast lump. Ann R Coll Surg Engl. 89:W7–W9. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Yu T, Xu G, Xu X, Yang J and Ding L: Myeloid sarcoma derived from the gastrointestinal tract: A case report and review of the literature. Oncol Lett. 11:4155–4159. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Viadana E, Bross ID and Pickren JW: An autopsy study of the metastatic patterns of human leukemias. Oncology. 35:87–96. 1978. View Article : Google Scholar : PubMed/NCBI

15 

Naamo S, Naamo S, Sarker S, Vasconez M and Froicu M: Breast manifestation of extramedullary myeloid sarcoma: A case report. Radiol Case Rep. 17:4660–4665. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Amiraian D, McDonough M and Geiger X: Bilateral myeloid sarcoma of the breast: A case report with radiological and pathological correlation. Cureus. 14:e247312022.PubMed/NCBI

17 

Ding Y, Xi D, Chen Y and Gu W: Myeloid sarcoma of the breast as a first manifestation of acute myeloid leukemia: A case report. Asian J Surg. 45:1622–1623. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Huang C, Fei S, Yao J, Chen P, Luo J, Wang Y, Li J and Wang W: Breast myeloid sarcoma presenting as a palpable breast lump after allogeneic stem cell transplantation for acute myelomonocytic leukemia: A rare case report. World J Surg Oncol. 19:2892021. View Article : Google Scholar : PubMed/NCBI

19 

Varol E, Kiraz U, Guler SA, Vural Ç, Gülbaş Z and Utkan NZ: Breast recurrence of acute myeloid leukemia after bone marrow transplantation: A case report about myeloid sarcoma of the breast. Eur J Breast Health. 17:292–295. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Kim SJ and Kim WG: Sonographic features of a myeloid sarcoma of the breast as a relapse of acute myeloid leukemia after stem-cell transplantation: A case report. Am J Case Rep. 20:612–619. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Wu HY, Liu L, Gu L and Luo YH: Clinical characteristics and management of primary granulocytic sarcoma of the breast: A case report. Medicine (Baltimore). 98:e166482019. View Article : Google Scholar : PubMed/NCBI

22 

Gomaa W and Ghanim A, Emam E, Bayoumi K and Ghanim A: Primary myeloid sarcoma of the breast: A case report and review of literature. J Microsc Ultrastruct. 6:212–214. 2018.PubMed/NCBI

23 

Uchida E, Watanabe K, Oshikawa G, Sakashita C, Kurosu T, Fukuda T, Arai A, Murakami N, Miura O and Yamamoto M: Refractory primary myeloid sarcoma of the breast with MLL-AF9 rearrangement. Rinsho Ketsueki. 57:47–51. 2016.PubMed/NCBI

24 

Stewart RL, Dell CM and Samayoa L: Myeloid sarcoma of the breast misdiagnosed as poorly differentiated mammary carcinoma with lobular features. Breast J. 21:192–193. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Nalwa A, Nath D, Suri V, Jamaluddin MA and Srivastava A: Myeloid sarcoma of the breast in an aleukemic patient: A rare entity in an uncommon location. Malays J Pathol. 37:63–66. 2015.PubMed/NCBI

26 

Gündüz E, Akay MO, Karagülle M and Ak IS: isolated granulocytic sarcoma of the breast after allogeneic stem cell transplantation: A rare involvement also detected by 18FDG-PET/CT. Turk J Haematol. 31:88–91. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Fu J and Luo J: Granulocytic sarcoma of the breast in acute myeloid leukemia: Two case reports. Oncol Lett. 7:145–147. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Avni B and Koren-Michowitz M: Myeloid sarcoma: Current approach and therapeutic options. Ther Adv Hematol. 2:309–316. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Li JM, Liu WP, Zhang MH, Wei X, Gu JM, Han AJ, Wu WQ and Chen XY: Clinicopathologic and immunophenotypic analysis of myeloid sarcoma. Zhonghua Bing Li Xue Za Zhi. 35:606–611, (In Chinese). PubMed/NCBI

30 

Pileri SA, Ascani S, Cox MC, Campidelli C, Bacci F, Piccioli M, Piccaluga PP, Agostinelli C, Asioli S, Novero D, et al: Myeloid sarcoma: Clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 21:340–350. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Estey EH: Acute myeloid leukemia: 2019 update on risk-stratification and management. Am J Hematol. 93:1267–1291. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Traweek ST, Arber DA, Rappaport H and Brynes R: Extramedullary myeloid cell tumors. An immunohistochemical and morphologic study of 28 cases. Am J Surg Pathol. 17:1011–1019. 1993. View Article : Google Scholar : PubMed/NCBI

33 

Audouin J, Comperat E, Le Tourneau A, Camilleri-Broët S, Adida C, Molina T and Diebold J: Myeloid sarcoma: Clinical and morphologic criteria useful for diagnosis. Int J Surg Pathol. 11:271–282. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Mourad W, Kfoury H and Al Husseini H: The value of CD34, myeloperoxidase and chloroacetate esterase (Leder) stain in the diagnosis of granulocytic sarcoma. Ann Saudi Med. 21:287–291. 2001. View Article : Google Scholar : PubMed/NCBI

35 

He J, Zhu L, Ye X, Li L, Zhu J, Zhang J, Xie W, Shi J, Zheng W, Wei G, et al: Clinical characteristics and prognosis of nonleukemic myeloid sarcoma. Am J Med Sci. 347:434–438. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Florou D, Katsara M, Feehan J, Dardiotis E and Apostolopoulos V: Anti-CD20 agents for multiple sclerosis: Spotlight on ocrelizumab and ofatumumab. Brain Sci. 10:7582020. View Article : Google Scholar : PubMed/NCBI

37 

Huang XE, Li YJ and Zhou XD: Granulocytic sarcoma of the breast: A case report. Oncol Lett. 10:2447–2449. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Widhalm G, Dietrich W, Müllauer L, Streubel B, Rabitsch W, Kotter MR, Knosp E and Roessler K: Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. J Neurosurg. 105:916–919. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Tsimberidou AM, Kantarjian HM, Wen S, Keating MJ, O'Brien S, Brandt M, Pierce S, Freireich EJ, Medeiros LJ and Estey E: Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. Cancer. 113:1370–1378. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Védy D, Muehlematter D, Rausch T, Stalder M, Jotterand M and Spertini O: Acute myeloid leukemia with myeloid sarcoma and eosinophilia: Prolonged remission and molecular response to imatinib. J Clin Oncol. 28:e33–e35. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Spak DA, Plaxco JS, Santiago L, Dryden MJ and Dogan BE: BI-RADS((R)) fifth edition: A summary of changes. Diagn Interv Imaging. 98:179–190. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Chen Y, Zhang R and Liu M: Primary breast myeloid sarcoma: A case report and literature review. Oncol Lett 29: 58, 2025.
APA
Zhang, Z., Chen, Y., Zhang, R., & Liu, M. (2025). Primary breast myeloid sarcoma: A case report and literature review. Oncology Letters, 29, 58. https://doi.org/10.3892/ol.2024.14804
MLA
Zhang, Z., Chen, Y., Zhang, R., Liu, M."Primary breast myeloid sarcoma: A case report and literature review". Oncology Letters 29.1 (2025): 58.
Chicago
Zhang, Z., Chen, Y., Zhang, R., Liu, M."Primary breast myeloid sarcoma: A case report and literature review". Oncology Letters 29, no. 1 (2025): 58. https://doi.org/10.3892/ol.2024.14804
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Chen Y, Zhang R and Liu M: Primary breast myeloid sarcoma: A case report and literature review. Oncol Lett 29: 58, 2025.
APA
Zhang, Z., Chen, Y., Zhang, R., & Liu, M. (2025). Primary breast myeloid sarcoma: A case report and literature review. Oncology Letters, 29, 58. https://doi.org/10.3892/ol.2024.14804
MLA
Zhang, Z., Chen, Y., Zhang, R., Liu, M."Primary breast myeloid sarcoma: A case report and literature review". Oncology Letters 29.1 (2025): 58.
Chicago
Zhang, Z., Chen, Y., Zhang, R., Liu, M."Primary breast myeloid sarcoma: A case report and literature review". Oncology Letters 29, no. 1 (2025): 58. https://doi.org/10.3892/ol.2024.14804
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