Urothelial carcinoma metastasis to the appendix as the first manifestation of dissemination after radical cystectomy: A case report

Nalej,Pawel; Kalinowski,Piotr; Kuczkiewicz-Siemion,Olga; Adamowicz,Bernard; Kalinowski,Tomasz; Demkow,Tomasz

doi:10.3892/ol.2025.14909

March-2025 Volume 29 Issue 3

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March-2025 Volume 29 Issue 3

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Case Report Open Access

Urothelial carcinoma metastasis to the appendix as the first manifestation of dissemination after radical cystectomy: A case report

Authors:
- Pawel Nalej
- Piotr Kalinowski
- Olga Kuczkiewicz-Siemion
- Bernard Adamowicz
- Tomasz Kalinowski
- Tomasz Demkow
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Affiliations: Department of Urogenital Cancer, Maria Skłodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland

Copyright: © Nalej et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 163
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Published online on: January 27, 2025

https://doi.org/10.3892/ol.2025.14909
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Abstract

Urothelial carcinoma of the urinary tract is the seventh most commonly diagnosed cancer in men and the 10th most common when both genders are considered. The most common site of malignancy in the urinary tract is the bladder. Radical cystectomy with urinary diversion is considered the best treatment option for patients with advanced urothelial bladder cancer. The most common long‑term complication of urinary diversion is the deterioration of renal function, mainly caused by uretero‑enteric strictures. Malignant neoplasms of the appendix are rare and metastatic involvement of the appendix during the course of any neoplastic disease is very rare. The current study presents a unique case of a 67‑year‑old man with urothelial cancer metastasis to the appendix, which was accidentally detected in an inflamed appendix removed during surgical treatment of an uretero‑enteric stricture after radical cystectomy. To the best of our knowledge, bladder cancer metastasis to the appendix has not been previously reported as the first manifestation of dissemination. This case report provides evidence expanding the spectrum of known forms of metastatic urothelial carcinoma and may help in the development of guidelines for the surveillance and treatment of bladder cancer.

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1	EAU Guidelines, . Edn. presented at the EAU Annual Congress Paris. 2024.ISBN 978-94-92671-23-3.
2	Eisenberg MS, Thompson RH, Frank I, Kim SP, Cotter KJ, Tollefson MK, Kaushik D, Thapa P, Tarrell R and Boorjian SA: Long-term renal function outcomes after radical cystectomy. J Urol. 191:619–625. 2014. View Article : Google Scholar : PubMed/NCBI
3	Jin XD, Roethlisberger S, Burkhard FC, Birkhaeuser F, Thoeny HC and Studer UE: Long-term renal function after urinary diversion by ileal conduit or orthotopic ileal bladder substitution. Eur Urol. 61:491–497. 2012. View Article : Google Scholar : PubMed/NCBI
4	Ericson KJ, Thomas LJ, Zhang JH, Knorr JM, Khanna A, Crane A, Zampini AM, Murthy PB, Berglund RK, Pascal-Haber G and Lee BHL: Uretero-enteric anastomotic stricture following radical cystectomy: A comparison of open, robotic extracorporeal, and robotic intracorporeal approaches. Urology. 144:130–135. 2020. View Article : Google Scholar : PubMed/NCBI
5	Krafft U, Mahmoud O, Hess J, Radtke JP, Panic A, Püllen L, Darr C, Kesch C, Szarvas T, Rehme C, et al: Comparative analysis of bricker versus wallace ureteroenteric anastomosis and identification of predictors for postoperative ureteroenteric stricture. Langenbecks Arch Surg. 407:1233–1240. 2022. View Article : Google Scholar : PubMed/NCBI
6	Albisinni S, Aoun F, Mjaess G, Abou Zahr R, Diamand R, Porpiglia F, Esperto F, Autorino R, Fiori C, Tubaro A, et al: Contemporary management of benign uretero-enteric strictures after cystectomy: A systematic review. Minerva Urol Nephrol. 73:724–730. 2021.PubMed/NCBI
7	Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Thangathurai D, Mikhail M, et al: Radical cystectomy in the treatment of invasive bladder cancer: Long-term results in 1,054 patients. J Clin Oncol. 19:666–675. 2001. View Article : Google Scholar : PubMed/NCBI
8	Mari A, Campi R, Tellini R, Gandaglia G, Albisinni S, Abufaraj M, Hatzichristodoulou G, Montorsi F, van Velthoven R, Carini M, et al: Patterns and predictors of recurrence after open radical cystectomy for bladder cancer: A comprehensive review of the literature. World J Urol. 36:157–170. 2018. View Article : Google Scholar : PubMed/NCBI
9	Ghoneim MA, Abdel-Latif M, el-Mekresh M, Abol-Enein H, Mosbah A, Ashamallah A and el-Baz MA: Radical cystectomy for carcinoma of the bladder: 2,720 consecutive cases 5 years later. J Urol. 180:121–127. 2008. View Article : Google Scholar : PubMed/NCBI
10	Wu ZS, Ding W, Cai J, Bashir G, Li YQ and Wu S: Communication of cancer cells and lymphatic vessels in cancer: Focus on bladder cancer. Onco Targets Ther. 12:8161–8177. 2019. View Article : Google Scholar : PubMed/NCBI
11	Lyss AP: Appendiceal malignancies. Semin Oncol. 15:129–137. 1988.PubMed/NCBI
12	Yadav S, Mittal N, Kumar R, Janu A and Prabhash K: Metastasis to appendix presenting as acute appendicitis-A rare case report and review of literature. J Gastrointest Cancer. 52:1114–1118. 2021. View Article : Google Scholar : PubMed/NCBI
13	Connor SJ, Hanna GB and Frizelle FA: Appendiceal tumors: Retrospective clinicopathologic analysis of appendiceal tumors from 7,970 appendectomies. Dis Colon Rectum. 41:75–80. 1998. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Urothelial carcinoma metastasis to the appendix as the first manifestation of dissemination after radical cystectomy: A case report

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