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Article Open Access

Efficacy evaluation of prophylactic cranial irradiation for limited stage small‑cell lung cancer in the magnetic resonance imaging era: A meta‑analysis

  • Authors:
    • Lihua Shao
    • Yumei Dong
    • Meiqiao Jiang
    • Haixia Song
    • Yuexiao Qi
    • Liyun Guo
    • Jinhui Tian
    • Shihong Wei
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, Sun Yat‑sen University Cancer Center Gansu Hospital, Lanzhou, Gansu 730050, P.R. China, School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730030, P.R. China, School of Public Health, Lanzhou University, Lanzhou, Gansu 730030, P.R. China
    Copyright: © Shao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 123
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    Published online on: January 7, 2025
       https://doi.org/10.3892/ol.2025.14870
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Abstract

The role of prophylactic cranial irradiation (PCI) in patients with limited‑stage small‑cell lung cancer (LS‑SCLC) remains controversial in the era of magnetic resonance imaging (MRI). The present study aimed to evaluate the effectiveness of PCI in the treatment of LS‑SCLC in the era of MRI. The PubMed, EMBASE and Cochrane Library databases were searched from the time of database creation until May 24, 2023, to identify clinical studies that evaluated the effectiveness of PCI in patients with LS‑SCLC in the MRI era. The references of the obtained studies were also reviewed to identify clinical studies that were not discovered in the initial search. All studies were screened in accordance with the inclusion criteria, and the data were extracted and subjected to meta‑analysis using STATA17.0. In total, 21 studies were included in the analysis. Notably, 10 studies only used brain MRI at baseline to confirm the absence of brain metastases (BMs; pre‑chemoradiotherapy MRI group), 7 studies used brain MRI prior to PCI to confirm the absence of BMs (pre‑PCI MRI group) and 4 studies used active surveillance in the form of brain MRI following PCI (MRI surveillance group). The results of the meta‑analysis demonstrated that for all included patients, PCI was associated with a significant improvement in overall survival time [OS; hazard ratio (HR), 0.61; confidence interval (CI), 0.53‑0.70] and progression‑free survival (HR, 0.69; CI, 0.61‑0.79), as well as a significant decrease in the rate of BM (HR, 0.59; CI, 0.50‑0.70). Subgroup analyses revealed that PCI remained effective in improving OS and reducing the rate of BM in patients with LS‑SCLC who did not have BMs confirmed via brain MRI performed at baseline or prior to PCI. However, in the MRI surveillance group, PCI failed to significantly improve the OS (HR, 0.65; CI, 0.41‑1.05), despite significantly reducing the BM rate (HR, 0.6; CI, 0.45‑0.8) of LS‑SCLC. Collectively, the results of the present study demonstrated that PCI remained effective in improving OS and reducing the rate of BM in patients with LS‑SCLC who had the absence of BM confirmed via brain MRI at baseline or prior to PCI. Additionally, in patients with LS‑SCLC who had undergone active surveillance using brain MRI following PCI, the incidence of BM was reduced, while the OS was not significantly improved. However, additional randomized controlled clinical studies are required to verify these findings.
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View References

1 

Govindan R, Page N, Morgensztern D, Read W, Tierney R, Vlahiotis A, Spitznagel EL and Piccirillo J: Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol. 24:4539–4544. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Manapov F, Käsmann L, Roengvoraphoj O, Dantes M, Schmidt-Hegemann NS, Belka C and Eze C: Prophylactic cranial irradiation in small-cell lung cancer: Update on patient selection, efficacy and outcomes. Lung Cancer (Auckl). 9:49–55. 2018.PubMed/NCBI

3 

Alexopoulos CG, Vaslamatzis M, Patilla E and Taranto L: Central nervous system involvement and the role of prophylactic cranial irradiation in small cell lung cancer. Oncologist. 2:153–159. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Arriagada R, Le Chevalier T, Borie F, Rivière A, Chomy P, Monnet I, Tardivon A, Viader F, Tarayre M and Benhamou S: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. J Natl Cancer Inst. 87:183–190. 1995. View Article : Google Scholar : PubMed/NCBI

5 

Elliott JA, Osterlind K, Hirsch FR and Hansen HH: Metastatic patterns in small-cell lung cancer: Correlation of autopsy findings with clinical parameters in 537 patients. J Clin Oncol. 5:246–254. 1987. View Article : Google Scholar : PubMed/NCBI

6 

Aupérin A, Arriagada R, Pignon JP, Le Péchoux C, Gregor A, Stephens RJ, Kristjansen PE, Johnson BE, Ueoka H, Wagner H and Aisner J: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic cranial irradiation overview collaborative group. N Engl J Med. 341:476–484. 1999. View Article : Google Scholar : PubMed/NCBI

7 

National Comprehensive Cancer Network, . Clinical practice guide-lines in oncology: small cell lung cancer (version 1). 2022.https://www.nccn.org/professionals/physician_gls/default.aspx#sclc

8 

Meert AP, Paesmans M, Berghmans T, Martin B, Mascaux C, Vallot F, Verdebout JM, Lafitte JJ and Sculier JP: Prophylactic cranial irradiation in small cell lung cancer: A systematic review of the literature with meta-analysis. BMC Cancer. 1:52001. View Article : Google Scholar : PubMed/NCBI

9 

Seute T, Leffers P, ten Velde GP and Twijnstra A: Detection of brain metastases from small cell lung cancer: Consequences of changing imaging techniques (CT versus MRI). Cancer. 112:1827–1834. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Chen Y, Wang Y, Ren F, Huang Z, Tan B, Zhao Z, Yu X, Dong P, Yu J and Meng X: Prophylactic cranial irradiation (PCI) versus active surveillance in patients with limited-stage small cell lung cancer: A retrospective, multicentre study. Respir Res. 23:2742022. View Article : Google Scholar : PubMed/NCBI

11 

Eze C, Roengvoraphoj O, Niyazi M, Hildebrandt G, Fietkau R, Belka C and Manapov F: Treatment response and prophylactic cranial irradiation are prognostic factors in a real-life limited-disease small-cell lung cancer patient cohort comprehensively staged with cranial magnetic resonance imaging. Clin Lung Cancer. 18:e243–e249. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Inoue Y, Tsujino K, Sulaiman NS, Marudai M, Kajihara A, Miyazaki S, Sekii S, Uezono H, Ota Y and Soejima T: Re-evaluation of prophylactic cranial irradiation in limited-stage small cell lung cancer: A propensity score matched analysis. J Radiat Res. 62:877–883. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Zhu H, Guo H, Shi F, Zhu K, Luo J, Liu X, Kong L and Yu J: Prophylactic cranial irradiation improved the overall survival of patients with surgically resected small cell lung cancer, but not for stage I disease. Lung Cancer. 86:334–338. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Li J, Ding C, Yang C, Wang S and Qiao X: Prophylactic cranial irradiation confers favourable prognosis for patients with limited-stage small cell lung cancer in the era of MRI: A propensity score-matched analysis. J Med Imaging Radiat Oncol. 65:778–785. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Mamesaya N, Wakuda K, Omae K, Miyawaki E, Kotake M, Fujiwara T, Kawamura T, Kobayashi H, Nakashima K, Omori S, et al: Efficacy of prophylactic cranial irradiation in patients with limited-disease small-cell lung cancer who were confirmed to have no brain metastasis via magnetic resonance imaging after initial chemoradiotherapy. Oncotarget. 9:17664–17674. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Ozawa Y, Omae M, Fujii M, Matsui T, Kato M, Sagisaka S, Asada K, Karayama M, Shirai T, Yasuda K, et al: Management of brain metastasis with magnetic resonance imaging and stereotactic irradiation attenuated benefits of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer. BMC Cancer. 15:5892015. View Article : Google Scholar : PubMed/NCBI

17 

Pan L, Fan X, Wang L, Wang Y, Li Y, Cui Y, Zheng H, Yi Q and Wu K: Prophylactic cranial irradiation for limited-stage small-cell lung cancer in the magnetic resonance imaging era. Cancer Med. 12:2484–2492. 2023. View Article : Google Scholar : PubMed/NCBI

18 

Qi C, Li W, Li H, Wen F, Zhou L, Sun X and Yu H: Benefits of prophylactic cranial irradiation in the MRI era for patients with limited stage small cell lung cancer. Front Oncol. 12:8334782022. View Article : Google Scholar : PubMed/NCBI

19 

Ghanta S, Keller A, Rodríguez-López JL, Patel A and Beriwal S: Utility of prophylactic cranial irradiation for limited stage small cell lung cancer in the modern era with magnetic resonance imaging surveillance. Clin Oncol (R Coll Radiol). 33:e323–e330. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Pezzi TA, Fang P, Gjyshi O, Feng L, Liu S, Komaki R and Lin SH: Rates of overall survival and intracranial control in the magnetic resonance imaging era for patients with limited-stage small cell lung cancer with and without prophylactic cranial irradiation. JAMA Netw Open. 3:e2019292020. View Article : Google Scholar : PubMed/NCBI

21 

Farooqi AS, Holliday EB, Allen PK, Wei X, Cox JD and Komaki R: Prophylactic cranial irradiation after definitive chemoradiotherapy for limited-stage small cell lung cancer: Do all patients benefit? Radiother Oncol. 122:307–312. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Sas-Korczyńska B, Łuczyńska E, Kamzol W and Sokołowski A: Analysis of risk factors for pulmonary complications in patients with limited-stage small cell lung cancer: A single-centre retrospective study. Strahlenther Onkol. 193:141–149. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Chen MY, Hu X, Xu YJ and Chen M: The impact of prophylactic cranial irradiation for post-operative patients with limited stage small cell lung cancer. Medicine (Baltimore). 97:e130292018. View Article : Google Scholar : PubMed/NCBI

24 

Kim TG, Pyo H, Ahn YC, Noh JM and Oh D: Role of prophylactic cranial irradiation for elderly patients with limited-disease small-cell lung cancer: Inverse probability of treatment weighting using propensity score. J Radiat Res. 60:630–638. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Lee TH, Chung JH, Wu HG, Kim S, Lee JH, Keam B, Kim JS, Kim KH, Kim BH and Kim HJ: Efficacy of prophylactic cranial irradiation according to the risk of extracranial recurrence in limited-stage small cell lung cancer. Cancer Res Treat. 55:875–884. 2023. View Article : Google Scholar : PubMed/NCBI

26 

Farris MK, Wheless WH, Hughes RT, Soike MH, Masters AH, Helis CA, Chan MD, Cramer CK, Ruiz J, Lycan T, et al: Limited-stage small cell lung cancer: Is prophylactic cranial irradiation necessary? Pract Radiat Oncol. 9:e599–e607. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Yin K, Song D, Zhang H, Cai F, Chen J and Dang J: Efficacy of surgery and prophylactic cranial irradiation in stage II and III small cell lung cancer. J Cancer. 9:3500–3506. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Held MK, Hansen O, Schytte T, Hansen KH, Bahij R, Nielsen M, Nielsen TB and Jeppesen SS: Outcomes of prophylactic cranial irradiation in patients with small cell lung cancer in the modern era of baseline magnetic resonance imaging of the brain. Acta Oncol. 61:185–192. 2022. View Article : Google Scholar : PubMed/NCBI

29 

Lim YJ, Song C and Kim HJ; Korean Association for Lung Cancer and Korea Central Cancer Registry, : survival impact of prophylactic cranial irradiation in small-cell lung cancer in the modern era of magnetic resonance imaging staging. Radiat Oncol. 17:262022. View Article : Google Scholar : PubMed/NCBI

30 

Jeong JU, Jeon W, Ahn SJ, Kim YC, Oh IJ, Park CK, Yoon MS, Song JY, Nam TK and Chung WK: Treatment time to the end of thoracic radiotherapy has more predictive power for survival than radiation dose intensity in patients with limited-stage small-cell lung cancer receiving concurrent chemoradiation of more than 45 Gy. Oncol Lett. 19:239–246. 2020.PubMed/NCBI

31 

Cook DA and Reed DA: Appraising the quality of medical education research methods: The medical education research study quality instrument and the newcastle-ottawa scale-education. Acad Med. 90:1067–1076. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Tierney JF, Stewart LA, Ghersi D, Burdett S and Sydes MR: Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 8:162007. View Article : Google Scholar : PubMed/NCBI

33 

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ and Welch VA: Cochrane handbook for systematic reviews of interventions version 6.5 (updated August 2024). Cochrane; 2024, Available from. www.training.cochrane.org/handbook

34 

Manapov F, Klautke G and Fietkau R: Prevalence of brain metastases immediately before prophylactic cranial irradiation in limited disease small cell lung cancer patients with complete remission to chemoradiotherapy: A single institution experience. J Thorac Oncol. 3:652–655. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Chi C, Wang C, Dong L, Li X and Xu L: Prophylactic cranial irradiation in limited-stage small cell lung cancer: A meta-analysis. J Coll Physicians Surg Pak. 34:461–467. 2024. View Article : Google Scholar : PubMed/NCBI

36 

Liu J, Shen B, Yang Y, Guo J, Ren W, Zhou Q, Mao J, Ye W and Wu D: Survival benefit of prophylactic cranial irradiation in limited-stage small-cell lung cancer in modern magnetic resonance imaging staging: A systematic review and meta-analysis. Acta Oncol. 62:305–314. 2023. View Article : Google Scholar : PubMed/NCBI

37 

Takahashi T, Yamanaka T, Seto T, Harada H, Nokihara H, Saka H, Nishio M, Kaneda H, Takayama K, Ishimoto O, et al: Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: A multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 18:663–671. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Levy A, Rusthoven CG, Brown PD, Le Péchoux C and Faivre-Finn C: Prophylactic cranial irradiation for patients with SCLC-A new perspective in the immunotherapy era. J Thorac Oncol. 15:S1556-0864-02446-8. 2024.

39 

Levy A, Berghmans T, Koller M, Fournier B, Mauer M, Andratschke N and Faivre-Finn C: PRIMALung (EORTC-1901): PRophylactic cerebral irradiation (PCI) or active brain MAgnetic resonance imaging (MRI) surveillance in small-cell lung cancer (SCLC) patients. Lung Cancer. 198:1079932024. View Article : Google Scholar : PubMed/NCBI

40 

S1827 (MAVERICK) Testing whether the use of brain scans alone instead of brain scans plus preventive brain radiation affects lifespan in patients with small cell lung cancer. https://clinicaltrials.gov/study/NCT04155034

41 

Ellis PM, Swaminath A and Pond GR: Patterns of relapse in small cell lung cancer: Competing risks of thoracic versus CNS relapse. Curr Oncol. 28:2778–2788. 2021. View Article : Google Scholar : PubMed/NCBI

42 

David RS, Ying C, Byoung CC, Laktionov KK, Fang J, Chen Y, Zenke Y, Lee KH, Wang Q, Navarro A, et al: ADRIATIC: Durvalumab (D) as consolidation treatment (tx) for patients (pts) with limited-stage small-cell lung cancer (LS-SCLC). ASCO; LBA5: 2024

43 

Welsh JW, Heymach JV, Guo C, Menon H, Klein K, Cushman TR, Verma V, Hess KR, Shroff G, Tang C, et al: Phase 1/2 Trial of Pembrolizumab and Concurrent Chemoradiation Therapy for Limited-Stage SCLC. J Thorac Oncol. 15:1919–1927. 2020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shao L, Dong Y, Jiang M, Song H, Qi Y, Guo L, Tian J and Wei S: Efficacy evaluation of prophylactic cranial irradiation for limited stage small‑cell lung cancer in the magnetic resonance imaging era: A meta‑analysis. Oncol Lett 29: 123, 2025.
APA
Shao, L., Dong, Y., Jiang, M., Song, H., Qi, Y., Guo, L. ... Wei, S. (2025). Efficacy evaluation of prophylactic cranial irradiation for limited stage small‑cell lung cancer in the magnetic resonance imaging era: A meta‑analysis. Oncology Letters, 29, 123. https://doi.org/10.3892/ol.2025.14870
MLA
Shao, L., Dong, Y., Jiang, M., Song, H., Qi, Y., Guo, L., Tian, J., Wei, S."Efficacy evaluation of prophylactic cranial irradiation for limited stage small‑cell lung cancer in the magnetic resonance imaging era: A meta‑analysis". Oncology Letters 29.3 (2025): 123.
Chicago
Shao, L., Dong, Y., Jiang, M., Song, H., Qi, Y., Guo, L., Tian, J., Wei, S."Efficacy evaluation of prophylactic cranial irradiation for limited stage small‑cell lung cancer in the magnetic resonance imaging era: A meta‑analysis". Oncology Letters 29, no. 3 (2025): 123. https://doi.org/10.3892/ol.2025.14870
Copy and paste a formatted citation
x
Spandidos Publications style
Shao L, Dong Y, Jiang M, Song H, Qi Y, Guo L, Tian J and Wei S: Efficacy evaluation of prophylactic cranial irradiation for limited stage small‑cell lung cancer in the magnetic resonance imaging era: A meta‑analysis. Oncol Lett 29: 123, 2025.
APA
Shao, L., Dong, Y., Jiang, M., Song, H., Qi, Y., Guo, L. ... Wei, S. (2025). Efficacy evaluation of prophylactic cranial irradiation for limited stage small‑cell lung cancer in the magnetic resonance imaging era: A meta‑analysis. Oncology Letters, 29, 123. https://doi.org/10.3892/ol.2025.14870
MLA
Shao, L., Dong, Y., Jiang, M., Song, H., Qi, Y., Guo, L., Tian, J., Wei, S."Efficacy evaluation of prophylactic cranial irradiation for limited stage small‑cell lung cancer in the magnetic resonance imaging era: A meta‑analysis". Oncology Letters 29.3 (2025): 123.
Chicago
Shao, L., Dong, Y., Jiang, M., Song, H., Qi, Y., Guo, L., Tian, J., Wei, S."Efficacy evaluation of prophylactic cranial irradiation for limited stage small‑cell lung cancer in the magnetic resonance imaging era: A meta‑analysis". Oncology Letters 29, no. 3 (2025): 123. https://doi.org/10.3892/ol.2025.14870
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