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Long‑term progression‑free survival in HR+/HER2+ advanced breast cancer with combination therapy with a CDK4/6 inhibitor and first‑line maintenance therapy: A case report

  • Authors:
    • Yihong Cai
    • Jinling Zhang
    • Hongxia Duan
    • Fan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Chemotherapy, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, P.R. China, Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, P.R. China
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 227
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    Published online on: March 10, 2025
       https://doi.org/10.3892/ol.2025.14973
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Abstract

The current standard treatment for hormone receptor (HR)‑positive and human epidermal growth factor receptor 2 (HER2)‑positive advanced breast cancer (BC) involves the use of anti‑HER2 monoclonal antibodies combined with chemotherapy, followed by sequential endocrine therapy. However, crosstalk between the HR and HER2 pathways may cause drug resistance. Combining therapies targeting both the HR and HER2 pathways may be a rational approach for patients with HR+/HER2+ tumors, as this strategy could counteract resistance by blocking crosstalk in the receptor pathway. However, clinical data in this field remain limited. The present report describes the case of a patient with HR+/HER2+ late‑stage BC who achieved a long‑term partial response rate after receiving anti‑HER2 combination chemotherapy followed by sequential treatment with endocrine therapy and cyclin‑dependent kinase 4/6 (CDK4/6) inhibitors. The present case provides additional evidence suggesting that incorporating CDK4/6 inhibitors into standard targeted chemotherapy regimens may be an effective treatment option for patients with HR+/HER2+ BC.
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Copy and paste a formatted citation
Spandidos Publications style
Cai Y, Zhang J, Duan H and Liu F: Long‑term progression‑free survival in HR+/HER2+ advanced breast cancer with combination therapy with a CDK4/6 inhibitor and first‑line maintenance therapy: A case report. Oncol Lett 29: 227, 2025.
APA
Cai, Y., Zhang, J., Duan, H., & Liu, F. (2025). Long‑term progression‑free survival in HR+/HER2+ advanced breast cancer with combination therapy with a CDK4/6 inhibitor and first‑line maintenance therapy: A case report. Oncology Letters, 29, 227. https://doi.org/10.3892/ol.2025.14973
MLA
Cai, Y., Zhang, J., Duan, H., Liu, F."Long‑term progression‑free survival in HR+/HER2+ advanced breast cancer with combination therapy with a CDK4/6 inhibitor and first‑line maintenance therapy: A case report". Oncology Letters 29.5 (2025): 227.
Chicago
Cai, Y., Zhang, J., Duan, H., Liu, F."Long‑term progression‑free survival in HR+/HER2+ advanced breast cancer with combination therapy with a CDK4/6 inhibitor and first‑line maintenance therapy: A case report". Oncology Letters 29, no. 5 (2025): 227. https://doi.org/10.3892/ol.2025.14973
Copy and paste a formatted citation
x
Spandidos Publications style
Cai Y, Zhang J, Duan H and Liu F: Long‑term progression‑free survival in HR+/HER2+ advanced breast cancer with combination therapy with a CDK4/6 inhibitor and first‑line maintenance therapy: A case report. Oncol Lett 29: 227, 2025.
APA
Cai, Y., Zhang, J., Duan, H., & Liu, F. (2025). Long‑term progression‑free survival in HR+/HER2+ advanced breast cancer with combination therapy with a CDK4/6 inhibitor and first‑line maintenance therapy: A case report. Oncology Letters, 29, 227. https://doi.org/10.3892/ol.2025.14973
MLA
Cai, Y., Zhang, J., Duan, H., Liu, F."Long‑term progression‑free survival in HR+/HER2+ advanced breast cancer with combination therapy with a CDK4/6 inhibitor and first‑line maintenance therapy: A case report". Oncology Letters 29.5 (2025): 227.
Chicago
Cai, Y., Zhang, J., Duan, H., Liu, F."Long‑term progression‑free survival in HR+/HER2+ advanced breast cancer with combination therapy with a CDK4/6 inhibitor and first‑line maintenance therapy: A case report". Oncology Letters 29, no. 5 (2025): 227. https://doi.org/10.3892/ol.2025.14973
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