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Case Report Open Access

Type III pleuropulmonary blastoma: A case report

  • Authors:
    • Shuai Luo
    • Xiaoxue Tian
    • Ting Xu
    • Jinjing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 117
    |
    Published online on: January 3, 2025
       https://doi.org/10.3892/ol.2025.14864
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Abstract

Pleuropulmonary blastoma (PPB) is an uncommon malignant neoplasm occurring in infants. The disease is intimately linked to mutations in the Dcr‑1 homolog and ribonuclease type III (DICER1) genes. Imaging techniques are crucial for diagnosing PPB, yet distinguishing PPB from other pulmonary masses proves challenging. Early detection of PPB is problematic, and it is often diagnosed at an advanced pathological stage with a poor prognosis. The present report discusses a PPB case and evaluates its clinical manifestations, imaging characteristics, pathological features and molecular genetic changes. The patient was a 3‑year‑old female who presented to Affiliated Hospital of Zunyi Medical University (Zunyi, China) with an unexplained cough. Chest computed tomography revealed a mass in the right thoracic cavity, which was identified as a neoplastic lesion and considered a potential PPB. Surgical intervention was performed. The postoperative pathological examination confirmed PPB (type III) with rhabdomyomatous and chondroid differentiation. After surgery, the patient was treated with regular chemotherapy and at follow‑up was doing well without recurrence. In conclusion, PPB represents a rare pathological diagnosis. The present report highlights the significance of noting clinical symptoms in infants, promptly performing pulmonary imaging and pathological examinations, and performing genetic testing when required. Furthermore, long‑term surveillance of families with DICER1 syndrome is vital for infants diagnosed with PPB.
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Copy and paste a formatted citation
Spandidos Publications style
Luo S, Tian X, Xu T and Wang J: Type III pleuropulmonary blastoma: A case report. Oncol Lett 29: 117, 2025.
APA
Luo, S., Tian, X., Xu, T., & Wang, J. (2025). Type III pleuropulmonary blastoma: A case report. Oncology Letters, 29, 117. https://doi.org/10.3892/ol.2025.14864
MLA
Luo, S., Tian, X., Xu, T., Wang, J."Type III pleuropulmonary blastoma: A case report". Oncology Letters 29.3 (2025): 117.
Chicago
Luo, S., Tian, X., Xu, T., Wang, J."Type III pleuropulmonary blastoma: A case report". Oncology Letters 29, no. 3 (2025): 117. https://doi.org/10.3892/ol.2025.14864
Copy and paste a formatted citation
x
Spandidos Publications style
Luo S, Tian X, Xu T and Wang J: Type III pleuropulmonary blastoma: A case report. Oncol Lett 29: 117, 2025.
APA
Luo, S., Tian, X., Xu, T., & Wang, J. (2025). Type III pleuropulmonary blastoma: A case report. Oncology Letters, 29, 117. https://doi.org/10.3892/ol.2025.14864
MLA
Luo, S., Tian, X., Xu, T., Wang, J."Type III pleuropulmonary blastoma: A case report". Oncology Letters 29.3 (2025): 117.
Chicago
Luo, S., Tian, X., Xu, T., Wang, J."Type III pleuropulmonary blastoma: A case report". Oncology Letters 29, no. 3 (2025): 117. https://doi.org/10.3892/ol.2025.14864
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