Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2025 Volume 29 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2025 Volume 29 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Adrenal cortical carcinoma with non‑islet cell tumor hypoglycemia: A case report

  • Authors:
    • Yunpeng Li
    • Rui Yang
    • Liang Zhang
    • Jian Wang
    • Faying Yang
    • Song Tu
    • Jun Qian
    • Jiaxi Yao
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Hexi University Affiliated Zhangye People's Hospital, Zhangye, Gansu 734000, P.R. China, Xiangya Medical College, Central South University, Changsha, Hunan 410013, P.R. China, Department of Surgery, Shandan County Traditional Chinese Medicine Hospital, Zhangye, Gansu 734000, P.R. China, Department of Pathology, Hexi University Affiliated Zhangye People's Hospital, Zhangye, Gansu 734000, P.R. China, Department of Urology, Hexi University Affiliated Zhangye People's Hospital, Zhangye, Gansu 734000, P.R. China, Institute of Urology, Hexi University, Zhangye, Gansu 734000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 225
    |
    Published online on: March 7, 2025
       https://doi.org/10.3892/ol.2025.14971
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Adrenal cortical carcinoma (ACC) is a rare invasive cancer with a poor prognosis. ACC often manifests with hyperglycemia and Cushing syndrome. Hypoglycemia is an unusual manifestation of this malignant tumor; therefore, the diagnosis and management of patients with ACC and hypoglycemia is extremely challenging. The current study presents the case of a 53‑year‑old woman who experienced recurrent, uncontrolled hypoglycemia and episodes of hypoglycemic coma. The patient was diagnosed with right‑sided ACC and successfully treated with surgery. Hypoglycemic episodes associated with ACC are extremely rare. Moreover, the clinical diagnosis is often challenging owing to its similarity to multiple other diseases. Recurrent severe hypoglycemic comas, if not addressed promptly, can lead to patient death. Therefore, it is necessary to monitor patients with such rare diseases in clinical practice and make an accurate diagnosis promptly to ensure timely and effective treatment. This report of an ACC case with non‑islet cell tumor hypoglycemia aims to raise awareness among clinical physicians.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Torti JF and Correa R: Adrenal Cancer [M]. StatPearls; Treasure Island: 2025

2 

Wang Z, Deng JH, Wang X, Liu Y, Chen JY and Zhang YS: Changes in WHO classification of adrenal tumors and new ideas for multi-dimensional diagnosis and treatment. Zhonghua Wai Ke Za Zhi. 62:1001–1007. 2024.(In Chinese). PubMed/NCBI

3 

Yip L, Duh QY, Wachtel H, Jimenez C, Sturgeon C, Lee C, Velázquez-Fernández D, Berber E, Hammer GD, Bancos I, et al: American association of endocrine surgeons guidelines for adrenalectomy: Executive summary. JAMA Surg. 157:870–877. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC and Else T: American association of clinical endocrinology disease state clinical review on the evaluation and management of adrenocortical carcinoma in an adult: A practical approach. Endocr Pract. 26:1366–1383. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Iglesias P and Díez JJ: Management of endocrine disease: A clinical update on tumor-induced hypoglycemia. Eur J Endocrinol. 170:R147–R157. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Siddiqui M, Vora A, Ali S, Abramowitz J and Mirfakhraee S: Pasireotide: A novel treatment for tumor-induced hypoglycemia due to insulinoma and non-islet cell tumor hypoglycemia. J Endocr Soc. 5:bvaa1712020. View Article : Google Scholar : PubMed/NCBI

7 

Axelrod L and Ron D: Insulin-like growth factor II and the riddle of tumor-induced hypoglycemia. N Engl J Med. 319:1477–1479. 1988. View Article : Google Scholar : PubMed/NCBI

8 

Kim SW, Lee SE, Oh YL, Kim S, Park SH and Kim JH: Nonislet cell tumor hypoglycemia in a patient with adrenal cortical carcinoma. Case Rep Endocrinol. 2016:57314172016.PubMed/NCBI

9 

Marchetti KR, Pereira MA, Lichtenstein A and Paiva EF: Refractory hypoglycemia in a patient with functional adrenal cortical carcinoma. Endocrinol Diabetes Metab Case Rep. 201:16–0101. 2016.PubMed/NCBI

10 

Fukuda I, Hizuka N, Takano K, Asakawa-Yasumoto K, Shizume K and Demura H: Characterization of insulin-like growth factor II (IGF-II) and IGF binding proteins in patients with non-islet-cell tumor hypoglycemia. Endocr J. 40:111–119. 1993. View Article : Google Scholar : PubMed/NCBI

11 

Ishikura K, Takamura T, Takeshita Y, Nakagawa A, Imaizumi N, Misu H, Taji K, Kasahara K, Oshinoya Y, Suzuki S, et al: Cushing's syndrome and big IGF-II associated hypoglycaemia in a patient with adrenocortical carcinoma. BMJ Case Rep. 2010.bcr07.2009.2100. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Sinclair TJ, Gillis A, Alobuia WM, Wild H and Kebebew E: Surgery for adrenocortical carcinoma: When and how? Best Pract Res Clin Endocrinol Metab. 34:1014082020. View Article : Google Scholar : PubMed/NCBI

13 

Kamai T, Murakami S, Arai K, Ishida K and Kijima T: Association of Nrf2 expression and mutation with Weiss and Helsinki scores in adrenocortical carcinoma. Cancer Sci. 13:2368–2377. 2022. View Article : Google Scholar : PubMed/NCBI

14 

Gaujoux S, Weinandt M, Bonnet S, Reslinger V, Bertherat J and Dousset B: Surgical treatment of adrenal carcinoma. J Visc Surg. 154:335–343. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Puglisi S, Calabrese A, Basile V, Pia A, Reimondo G, Perotti P and Terzolo M: New perspectives for mitotane treatment of adrenocortical carcinoma. Best Pract Res Clin Endocrinol Metab. 34:1014152020. View Article : Google Scholar : PubMed/NCBI

16 

Karimi F, Dehghanian A, Fallahi M and Dalfardi B: Pure androgen-secreting adrenocortical carcinoma presenting with hypoglycemia. Arch Iran Med. 22:527–530. 2019.PubMed/NCBI

17 

Khadka S, Mandal S, Kasireddy V, Ghimire S, Maganti T and Mols-Kowalczewski B: Hypoglycemia in a patient with hypercortisolism and adrenocortical carcinoma: A paradoxical entity. J Adolesc Young Adult Oncol. 11:122–125. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Douillard C, Jannin A and Vantyghem MC: Rare causes of hypoglycemia in adults. Ann Endocrinol (Paris). 81:110–117. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Scalia P, Marino IR, Asero S, Pandini G, Grimberg A, El-Deiry WS and Williams SJ: Autocrine IGF-II-associated cancers: From a rare paraneoplastic event to a hallmark in malignancy. Biomedicines. 12:402023. View Article : Google Scholar : PubMed/NCBI

20 

Miller BS, Rogol AD and Rosenfeld RG: The history of the insulin-like growth factor system. Horm Res Paediatr. 95:619–630. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Holly JMP, Biernacka K and Perks CM: The neglected insulin: IGF-II, a metabolic regulator with implications for diabetes, obesity, and cancer. Cells. 8:12072019. View Article : Google Scholar : PubMed/NCBI

22 

Phan AT: Adrenal cortical carcinoma-review of current knowledge and treatment practices. Hematol Oncol Clin North Am. 21:489–507. viii–ix. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Angelousi A, Kassi E and Kaltsas GA: Adrenocortical Carcinoma. Endotext [Internet], MDText.com, Inc., South Dartmouth, MDText.com, Inc. 2025.

24 

Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G and Terzolo M: European society of endocrinology clinical practice guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European network for the study of adrenal tumors. Eur J Endocrinol. 179:G1–G46. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Fassnacht M, Terzolo M, Allolio B, Baudin E, Haak H, Berruti A, Welin S, Schade-Brittinger C, Lacroix A, Jarzab B, et al: Combination chemotherapy in advanced adrenocortical carcinoma. N Engl J Med. 366:2189–2197. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Deng JH, Li HZ, Ji ZG, Zhang Y and Liu GH: Comprehensive treatment of adrenal cortical carcinoma. Beijing Da Xue Xue Bao Yi Xue Ban. 51:298–301. 2019.(In Chinese). PubMed/NCBI

27 

Yeap BT, Teah KM, Tan JBG and Azizan N: Case report: A giant hemorrhagic adrenocortical carcinoma causing cardiorespiratory embarrassment. Ann Med Surg (Lond). 71:1029962021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Y, Yang R, Zhang L, Wang J, Yang F, Tu S, Qian J and Yao J: Adrenal cortical carcinoma with non‑islet cell tumor hypoglycemia: A case report. Oncol Lett 29: 225, 2025.
APA
Li, Y., Yang, R., Zhang, L., Wang, J., Yang, F., Tu, S. ... Yao, J. (2025). Adrenal cortical carcinoma with non‑islet cell tumor hypoglycemia: A case report. Oncology Letters, 29, 225. https://doi.org/10.3892/ol.2025.14971
MLA
Li, Y., Yang, R., Zhang, L., Wang, J., Yang, F., Tu, S., Qian, J., Yao, J."Adrenal cortical carcinoma with non‑islet cell tumor hypoglycemia: A case report". Oncology Letters 29.5 (2025): 225.
Chicago
Li, Y., Yang, R., Zhang, L., Wang, J., Yang, F., Tu, S., Qian, J., Yao, J."Adrenal cortical carcinoma with non‑islet cell tumor hypoglycemia: A case report". Oncology Letters 29, no. 5 (2025): 225. https://doi.org/10.3892/ol.2025.14971
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Yang R, Zhang L, Wang J, Yang F, Tu S, Qian J and Yao J: Adrenal cortical carcinoma with non‑islet cell tumor hypoglycemia: A case report. Oncol Lett 29: 225, 2025.
APA
Li, Y., Yang, R., Zhang, L., Wang, J., Yang, F., Tu, S. ... Yao, J. (2025). Adrenal cortical carcinoma with non‑islet cell tumor hypoglycemia: A case report. Oncology Letters, 29, 225. https://doi.org/10.3892/ol.2025.14971
MLA
Li, Y., Yang, R., Zhang, L., Wang, J., Yang, F., Tu, S., Qian, J., Yao, J."Adrenal cortical carcinoma with non‑islet cell tumor hypoglycemia: A case report". Oncology Letters 29.5 (2025): 225.
Chicago
Li, Y., Yang, R., Zhang, L., Wang, J., Yang, F., Tu, S., Qian, J., Yao, J."Adrenal cortical carcinoma with non‑islet cell tumor hypoglycemia: A case report". Oncology Letters 29, no. 5 (2025): 225. https://doi.org/10.3892/ol.2025.14971
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team