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Profile and clinical significance of SPARCL1 and its prognostic significance in breast cancer

  • Authors:
    • Xin-Yu Xu
    • Ying-Wen Han
    • Yun-Xiao Song
    • Zhen-Yu Zhou
    • Shu Chen
    • Yu-Wei Liu
    • Ying Zhou
    • Jie Chen
  • View Affiliations / Copyright

    Affiliations: Medical Laboratory, Department of General Medicine, Zhongshan‑Xuhui Hospital, Fudan University, Shanghai 200031, P.R. China, Department of Nuclear Medicine, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, P.R. China, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212003, P.R. China, Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Department of General Medicine, Zhongshan‑Xuhui Hospital, Fudan University, Shanghai 200031, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 196
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    Published online on: February 24, 2025
       https://doi.org/10.3892/ol.2025.14942
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Abstract

Secreted protein acidic and cysteine‑rich like 1 (SPARCL1; also known as MAST9) exhibits low expression levels in several malignant tumors and is positively associated with tumor growth and poor prognosis. Furthermore, there may be an association between SPARCL1 and breast cancer; however, further comprehensive research is necessary. The present study assessed the relationship between SPARCL1 expression and breast cancer using RNA sequencing and clinical data from The Cancer Genome Atlas database (including tumor mutations, immune infiltration and prognosis data), cell experiments and clinical samples. The findings indicated that SPARCL1 expression was significantly lower in breast cancer tissues compared with other malignant tumors, with its downregulation negatively associated with the overall survival rate of patients. Moreover, analysis of receiver operator characteristic curve analysis, and univariate and multivariate Cox regression models suggested that SPARCL1 has potential as a diagnostic biomarker for breast cancer detection. Additionally, low expression of SPARCL1 was demonstrated to be associated with the degree of immune infiltration, whilst functional enrichment analysis revealed its involvement in key areas such as cell cycle regulation, protein/ATP binding processes, cellular aging mechanisms, oocyte meiosis pathways and DNA replication processes. Overall, the results of the present study highlight how big data mining combined with experimental verification can provide insights into the role of SPARCL1 in breast cancer pathogenesis and its potential as a biomarker for the disease. However, further investigations are warranted to validate these findings and provide a more comprehensive understanding of the implications of SPARCL1 therapy in patients with breast cancer.
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View References

1 

Akram M, Iqbal M, Daniyal M and Khan AU: Awareness and current knowledge of breast cancer. Biol Res. 50:332017. View Article : Google Scholar : PubMed/NCBI

2 

Kolak A, Kamińska M, Sygit K, Budny A, Surdyka D, Kukiełka-Budny B and Burdan F: Primary and secondary prevention of breast cancer. Ann Agric Environ Med. 24:549–553. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Barzaman K, Karami J, Zarei Z, Hosseinzadeh A, Kazemi MH, Moradi-Kalbolandi S, Safari E and Farahmand L: Breast cancer: Biology, biomarkers, and treatments. Int Immunopharmacol. 84:1065352020. View Article : Google Scholar : PubMed/NCBI

4 

Derakhshan F and Reis-Filho JS: Pathogenesis of triple-negative breast cancer. Annu Rev Pathol. 17:181–204. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Yin L, Duan JJ, Bian XW and Yu SC: Triple-negative breast cancer molecular subtyping and treatment progress. Breast Cancer Res. 22:612020. View Article : Google Scholar : PubMed/NCBI

6 

Howard FM and Olopade OI: Epidemiology of triple-negative breast cancer: A review. Cancer J. 27:8–16. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Russo A, Incorvaia L, Capoluongo E, Tagliaferri P, Gori S, Cortesi L, Genuardi M, Turchetti D, De Giorgi U, Di Maio M, et al: Implementation of preventive and predictive BRCA testing in patients with breast, ovarian, pancreatic, and prostate cancer: A position paper of Italian scientific societies. ESMO Open. 7:1004592022. View Article : Google Scholar : PubMed/NCBI

8 

Copson ER, Maishman TC, Tapper WJ, Cutress RI, Greville-Heygate S, Altman DG, Eccles B, Gerty S, Durcan LT, Jones L, et al: Germline BRCA mutation and outcome in young-onset breast cancer (POSH): A prospective cohort study. Lancet Oncol. 19:169–180. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Gagliardi F, Narayanan A and Mortini P: SPARCL1 a novel player in cancer biology. Crit Rev Oncol Hematol. 109:63–68. 2017. View Article : Google Scholar : PubMed/NCBI

10 

He K, Li C, Yuan H, Jiang K and Deng G: Immunological role and prognostic value of SPARCL1 in pan-cancer analysis. Pathol Oncol Res. 28:16106872022. View Article : Google Scholar : PubMed/NCBI

11 

Zhou Y and Zhang Q: Association of tumor suppressor sparcl1 with clinical staging and prognosis of NSCLC. Ann Clin Lab Sci. 51:756–765. 2021.PubMed/NCBI

12 

Hu H, Cai W, Zheng S and Ge W: SPARCL1, a novel prognostic predictive factor for GI malignancies: a meta-analysis. Cell Physiol Biochem. 44:1485–1496. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Cao F, Wang K, Zhu R, Hu YW, Fang WZ and Ding HZ: Clinicopathological significance of reduced SPARCL1 expression in human breast cancer. Asian Pac J Cancer Prev. 14:195–200. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Chen M, Zheng W and Fang L: Identifying liver metastasis-related hub genes in breast cancer and characterizing SPARCL1 as a potential prognostic biomarker. PeerJ. 11:e153112023. View Article : Google Scholar : PubMed/NCBI

15 

Su Z, Wang G and Li L: CHRDL1, NEFH, TAGLN and SYNM as novel diagnostic biomarkers of benign prostatic hyperplasia and prostate cancer. Cancer Biomark. 38:143–159. 2023. View Article : Google Scholar : PubMed/NCBI

16 

Oliveras-Ferraros C, Vazquez-Martin A, Cuyàs E, Corominas-Faja B, Rodríguez-Gallego E, Fernández-Arroyo S, Martin-Castillo B, Joven J and Menendez JA: Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile. Cell Cycle. 13:1132–1144. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, Netto GJ, Qin ZS, Kumar S, Manne U, et al: UALCAN: An update to the integrated cancer data analysis platform. Neoplasia. 25:18–27. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Chen F, Zhang Y, Chandrashekar DS, Varambally S and Creighton CJ: Global impact of somatic structural variation on the cancer proteome. Nat Commun. 14:56372023. View Article : Google Scholar : PubMed/NCBI

20 

Tang Z, Kang B, Li C, Chen T and Zhang Z: GEPIA2: An enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res 47 (W1). W556–W560. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Jézéquel P, Campone M, Gouraud W, Guérin-Charbonnel C, Leux C, Ricolleau G and Campion L: bc-GenExMiner: An easy-to-use online platform for gene prognostic analyses in breast cancer. Breast Cancer Res Treat. 131:765–775. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Jézéquel P, Gouraud W, Ben Azzouz F, Guérin-Charbonnel C, Juin PP, Lasla H and Campone M: bc-GenExMiner 4.5: New mining module computes breast cancer differential gene expression analyses. Database (Oxford). 2021:baab0072021. View Article : Google Scholar : PubMed/NCBI

23 

Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A and Muñoz M: Clinical implications of the intrinsic molecular subtypes of breast cancer. Breast. 24 (Suppl 2):S26–S35. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Győrffy B: Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer. Comput Struct Biotechnol J. 19:4101–4109. 2021. View Article : Google Scholar : PubMed/NCBI

25 

Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B and Liu XS: TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res 48 (W1). W509–W514. 2020. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Kim YM, Kang M, Choi JH, Lee BH, Kim GH, Ohn JH, Kim SY, Park MS and Yoo HW: A review of the literature on common CYP17A1 mutations in adults with 17-hydroxylase/17,20-lyase deficiency, a case series of such mutations among Koreans and functional characteristics of a novel mutation. Metabolism. 63:42–49. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Vasaikar SV, Straub P, Wang J and Zhang B: LinkedOmics: Analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res. 46(D1): D956–D963. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Edge SB and Compton CC: The American joint committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Olawaiye AB, Baker TP, Washington MK and Mutch DG: The new (version 9) American joint committee on cancer tumor, node, metastasis staging for cervical cancer. CA Cancer J Clin. 71:287–298. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Stanton SE and Disis ML: Clinical significance of tumor-infiltrating lymphocytes in breast cancer. J Immunother Cancer. 4:592016. View Article : Google Scholar : PubMed/NCBI

32 

Lu H, Lou H, Wengert G, Paudel R, Patel N, Desai S, Crum B, Linton-Reid K, Chen M, Li D, et al: Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer. Cell Rep Med. 4:1010922023. View Article : Google Scholar : PubMed/NCBI

33 

Thorat MA and Balasubramanian R: Breast cancer prevention in high-risk women. Best Pract Res Clin Obstet Gynaecol. 65:18–31. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Winters S, Martin C, Murphy D and Shokar NK: Breast cancer epidemiology, prevention, and screening. Prog Mol Biol Transl Sci. 151:1–32. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Maughan KL, Lutterbie MA and Ham PS: Treatment of breast cancer. Am Fam Physician. 81:1339–1346. 2010.PubMed/NCBI

36 

Peart O: Breast intervention and breast cancer treatment options. Radiol Technol. 86:535M–562M. 2015.PubMed/NCBI

37 

Ben-Dror J, Shalamov M and Sonnenblick A: The history of early breast cancer treatment. Genes (Basel). 13:9602022. View Article : Google Scholar : PubMed/NCBI

38 

Tesch ME and Partridge AH: Treatment of breast cancer in young adults. Am Soc Clin Oncol Educ Book. 42:1–12. 2022.PubMed/NCBI

39 

Zhang HP, Wu J, Liu ZF, Gao JW and Li SY: SPARCL1 is a novel prognostic biomarker and correlates with tumor microenvironment in colorectal cancer. Biomed Res Int. 2022:13982682022. View Article : Google Scholar : PubMed/NCBI

40 

Yu Y, Chen Y, Ma J, Yu X, Yu G and Li Z: SPARCL1 is a novel predictor of tumor recurrence and survival in hilar cholangiocarcinoma. Tumour Biol. 37:4159–4167. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Gao S, Gang J, Yu M, Xin G and Tan H: Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer. BMC Cancer. 21:7912021. View Article : Google Scholar : PubMed/NCBI

42 

Li H, Lei Y, Li G and Huang Y: Identification of tumor-suppressor genes in lung squamous cell carcinoma through integrated bioinformatics analyses. Oncol Res. 32:187–197. 2023. View Article : Google Scholar : PubMed/NCBI

43 

Yang H, Zou X, Yang S, Zhang A, Li N and Ma Z: Identification of lactylation related model to predict prognostic, tumor infiltrating immunocytes and response of immunotherapy in gastric cancer. Front Immunol. 14:11499892023. View Article : Google Scholar : PubMed/NCBI

44 

Zhao H, Luo K, Liu M, Cai Y, Liu S, Li S, Zhao Y and Zhang H: Immune regulation and prognostic prediction model establishment and validation of PSMB6 in lung adenocarcinoma. Front Genet. 15:14580472024. View Article : Google Scholar : PubMed/NCBI

45 

Xiao X, Peng J, Chen Y, Lu X, Sun W, Xiao W, Yuan M and Huang X: Comprehensive analysis of differential gene expression and correlated immune infiltration in bladder cancer. Iran J Public Health. 52:1225–1237. 2023.PubMed/NCBI

46 

Chen Z, Sun X, Kang Y, Zhang J, Jia F, Liu X and Zhu H: A novel risk model based on the correlation between the expression of basement membrane genes and immune infiltration to predict the invasiveness of pituitary adenomas. Front Endocrinol (Lausanne). 13:10797772023. View Article : Google Scholar : PubMed/NCBI

47 

Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, et al: Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. bioRxiv [Preprint]. 2023.05.25.541966. 2023.

48 

Strunz M, Jarrell JT, Cohen DS, Rosin ER, Vanderburg CR and Huang X: Modulation of SPARC/hevin proteins in Alzheimer's disease brain injury. J Alzheimers Dis. 68:695–710. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Sheybani ND, Witter AR, Garrison WJ, Miller GW, Price RJ and Bullock TNJ: Profiling of the immune landscape in murine glioblastoma following blood brain/tumor barrier disruption with MR image-guided focused ultrasound. J Neurooncol. 156:109–122. 2022. View Article : Google Scholar : PubMed/NCBI

50 

Sadique FL, Subramaiam H, Krishnappa P, Chellappan DK and Ma JH: Recent advances in breast cancer metastasis with special emphasis on metastasis to the brain. Pathol Res Pract. 260:1553782024. View Article : Google Scholar : PubMed/NCBI

51 

Ersahin T, Tuncbag N and Cetin-Atalay R: The PI3K/AKT/mTOR interactive pathway. Mol Biosyst. 11:1946–1954. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Xu F, Na L, Li Y and Chen L: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours. Cell Biosci. 10:542020. View Article : Google Scholar : PubMed/NCBI

53 

Carnero A, Blanco-Aparicio C, Renner O, Link W and Leal JF: The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets. 8:187–198. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Li G, Zhang C, Liang W, Zhang Y, Shen Y and Tian X: Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells. Pharm Biol. 59:21–30. 2021. View Article : Google Scholar : PubMed/NCBI

55 

Zhu L, Yang F, Wang G and Li Q: CXC motif chemokine receptor type 4 disrupts blood-brain barrier and promotes brain metastasis through activation of the PI3K/AKT pathway in lung cancer. World Neurosurg. 166:e369–e381. 2022. View Article : Google Scholar : PubMed/NCBI

56 

Tusup M, Kündig TM and Pascolo S: Epitranscriptomics modifier pentostatin indirectly triggers Toll-like receptor 3 and can enhance immune infiltration in tumors. Mol Ther. 30:1163–1170. 2022. View Article : Google Scholar : PubMed/NCBI

57 

Pan M, Wei X, Xiang X, Liu Y, Zhou Q and Yang W: Targeting CXCL9/10/11-CXCR3 axis: An important component of tumor-promoting and antitumor immunity. Clin Transl Oncol. 25:2306–2320. 2023. View Article : Google Scholar : PubMed/NCBI

58 

Wu J, Yang S, Gou F, Zhou Z, Xie P, Xu N and Dai Z: Intelligent segmentation medical assistance system for MRI images of osteosarcoma in developing countries. Comput Math Methods Med. 2022:77035832022.PubMed/NCBI

59 

Gygi JP, Kleinstein SH and Guan L: Predictive overfitting in immunological applications: Pitfalls and solutions. Hum Vaccin Immunother. 19:22518302023. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Han Y, Song Y, Zhou Z, Chen S, Liu Y, Zhou Y and Chen J: Profile and clinical significance of SPARCL1 and its prognostic significance in breast cancer. Oncol Lett 29: 196, 2025.
APA
Xu, X., Han, Y., Song, Y., Zhou, Z., Chen, S., Liu, Y. ... Chen, J. (2025). Profile and clinical significance of SPARCL1 and its prognostic significance in breast cancer. Oncology Letters, 29, 196. https://doi.org/10.3892/ol.2025.14942
MLA
Xu, X., Han, Y., Song, Y., Zhou, Z., Chen, S., Liu, Y., Zhou, Y., Chen, J."Profile and clinical significance of SPARCL1 and its prognostic significance in breast cancer". Oncology Letters 29.4 (2025): 196.
Chicago
Xu, X., Han, Y., Song, Y., Zhou, Z., Chen, S., Liu, Y., Zhou, Y., Chen, J."Profile and clinical significance of SPARCL1 and its prognostic significance in breast cancer". Oncology Letters 29, no. 4 (2025): 196. https://doi.org/10.3892/ol.2025.14942
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Han Y, Song Y, Zhou Z, Chen S, Liu Y, Zhou Y and Chen J: Profile and clinical significance of SPARCL1 and its prognostic significance in breast cancer. Oncol Lett 29: 196, 2025.
APA
Xu, X., Han, Y., Song, Y., Zhou, Z., Chen, S., Liu, Y. ... Chen, J. (2025). Profile and clinical significance of SPARCL1 and its prognostic significance in breast cancer. Oncology Letters, 29, 196. https://doi.org/10.3892/ol.2025.14942
MLA
Xu, X., Han, Y., Song, Y., Zhou, Z., Chen, S., Liu, Y., Zhou, Y., Chen, J."Profile and clinical significance of SPARCL1 and its prognostic significance in breast cancer". Oncology Letters 29.4 (2025): 196.
Chicago
Xu, X., Han, Y., Song, Y., Zhou, Z., Chen, S., Liu, Y., Zhou, Y., Chen, J."Profile and clinical significance of SPARCL1 and its prognostic significance in breast cancer". Oncology Letters 29, no. 4 (2025): 196. https://doi.org/10.3892/ol.2025.14942
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