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Review Special Issue Open Access

Novel clinical potential of poly (ADP‑ribose) polymerase inhibitors in triple‑negative breast cancer: Mechanistic insights and clinical applications (Review)

This article is part of the special Issue: Molecular target and action mechanism of anti-cancer agents
  • Authors:
    • Yu Han
    • Lei Wei
  • View Affiliations / Copyright

    Affiliations: School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430000, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 215
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    Published online on: March 4, 2025
       https://doi.org/10.3892/ol.2025.14961
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Abstract

Breast cancer is one of the most prevalent malignant tumors worldwide, and triple‑negative breast cancer (TNBC) presents a major therapeutic challenge due to the lack of effective targeted treatment options. Poly (ADP‑ribose) polymerase (PARP) plays a critical role in DNA damage repair, and its inhibitors have shown significant therapeutic efficacy in patients with TNBC exhibiting breast cancer susceptibility gene (BRCA) mutations. The present review aimed to analyze the molecular mechanisms of cell death induced by DNA damage related to PAR and PARP, thoroughly exploring the role of PARP in regulatory pathways. Additionally, it intended to highlight clinical trials and therapeutic outcomes of PARP inhibitors currently used in TNBC treatment. In particular, the current review delves into the mechanisms of drug resistance, such as BRCA mutation reversion and PARP protein trapping, and examines potential strategies to overcome PARP inhibitor resistance in the future. Ultimately, the present study aims to offer novel perspectives and research directions for further optimizing the application of PARP inhibitors in TNBC therapy.
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Spandidos Publications style
Han Y and Wei L: Novel clinical potential of poly (ADP‑ribose) polymerase inhibitors in triple‑negative breast cancer: Mechanistic insights and clinical applications (Review). Oncol Lett 29: 215, 2025.
APA
Han, Y., & Wei, L. (2025). Novel clinical potential of poly (ADP‑ribose) polymerase inhibitors in triple‑negative breast cancer: Mechanistic insights and clinical applications (Review). Oncology Letters, 29, 215. https://doi.org/10.3892/ol.2025.14961
MLA
Han, Y., Wei, L."Novel clinical potential of poly (ADP‑ribose) polymerase inhibitors in triple‑negative breast cancer: Mechanistic insights and clinical applications (Review)". Oncology Letters 29.5 (2025): 215.
Chicago
Han, Y., Wei, L."Novel clinical potential of poly (ADP‑ribose) polymerase inhibitors in triple‑negative breast cancer: Mechanistic insights and clinical applications (Review)". Oncology Letters 29, no. 5 (2025): 215. https://doi.org/10.3892/ol.2025.14961
Copy and paste a formatted citation
x
Spandidos Publications style
Han Y and Wei L: Novel clinical potential of poly (ADP‑ribose) polymerase inhibitors in triple‑negative breast cancer: Mechanistic insights and clinical applications (Review). Oncol Lett 29: 215, 2025.
APA
Han, Y., & Wei, L. (2025). Novel clinical potential of poly (ADP‑ribose) polymerase inhibitors in triple‑negative breast cancer: Mechanistic insights and clinical applications (Review). Oncology Letters, 29, 215. https://doi.org/10.3892/ol.2025.14961
MLA
Han, Y., Wei, L."Novel clinical potential of poly (ADP‑ribose) polymerase inhibitors in triple‑negative breast cancer: Mechanistic insights and clinical applications (Review)". Oncology Letters 29.5 (2025): 215.
Chicago
Han, Y., Wei, L."Novel clinical potential of poly (ADP‑ribose) polymerase inhibitors in triple‑negative breast cancer: Mechanistic insights and clinical applications (Review)". Oncology Letters 29, no. 5 (2025): 215. https://doi.org/10.3892/ol.2025.14961
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