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Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis

  • Authors:
    • Tsung-Chiao Tsai
    • Junmin Song
    • Kuan-Yu Chi
    • Hong-Min Lin
    • Yu Chang
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C., Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York City, NY 10461, USA, Department of Family Medicine, Chi‑Mei Medical Center, Tainan 710, Taiwan, R.O.C.
    Copyright: © Tsai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 233
    |
    Published online on: March 17, 2025
       https://doi.org/10.3892/ol.2025.14979
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Abstract

Synchronous and metachronous brain metastases (BM) are increasingly recognized in patients with colorectal cancer (CRC). This study aimed to assess whether the timing of BM development affects survival outcomes by conducting a systematic review and meta‑analysis. A comprehensive search of the Cochrane Library, Embase and MEDLINE databases was performed, covering studies from January 1900 to December 2023. To compare survival outcomes between synchronous and metachronous BM, hazard ratios (HRs) for overall survival (OS) were extracted from the included studies and pooled using a random‑effects model. The systematic review included nine retrospective cohort studies comprising 910 patients with BM from CRC. Meta‑analysis results showed no significant difference in OS between patients with synchronous and metachronous BM (HR, 0.90; 95% confidence interval, 0.59‑1.38; P=0.63). In conclusion, this meta‑analysis suggests that the timing of BM development does not impact OS in patients with BM from CRC.
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1 

Zeineddine FA, Zeineddine MA, Yousef A, Gu Y, Chowdhury S, Dasari A, Huey RW, Johnson B, Kee B, Lee MS, et al: Survival improvement for patients with metastatic colorectal cancer over twenty years. NPJ Precis Oncol. 7:162023. View Article : Google Scholar : PubMed/NCBI

2 

Müller S, Köhler F, Hendricks A, Kastner C, Börner K, Diers J, Lock JF, Petritsch B, Germer CT and Wiegering A: Brain metastases from colorectal cancer: A systematic review of the literature and meta-analysis to establish a guideline for daily treatment. Cancers (Basel). 13:9002021. View Article : Google Scholar : PubMed/NCBI

3 

Nieder C, Spanne O, Mehta MP, Grosu AL and Geinitz H: Presentation, patterns of care, and survival in patients with brain metastases: What has changed in the last 20 years? Cancer. 117:2505–2512. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Ruste V, Sunyach MP, Tanguy R, Jouanneau E, Schiffler C, Carbonnaux M, Moriceau G, Neidhardt EM, Boyle H, Robin S, et al: Synchronous brain metastases as a poor prognosis factor in clear cell renal carcinoma: A strong argument for systematic brain screening. J Neurooncol. 153:133–141. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Potthoff AL, Heimann M, Lehmann F, Ilic I, Paech D, Borger V, Radbruch A, Schäfer N, Schuss P, Vatter H, et al: Survival after resection of brain metastasis: Impact of synchronous versus metachronous metastatic disease. J Neurooncol. 161:539–545. 2023. View Article : Google Scholar : PubMed/NCBI

6 

Reddy SP, Dowell JE and Pan E: Predictors of prognosis of synchronous brain metastases in small-cell lung cancer patients. Clin Exp Metastasis. 37:531–539. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Bergen ES, Scherleitner P, Ferreira P, Kiesel B, Müller C, Widhalm G, Dieckmann K, Prager G, Preusser M and Berghoff AS: Primary tumor side is associated with prognosis of colorectal cancer patients with brain metastases. ESMO Open. 6:1001682021. View Article : Google Scholar : PubMed/NCBI

8 

Chang Y, Wong CE, Lee PH, Huang CC and Lee JS: Survival outcome of surgical resection vs. radiotherapy in brain metastasis from colorectal cancer: A meta-analysis. Front Med (Lausanne). 9:7688962022. View Article : Google Scholar : PubMed/NCBI

9 

Imaizumi J, Shida D, Narita Y, Miyakita Y, Tanabe T, Takashima A, Boku N, Igaki H, Itami J and Kanemitsu Y: Prognostic factors of brain metastases from colorectal cancer. BMC Cancer. 19:7552019. View Article : Google Scholar : PubMed/NCBI

10 

Lan YT, Chang SC, Lin PC, Lin CC, Lin HH, Huang SC, Lin CH, Liang WY, Chen WS, Jiang JK, et al: Clinicopathological and molecular features between synchronous and metachronous metastases in colorectal cancer. Am J Cancer Res. 11:1646–1658. 2021.PubMed/NCBI

11 

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ and Welch VA: Cochrane handbook for systematic reviews of interventions version 6.5 (updated August 2024). Cochrane. 2024.Available from:. www.training.cochrane.org/handbook

12 

Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, Henry D, Altman DG, Ansari MT, Boutron I, et al: ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 355:i49192016. View Article : Google Scholar : PubMed/NCBI

13 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Higgins JPT and Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 21:1539–1558. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Baek JY, Kang MH, Hong YS, Kim TW, Kim DY, Oh JH, Lee SH, Park JH, Kim JH and Kim SY: Characteristics and prognosis of patients with colorectal cancer-associated brain metastases in the era of modern systemic chemotherapy. J Neurooncol. 104:745–753. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Chen CW, Ou TS, Chen WS, Jiang JK, Yang SH, Wang HS, Chang SC, Lan YT, Lin CC, Lin HH, et al: Anti-VEGF therapy possibly extends survival in patients with colorectal brain metastasis by protecting patients from neurologic disability. Clin Colorectal Cancer. 22:267–279. 2023. View Article : Google Scholar : PubMed/NCBI

17 

Lu X, Cai Y, Xia L, Ju H and Zhao X: Treatment modalities and relative survival in patients with brain metastasis from colorectal cancer. Biosci Trends. 13:182–188. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Magni E, Santoro L, Ravenda PS, Leonardi MC, Bonomo G, Monfardini L, Nolè F and Zampino MG: Brain metastases from colorectal cancer: Main clinical factors conditioning outcome. Int J Colorectal Dis. 29:201–208. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Mege D, Ouaissi M, Fuks D, Metellus P, Peltier J, Dufour H, Regimbeau JM, Dahan L, Sielezneff I and Sastre B: Patients with brain metastases from colorectal cancer are not condemned. Anticancer Res. 33:5645–5648. 2013.PubMed/NCBI

20 

Roussille P, Auvray M, Vansteene D, Lecomte T, Rigault E, Maillet M, Locher C, Dior M, Hautefeuille V, Artru P, et al: Prognostic factors of colorectal cancer patients with brain metastases. Radiother Oncol. 158:67–73. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Schoeggl A, Kitz K, Reddy M and Zauner C: Stereotactic radiosurgery for brain metastases from colorectal cancer. Int J Colorectal Dis. 17:150–155. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Tanriverdi O, Kaytan-Saglam E, Ulger S, Bayoglu IV, Turker I, Ozturk-Topcu T, Cokmert S, Turhal S, Oktay E, Karabulut B, et al: The clinical and pathological features of 133 colorectal cancer patients with brain metastasis: a multicenter retrospective analysis of the Gastrointestinal Tumors Working Committee of the Turkish Oncology Group (TOG). Med Oncol. 31:1522014. View Article : Google Scholar : PubMed/NCBI

23 

Wang D, Chen C, Ge X, Yang Q, Huang Y, Ling T, Jin T, Yu S, Wang J and Sun L: Factors prognostic for brain metastases from colorectal cancer: A single-center experience in China. Cancer Manag Res. 13:6767–6774. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Flannery TW, Suntharalingam M, Kwok Y, Koffman BH, Amin PP, Chin LS, Nicol B, Fowler Z, Young AB and Regine WF: Gamma knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancer. Lung Cancer. 42:327–333. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Kye BH, Kim HJ, Kang WK, Cho HM, Hong YK and Oh ST: Brain metastases from colorectal cancer: The role of surgical resection in selected patients. Colorectal Dis. 14:e378–e385. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Navarria P, Minniti G, Clerici E, Comito T, Cozzi S, Pinzi V, Fariselli L, Ciammella P, Scoccianti S, Borzillo V, et al: Brain metastases from primary colorectal cancer: Is radiosurgery an effective treatment approach? Results of a multicenter study of the radiation and clinical oncology Italian association (AIRO). Br J Radiol. 93:202009512020. View Article : Google Scholar : PubMed/NCBI

27 

Koo T, Kim K, Park HJ, Han SW, Kim TY, Jeong SY, Park KJ and Chie EK: Prognostic factors for survival in colorectal cancer patients with brain metastases undergoing whole brain radiotherapy: Multicenter retrospective study. Sci Rep. 10:43402020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tsai T, Song J, Chi K, Lin H and Chang Y: Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis. Oncol Lett 29: 233, 2025.
APA
Tsai, T., Song, J., Chi, K., Lin, H., & Chang, Y. (2025). Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis. Oncology Letters, 29, 233. https://doi.org/10.3892/ol.2025.14979
MLA
Tsai, T., Song, J., Chi, K., Lin, H., Chang, Y."Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis". Oncology Letters 29.5 (2025): 233.
Chicago
Tsai, T., Song, J., Chi, K., Lin, H., Chang, Y."Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis". Oncology Letters 29, no. 5 (2025): 233. https://doi.org/10.3892/ol.2025.14979
Copy and paste a formatted citation
x
Spandidos Publications style
Tsai T, Song J, Chi K, Lin H and Chang Y: Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis. Oncol Lett 29: 233, 2025.
APA
Tsai, T., Song, J., Chi, K., Lin, H., & Chang, Y. (2025). Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis. Oncology Letters, 29, 233. https://doi.org/10.3892/ol.2025.14979
MLA
Tsai, T., Song, J., Chi, K., Lin, H., Chang, Y."Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis". Oncology Letters 29.5 (2025): 233.
Chicago
Tsai, T., Song, J., Chi, K., Lin, H., Chang, Y."Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis". Oncology Letters 29, no. 5 (2025): 233. https://doi.org/10.3892/ol.2025.14979
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