Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2025 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2025 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Association between triglyceride‑glucose index as a marker of insulin resistance and the risk of malignant melanoma: A retrospective study

  • Authors:
    • Jiukang Sun
    • Zhihang Han
    • Chuanjun Song
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, P.R. China, Department of Oncology, Xinghua People's Hospital Affiliated to Yangzhou University, Xinghua, Jiangsu 225700, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 173
    |
    Published online on: February 7, 2025
       https://doi.org/10.3892/ol.2025.14919
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Malignant melanoma, a highly malignant tumor predominantly found on the skin surface, has exhibited an alarming rise in both incidence and mortality rates annually since 2012. Despite its relatively low occurrence among skin malignancies, the mortality rate of malignant melanoma remains disproportionately high. The prognosis relies heavily on early stage detection, with a significant disparity in survival rates between stage I and stage IV patients. Studies exploring insulin resistance (IR) as a potential risk factor for malignant melanoma are scarce. The present study therefore investigated the association between the triglyceride glucose (TyG) index, an indicator of IR, and malignant melanoma incidence. Retrospective data from patients diagnosed with malignant melanoma at the First Affiliated Hospital of Nanjing Medical University (Nanjing, China) between January 2019 and January 2024 were collected. Basic information, including age, sex and body mass index, and hematological test results, such as those for fasting triglycerides and fasting blood glucose, were analyzed. Logistic regression analysis and receiver operating characteristic (ROC) curve analysis were employed to explore the association between melanoma risk and the TyG index. A total of 403 participants, including 272 patients with malignant melanomas and 131 patients with nevi, were included in the study. The melanoma group exhibited significantly higher levels of the TyG index compared with the control group (P<0.001). Univariate and multivariable logistic regression analyses revealed the TyG index as an independent risk factor for melanoma incidence (OR, 6.33; 95% CI, 3.56‑11.27; P<0.001). Incidence rates of melanoma significantly increased across tertiles of the TyG index (P<0.001). The ROC curve analysis identified a clinically acceptable predictive cutoff point for the TyG index. The present study therefore provides evidence that the TyG index is a significant risk factor for the incidence of malignant melanoma. The findings underscore the potential utility of the TyG index as a biomarker for diagnosing melanoma and suggest new avenues for melanoma treatment strategies.
View Figures

Figure 1

Figure 2

View References

1 

Raimondi S, Suppa M and Gandini S: Melanoma epidemiology and sun exposure. Acta Derm Venereol. 100:adv001362020. View Article : Google Scholar : PubMed/NCBI

2 

Waseh S and Lee JB: Advances in melanoma: Epidemiology, diagnosis, and prognosis. Front Med (Lausanne). 10:12684792023. View Article : Google Scholar : PubMed/NCBI

3 

Eisemann N, Schumann L, Baltus H, Labohm L, Kraywinkel K and Katalinic A: Longer survival from melanoma in Germany. Dtsch Arztebl Int. 121:45–51. 2024.PubMed/NCBI

4 

Toussi A, Mans N, Welborn J and Kiuru M: Germline mutations predisposing to melanoma. J Cutan Pathol. 47:606–616. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Holly EA, Kelly JW, Shpall SN and Chiu SH: Number of melanocytic nevi as a major risk factor for malignant melanoma. J Am Acad Dermatol. 17:459–468. 1987. View Article : Google Scholar : PubMed/NCBI

6 

Fears TR, Scotto J and Schneiderman MA: Mathematical models of age and ultraviolet effects on the incidence of skin cancer among whites in the United States. Am J Epidemiol. 105:420–427. 1977. View Article : Google Scholar : PubMed/NCBI

7 

Chen S, Chen Y, Liu X, Li M, Wu B, Li Y, Liang Y, Shao X, Holthöfer H and Zou H: Insulin resistance and metabolic syndrome in normal-weight individuals. Endocrine. 46:496–504. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Fracanzani AL, Valenti L, Bugianesi E, Andreoletti M, Colli A, Vanni E, Bertelli C, Fatta E, Bignamini D, Marchesini G and Fargion S: Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes. Hepatology. 48:792–798. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Czech MP: Mechanisms of insulin resistance related to white, beige, and brown adipocytes. Mol Metab. 34:27–42. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Yan X, Gao Y, Tong J, Tian M, Dai J and Zhuang Y: Association between triglyceride glucose index and non-small cell lung cancer risk in Chinese population. Front Oncol. 11:5853882021. View Article : Google Scholar : PubMed/NCBI

11 

Panigoro SS, Sutandyo N, Witjaksono F, Siregar NC, Ramli R, Hariani R, Pangarsa EA, Prajoko YW, Puruhita N, Hamdani W, et al: The association between triglyceride-glucose index as a marker of insulin resistance and the risk of breast cancer. Front Endocrinol (Lausanne). 12:7452362021. View Article : Google Scholar : PubMed/NCBI

12 

Alkurt EG, Şahin F, Tutan B, Canal K and Turhan VB: The relationship between papillary thyroid cancer and triglyceride/glucose index, which is an indicator of insulin resistance. Eur Rev Med Pharmacol Sci. 26:6114–6120. 2022.PubMed/NCBI

13 

Li W, Liu T, Qian L, Wang Y, Ma X, Cao L, Zhang Q and Qu J: Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk. Front Endocrinol (Lausanne). 13:9831602022. View Article : Google Scholar : PubMed/NCBI

14 

DeFronzo RA, Tobin JD and Andres R: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol. 237:E214–E223. 1979.PubMed/NCBI

15 

Sánchez-García A, Rodríguez-Gutiérrez R, Mancillas-Adame L, González-Nava V, Díaz González-Colmenero A, Solis RC, Álvarez-Villalobos NA and González-González JG: Diagnostic accuracy of the triglyceride and glucose index for insulin resistance: A systematic review. Int J Endocrinol. 2020:46785262020. View Article : Google Scholar : PubMed/NCBI

16 

Rohm TV, Meier DT, Olefsky JM and Donath MY: Inflammation in obesity, diabetes, and related disorders. Immunity. 55:31–55. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Kim DS and Scherer PE: Obesity, diabetes, and increased cancer progression. Diabetes Metab J. 45:799–812. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Poznyak A, Grechko AV, Poggio P, Myasoedova VA, Alfieri V and Orekhov AN: The diabetes mellitus-atherosclerosis connection: The role of lipid and glucose metabolism and chronic inflammation. Int J Mol Sci. 21:18352020. View Article : Google Scholar : PubMed/NCBI

19 

Gado M, Tsaousidou E, Bornstein SR and Perakakis N: Sex-based differences in insulin resistance. J Endocrinol. 261:e2302452024. View Article : Google Scholar : PubMed/NCBI

20 

Bagnardi V, Rota M, Botteri E, Tramacere I, Islami F, Fedirko V, Scotti L, Jenab M, Turati F, Pasquali E, et al: Alcohol consumption and site-specific cancer risk: A comprehensive dose-response meta-analysis. Br J Cancer. 112:580–593. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Saladi RN, Nektalova T and Fox JL: Induction of skin carcinogenicity by alcohol and ultraviolet light. Clin Exp Dermatol. 35:7–11. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Xu J, Liu W, Liu X, Zhou X and Li G: Alcohol drinking, smoking, and cutaneous melanoma risk: Mendelian randomization analysis. Gac Sanit. 37:1023512023. View Article : Google Scholar : PubMed/NCBI

23 

Gandini S, Masala G, Palli D, Cavicchi B, Saieva C, Ermini I, Baldini F, Gnagnarella P and Caini S: Alcohol, alcoholic beverages, and melanoma risk: A systematic literature review and dose-response meta-analysis. Eur J Nutr. 57:2323–2332. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Reaven GM: Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 37:1595–1607. 1988. View Article : Google Scholar : PubMed/NCBI

25 

Pan K, Chlebowski RT, Mortimer JE, Gunter MJ, Rohan T, Vitolins MZ, Adams-Campbell LL, Ho GYF, Cheng TD and Nelson RA: Insulin resistance and breast cancer incidence and mortality in postmenopausal women in the women's health initiative. Cancer. 126:3638–3647. 2020. View Article : Google Scholar : PubMed/NCBI

26 

Qin G, Sun Z, Jin Y, Ren X, Zhang Z, Wang S, Zhou G, Huang K, Zhao H and Jiang X: The association between the triglyceride-glucose index and prognosis in postoperative renal cell carcinoma patients: A retrospective cohort study. Front Endocrinol (Lausanne). 15:13017032024. View Article : Google Scholar : PubMed/NCBI

27 

Zhang AMY, Wellberg EA, Kopp JL and Johnson JD: Hyperinsulinemia in obesity, inflammation, and cancer. Diabetes Metab J. 45:285–311. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Lien EC, Lyssiotis CA and Cantley LC: Metabolic reprogramming by the PI3K-Akt-mTOR pathway in cancer. Recent Results Cancer Res. 207:39–72. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Belfiore A, Frasca F, Pandini G, Sciacca L and Vigneri R: Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev. 30:586–623. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Zhang AMY, Magrill J, de Winter TJJ, Hu X, Skovsø S, Schaeffer DF, Kopp JL and Johnson JD: Endogenous hyperinsulinemia contributes to pancreatic cancer development. Cell Metab. 30:403–404. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Stolzenberg-Solomon RZ, Graubard BI, Chari S, Limburg P, Taylor PR, Virtamo J and Albanes D: Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers. JAMA. 294:2872–2878. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Lv Z and Guo Y: Metformin and its benefits for various diseases. Front Endocrinol (Lausanne). 11:1912020. View Article : Google Scholar : PubMed/NCBI

33 

Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE and Shaw RJ: AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 30:214–226. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Podhorecka M, Ibanez B and Dmoszyńska A: Metformin-its potential anti-cancer and anti-aging effects. Postepy Hig Med Dosw (Online). 71:170–175. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Vallianou NG, Evangelopoulos A and Kazazis C: Metformin and cancer. Rev Diabet Stud. 10:228–235. 2023. View Article : Google Scholar : PubMed/NCBI

36 

Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, Goldfine ID, Belfiore A and Vigneri R: Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol. 19:3278–3288. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Zhong W, Wang X, Wang Y, Sun G, Zhang J and Li Z: Obesity and endocrine-related cancer: The important role of IGF-1. Front Endocrinol (Lausanne). 14:10932572023. View Article : Google Scholar : PubMed/NCBI

38 

Wang S, Wang N, Yu B, Cao M, Wang Y, Guo Y, Zhang Y, Zhang P, Yu X, Wang S, et al: Circulating IGF-1 promotes prostate adenocarcinoma via FOXO3A/BIM signaling in a double-transgenic mouse model. Oncogene. 38:6338–6353. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Yakar S, Pennisi P, Zhao H, Zhang Y and LeRoith D: Circulating IGF-1 and its role in cancer: Lessons from the IGF-1 gene deletion (LID) mouse. Novartis Found Symp. 262:3–18. 265–268. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Malaguarnera R, Sacco A, Voci C, Pandini G, Vigneri R and Belfiore A: Proinsulin binds with high affinity the insulin receptor isoform A and predominantly activates the mitogenic pathway. Endocrinology. 153:2152–2163. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Ortega-Molina A and Serrano M: PTEN in cancer, metabolism, and aging. Trends Endocrinol Metab. 24:184–189. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Cheng H, Liu P, Zhang F, Xu E, Symonds L, Ohlson CE, Bronson RT, Maira SM, Di Tomaso E, Li J, et al: A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 is highly responsive to mTOR inhibition. Cancer Res. 74:15–23. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Chen J, Zhang XD and Proud C: Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice. Sci Signal. 8:pe12015. View Article : Google Scholar : PubMed/NCBI

44 

Wang XL, Zhang L, Youker K, Zhang MX, Wang J, LeMaire SA, Coselli JS and Shen YH: Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase. Diabetes. 55:2301–2310. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Yu J, Shen J, Sun TT, Zhang X and Wong N: Obesity, insulin resistance, NASH and hepatocellular carcinoma. Semin Cancer Biol. 23:483–491. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Leachman SA, Lucero OM, Sampson JE, Cassidy P, Bruno W, Queirolo P and Ghiorzo P: Identification, genetic testing, and management of hereditary melanoma. Cancer Metastasis Rev. 36:77–90. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Olefsky JM and Glass CK: Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 72:219–246. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Kershaw EE and Flier JS: Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 89:2548–2556. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Vozarova B, Weyer C, Hanson K, Tataranni PA, Bogardus C and Pratley RE: Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res. 9:414–417. 2001. View Article : Google Scholar : PubMed/NCBI

50 

Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L and Karin M: IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 15:103–113. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Gonullu G, Ersoy C, Ersoy A, Evrensel T, Basturk B, Kurt E, Oral B, Gokgoz S and Manavoglu O: Relation between insulin resistance and serum concentrations of IL-6 and TNF-alpha in overweight or obese women with early stage breast cancer. Cytokine. 31:264–269. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Wu CT, Chen MF, Chen WC and Hsieh CC: The role of IL-6 in the radiation response of prostate cancer. Radiat Oncol. 8:1592013. View Article : Google Scholar : PubMed/NCBI

53 

Bulló M, García-Lorda P, Peinado-Onsurbe J, Hernández M, Del Castillo D, Argilés JM and Salas-Salvadó J: TNFalpha expression of subcutaneous adipose tissue in obese and morbid obese females: Relationship to adipocyte LPL activity and leptin synthesis. Int J Obes Relat Metab Disord. 26:652–658. 2002. View Article : Google Scholar : PubMed/NCBI

54 

Michalaki V, Syrigos K, Charles P and Waxman J: Serum levels of IL-6 and TNF-alpha correlate with clinicopathological features and patient survival in patients with prostate cancer. Br J Cancer. 90:2312–2316. 2004. View Article : Google Scholar : PubMed/NCBI

55 

Cruceriu D, Baldasici O, Balacescu O and Berindan-Neagoe I: The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: Molecular insights and therapeutic approaches. Cell Oncol (Dordr). 43:1–18. 2020. View Article : Google Scholar : PubMed/NCBI

56 

Pfalzer AC, Leung K, Crott JW, Kim SJ, Tai AK, Parnell LD, Kamanu FK, Liu Z, Rogers G, Shea MK, et al: Incremental elevations in TNFα and IL6 in the human colon and procancerous changes in the mucosal transcriptome accompany adiposity. Cancer Epidemiol Biomarkers Prev. 27:1416–1423. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Zheng YJ, Ho W, Sanlorenzo M, Vujic I, Daud A, Algazi A, Rappersberger K and Ortiz-Urda S: Melanoma risk during immunomodulating treatment. Melanoma Res. 32:411–418. 2022. View Article : Google Scholar : PubMed/NCBI

58 

Molinelli E, Ceccarelli G, Fantone S, Di Mercurio E, Gambini D, Maurizi A, Perugini J, Tossetta G, Brisigotti V, De Simoni E, et al: Melanoma and subcutaneous adipose tissue: Role of peritumoral adipokines in disease characterization and prognosis. Pigment Cell Melanoma Res. 36:423–430. 2023. View Article : Google Scholar : PubMed/NCBI

59 

Sims EK, Carr ALJ, Oram RA, DiMeglio LA and Evans-Molina C: 100 Years of insulin: Celebrating the past, present and future of diabetes therapy. Nat Med. 27:1154–1164. 2021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun J, Han Z and Song C: Association between triglyceride‑glucose index as a marker of insulin resistance and the risk of malignant melanoma: A retrospective study. Oncol Lett 29: 173, 2025.
APA
Sun, J., Han, Z., & Song, C. (2025). Association between triglyceride‑glucose index as a marker of insulin resistance and the risk of malignant melanoma: A retrospective study. Oncology Letters, 29, 173. https://doi.org/10.3892/ol.2025.14919
MLA
Sun, J., Han, Z., Song, C."Association between triglyceride‑glucose index as a marker of insulin resistance and the risk of malignant melanoma: A retrospective study". Oncology Letters 29.4 (2025): 173.
Chicago
Sun, J., Han, Z., Song, C."Association between triglyceride‑glucose index as a marker of insulin resistance and the risk of malignant melanoma: A retrospective study". Oncology Letters 29, no. 4 (2025): 173. https://doi.org/10.3892/ol.2025.14919
Copy and paste a formatted citation
x
Spandidos Publications style
Sun J, Han Z and Song C: Association between triglyceride‑glucose index as a marker of insulin resistance and the risk of malignant melanoma: A retrospective study. Oncol Lett 29: 173, 2025.
APA
Sun, J., Han, Z., & Song, C. (2025). Association between triglyceride‑glucose index as a marker of insulin resistance and the risk of malignant melanoma: A retrospective study. Oncology Letters, 29, 173. https://doi.org/10.3892/ol.2025.14919
MLA
Sun, J., Han, Z., Song, C."Association between triglyceride‑glucose index as a marker of insulin resistance and the risk of malignant melanoma: A retrospective study". Oncology Letters 29.4 (2025): 173.
Chicago
Sun, J., Han, Z., Song, C."Association between triglyceride‑glucose index as a marker of insulin resistance and the risk of malignant melanoma: A retrospective study". Oncology Letters 29, no. 4 (2025): 173. https://doi.org/10.3892/ol.2025.14919
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team