Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2025 Volume 29 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2025 Volume 29 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Treatment outcomes and safety of reduced‑dose venetoclax plus antifungal agents to treat acute myeloid leukemia: A single hospital experience in Taiwan

  • Authors:
    • Sheng-Yen Hsiao
    • Kun-Yu Wu
    • Wen-Tsung Huang
    • Cheng-Yao Lin
    • Kuan-Yu Chen
    • Teng-Song Weng
  • View Affiliations / Copyright

    Affiliations: Division of Hematology‑Oncology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan 736402, Taiwan, R.O.C., Department of Radiology, Chi Mei Medical Center, Liouying, Tainan 736402, Taiwan, R.O.C., Department of Pharmacy, Chi Mei Medical Center, Liouying, Tainan 736402, Taiwan, R.O.C.
    Copyright: © Hsiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 241
    |
    Published online on: March 21, 2025
       https://doi.org/10.3892/ol.2025.14987
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Venetoclax, an orally administered B‑cell lymphoma 2 inhibitor, requires dose adjustments when coadministered with cytochrome P450 inhibitors in patients with acute myeloid leukemia (AML). The present study retrospectively analyzed data on progression‑free survival (PFS), overall survival (OS) and drug‑related adverse events in patients with AML who received adjusted low‑dose venetoclax with antifungal agents, compared with those receiving conventional chemotherapy regimens (I3A7, LDAC, and I2A5) , at a single hospital. In total, 45 patients with AML who were treated between January 2015 and December 2021 were retrospectively included. A significantly longer median OS time was observed in the group receiving idarubicin [12 mg/m² intravenous (IV) on days 1‑3] and cytarabine (100 mg/m² continuous IV infusion on days 1‑7) (I3A7 group) (median not reached) compared with that in the venetoclax group [10.7 months; 95% confidence interval (CI), 6.3‑20.8], the low‑dose cytarabine (LDAC) group (4.7 months; 95% CI, 0.8‑18.7) and the group receiving idarubicin (12 mg/m² IV on days 1‑2) with cytarabine (100 mg/m² continuous IV infusion on days 1‑5) (I2A5 group) (2.3 months; 95% CI, 0.5‑2.3). Similarly, the median PFS time was significantly longer in the I3A7 group (29.0 months; 95% CI, 1.1‑29.0) compared with that in the venetoclax (8.0 months; 95% CI, 0.8‑10.8), LDAC (2.1 months; 95% CI, 0.1‑6.4) and I2A5 (0.9 months; 95% CI, 0.1‑4.7) groups. Grade 3 or higher adverse hematological events were common across all treatment groups. Cardiovascular events and grade 3 or higher tumor lysis syndrome occurred only in the venetoclax group (14 and 7%, respectively). In conclusion, low‑dose venetoclax combined with antifungal agents appears to be less effective than standard treatment but superior to both LDAC and the I2A5 treatment regimens. Venetoclax also demonstrates a relatively low infection risk. However, careful monitoring for cardiovascular events and tumor lysis syndrome during venetoclax administration is crucial, particularly in patients with relevant medical histories.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Lessene G, Czabotar PE and Colman PM: Bcl-2 family antagonists for cancer therapy. Nat Rev Drug Discov. 7:989–1000. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Letai AG: Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat Rev Cancer. 8:121–132. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Marzo I and Naval J: Bcl-2 family members as molecular targets in cancer therapy. Biochem Pharmacol. 76:939–946. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Scarfò L and Ghia P: Reprogramming cell death: Bcl2 family inhibition in hematological malignancies. Immunol Lett. 155:36–39. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Anderson MA, Deng J, Seymour JF, Tam CK, Kim SY, Fein J, Yu L, Brown JR, Westerman D, Si EG, et al: The bcl2 selective inhibitor venetoclax induces rapid onset apoptosis of cll cells in patients via a tp53-independent mechanism. Blood. 127:3215–3224. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Robak T, Smolewski P, Robak P and Dreyling M: Mantle cell lymphoma: Therapeutic options in transplant-ineligible patients. Leuk Lymphoma. 60:2622–2634. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Bhatt P, Kloock C and Comenzo R: Relapsed/refractory multiple myeloma: A review of available therapies and clinical scenarios encountered in myeloma relapse. Curr Oncol. 30:2322–2347. 2023. View Article : Google Scholar : PubMed/NCBI

8 

El-Cheikh J, Bidaoui G, Saleh M, Moukalled N, Dalle IA and Bazarbachi A: Venetoclax: A new partner in the novel treatment era for acute myeloid leukemia and myelodysplastic syndrome. Clin Hematol Int. 5:143–154. 2023. View Article : Google Scholar : PubMed/NCBI

9 

Laurenti L, Scarfò L, Frustaci AM, Sanna A, Iannella E, Caira M, Finsinger P, Schifano S, Neri B, Molica S and Mauro FR: Real-world evidence on venetoclax in chronic lymphocytic leukemia: The Italian experience. Hematol Oncol. 41:621–630. 2023. View Article : Google Scholar : PubMed/NCBI

10 

Cramer P, von Tresckow J, Bahlo J, Robrecht S, Langerbeins P, Al-Sawaf O, Engelke A, Fink AM, Fischer K, Tausch E, et al: Bendamustine followed by obinutuzumab and venetoclax in chronic lymphocytic leukaemia (cll2-bag): Primary endpoint analysis of a multicentre, open-label, phase 2 trial. Lancet Oncol. 19:1215–1228. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Seymour JF, Kipps TJ, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Gerecitano J, Robak T, De la Serna J, et al: Venetoclax-rituximab in relapsed or refractory chronic lymphocytic leukemia. N Engl J Med. 378:1107–1120. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Al-Sawaf O, Zhang C, Tandon M, Sinha A, Fink AM, Robrecht S, Samoylova O, Liberati AM, Pinilla-Ibarz J, Opat S, et al: Venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab for previously untreated chronic lymphocytic leukaemia (cll14): Follow-up results from a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 21:1188–1200. 2020. View Article : Google Scholar : PubMed/NCBI

13 

DiNardo CD, Jonas BA, Pullarkat V, Thirman MJ, Garcia JS, Wei AH, Konopleva M, Döhner H, Letai A, Fenaux P, et al: Azacitidine and venetoclax in previously untreated acute myeloid leukemia. N Engl J Med. 383:617–629. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Kumar SK, Harrison SJ, Cavo M, de la Rubia J, Popat R, Gasparetto C, Hungria V, Salwender H, Suzuki K, Kim I, et al: Venetoclax or placebo in combination with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma (bellini): A randomised, double-blind, multicentre, phase 3 trial. Lancet Oncol. 21:1630–1642. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Wei AH, Montesinos P, Ivanov V, DiNardo CD, Novak J, Laribi K, Kim I, Stevens DA, Fiedler W, Pagoni M, et al: Venetoclax plus ldac for newly diagnosed aml ineligible for intensive chemotherapy: A phase 3 randomized place-bo-controlled trial. Blood. 135:2137–2145. 2020. View Article : Google Scholar : PubMed/NCBI

16 

DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, et al: Venetoclax combined with flag-ida induction and consolidation in newly diagnosed and relapsed or refractory acute myeloid leukemia. J Clin Oncol. 39:2768–2778. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Wei AH, Panayiotidis P, Montesinos P, Laribi K, Ivanov V, Kim I, Novak J, Stevens DA, Fiedler W, Pagoni M, et al: 6-month follow-up of viale-c demonstrates improved and durable efficacy in patients with untreated aml ineligible for intensive chemotherapy (141/150). Blood Cancer J. 11:1632021. View Article : Google Scholar : PubMed/NCBI

18 

Wierda WG, Allan JN, Siddiqi T, Kipps TJ, Opat S, Tedeschi A, Badoux XC, Kuss BJ, Jackson S, Moreno C, et al: Ibrutinib plus venetoclax for first-line treatment of chronic lymphocytic leukemia: Primary analysis results from the minimal residual disease cohort of the randomized phase ii captivate study. J Clin Oncol. 39:3853–3865. 2021. View Article : Google Scholar : PubMed/NCBI

19 

Yamamoto K, Shinagawa A, DiNardo CD, Pratz KW, Ishizawa K, Miyamoto T, Komatsu N, Nakashima Y, Yoshida C, Fukuhara N, et al: Venetoclax plus azacitidine in Japanese patients with untreated acute myeloid leukemia ineligible for intensive chemotherapy. Jpn J Clin Oncol. 52:29–38. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Eichhorst B, Niemann CU, Kater AP, Fürstenau M, von Tresckow J, Zhang C, Robrecht S, Gregor M, Juliusson G, Thornton P, et al: First-line venetoclax combinations in chronic lymphocytic leukemia. N Engl J Med. 388:1739–1754. 2023. View Article : Google Scholar : PubMed/NCBI

21 

Azanza JR, Mensa J, Barberán J, Vázquez L, de Oteyza JP, Kwon M, Yáñez L, Aguado JM, Gracian AC, Solano C, et al: Recommendations on the use of azole antifungals in hematology-oncology patients. Rev Esp Quimioter. 3:236–258. 2023. View Article : Google Scholar : PubMed/NCBI

22 

U.S. Food and Drug Administration (FDA), . Drug development and drug interactions: Table of substrates, inhibitors and inducers. FDA, Silver Spring, MD. 2024.https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducers#table2-2November 7–2024

23 

Brüggemann RJ, Alffenaar JW, Blijlevens NM, Billaud EM, Kosterink JG, Verweij PE and Burger DM: Clinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents. Clin Infect Dis. 48:1441–1458. 2009. View Article : Google Scholar : PubMed/NCBI

24 

U.S. Food and Drug Administration (FDA), . Venetoclax prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208573s000lbl.pdfNovember 7–2024

25 

Agarwal SK, DiNardo CD, Potluri J, Dunbar M, Kantarjian HM, Humerickhouse RA, Wong SL, Menon RM, Konopleva MY and Salem AH: Management of venetoclax-posaconazole interaction in acute myeloid leukemia patients: Evaluation of dose adjustments. Clin Ther. 39:359–367. 2017. View Article : Google Scholar : PubMed/NCBI

26 

De la Garza-Salazar F, Colunga-Pedraza PR, Gómez-Almaguer D, García-Zárate VA and Gómez-De León A: Low dose venetoclax plus itraconazole outpatient induction in newly diagnosed acute myeloid leukemia: A phase 2 study. Leuk Res. 133:1073732023. View Article : Google Scholar : PubMed/NCBI

27 

Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR and Sultan C: Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol. 33:451–458. 1976. View Article : Google Scholar : PubMed/NCBI

28 

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET and Carbone PP: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

29 

Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ and Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group, : Refinement of cytogenetic classification in acute myeloid leukemia: Determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the UK MRC trials. Blood. 116:354–365. 2010. View Article : Google Scholar : PubMed/NCBI

30 

National Cancer Institute, . Terminology Criteria for Adverse Events (CTCAE). Version 5.0. https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_5×7.pdfNovember 7–2024

31 

Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, et al: Diagnosis and management of aml in adults: 2017 eln recommendations from an international expert panel. Blood. 129:424–447. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Estey E and Döhner H: Acute myeloid leukaemia. Lancet. 368:1894–1907. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Klepin HD, Geiger AM, Tooze JA, Kritchevsky SB, Williamson JD, Pardee TS, Ellis LR and Powell BL: Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia. Blood. 121:4287–4294. 2013. View Article : Google Scholar : PubMed/NCBI

34 

National comprehensive cancer network (NCCN), . Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Acute myeloid leukemia, Version (3.2024). NCCN, Plymouth Meeting, PA. 2024.https://www.nccn.org/professionals/physician_gls/pdf/aml.pdfNovember 7–2024

35 

Aldoss I, Dadwal S, Zhang J, Tegtmeier B, Mei M, Arslan S, Al Malki MM, Salhotra A, Ali H, Aribi A, et al: Invasive fungal infections in acute myeloid leukemia treated with venetoclax and hypomethylating agents. Blood Adv. 10:4043–4049. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Zhang A, Johnson T, Abbott D, Phupitakphol T, Gutman JA, Pollyea DA and Koullias Y: Incidence of invasive fungal infections in patients with previously untreated acute myeloid leukemia receiving venetoclax and azacitidine. Open Forum Infect Dis. 9:ofac4862022. View Article : Google Scholar : PubMed/NCBI

37 

AlAsmari AF, Alghamdi A, Ali N, Almeaikl MA, Hakami HM, Alyousef MK, AlSwayyed M, Alharbi M, Alqahtani F, Alasmari F and Alsaleh N: Venetoclax induces cardiotoxicity through modulation of oxidative-stress-mediated cardiac inflammation and apoptosis via NF-κB and BCL-2 pathway. Int J Mol Sci. 23:62602022. View Article : Google Scholar : PubMed/NCBI

38 

Freise KJ, Hu B and Salem AH: Impact of ritonavir dose and schedule on cyp3a inhibition and venetoclax clinical pharmacokinetics. Eur J Clin Pharmacol. 74:413–421. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Agarwal SK, Salem AH, Danilov AV, Hu B, Puvvada S, Gutierrez M, Chien D, Lewis LD and Wong SL: Effect of ketoconazole, a strong cyp3a inhibitor, on the pharmacokinetics of venetoclax, a BCL-2 inhibitor, in patients with non-hodgkin lymphoma. Br J Clin Pharmacol. 83:846–854. 2017. View Article : Google Scholar : PubMed/NCBI

40 

De la Garza-Salazar F, Peña-Lozano SP and Gómez-Almaguer D and Gómez-Almaguer D: Orbital myeloid sarcoma treated with low-dose venetoclax and a potent cytochrome p450 inhibitor. J Oncol Pharm Pract. 29:493–497. 2023. View Article : Google Scholar : PubMed/NCBI

41 

De la Garza-Salazar F, Colunga-Pedraza PR and Gómez-Almaguer D: Cytochrome p450 inhibition to decrease dosage and costs of venetoclax and ibrutinib: A proof-of-concept case study. Br J Clin Pharmacol. 89:898–902. 2023. View Article : Google Scholar : PubMed/NCBI

42 

Bhatnagar S, Mukherjee D and Salem AH: Dose adjustment of venetoclax when co-administered with posaconazole: Clinical drug-drug interaction predictions using a pbpk approach. Cancer Chemother Pharmacol. 87:465–474. 2021. View Article : Google Scholar : PubMed/NCBI

43 

Kobayashi M, Yasu T, Suzaki K and Kosugi N: Utility of therapeutic drug monitoring of venetoclax in acute myeloid leukemia. Oncology. 39:1–5. 2022.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hsiao S, Wu K, Huang W, Lin C, Chen K and Weng T: Treatment outcomes and safety of reduced‑dose venetoclax plus antifungal agents to treat acute myeloid leukemia: A single hospital experience in Taiwan. Oncol Lett 29: 241, 2025.
APA
Hsiao, S., Wu, K., Huang, W., Lin, C., Chen, K., & Weng, T. (2025). Treatment outcomes and safety of reduced‑dose venetoclax plus antifungal agents to treat acute myeloid leukemia: A single hospital experience in Taiwan. Oncology Letters, 29, 241. https://doi.org/10.3892/ol.2025.14987
MLA
Hsiao, S., Wu, K., Huang, W., Lin, C., Chen, K., Weng, T."Treatment outcomes and safety of reduced‑dose venetoclax plus antifungal agents to treat acute myeloid leukemia: A single hospital experience in Taiwan". Oncology Letters 29.5 (2025): 241.
Chicago
Hsiao, S., Wu, K., Huang, W., Lin, C., Chen, K., Weng, T."Treatment outcomes and safety of reduced‑dose venetoclax plus antifungal agents to treat acute myeloid leukemia: A single hospital experience in Taiwan". Oncology Letters 29, no. 5 (2025): 241. https://doi.org/10.3892/ol.2025.14987
Copy and paste a formatted citation
x
Spandidos Publications style
Hsiao S, Wu K, Huang W, Lin C, Chen K and Weng T: Treatment outcomes and safety of reduced‑dose venetoclax plus antifungal agents to treat acute myeloid leukemia: A single hospital experience in Taiwan. Oncol Lett 29: 241, 2025.
APA
Hsiao, S., Wu, K., Huang, W., Lin, C., Chen, K., & Weng, T. (2025). Treatment outcomes and safety of reduced‑dose venetoclax plus antifungal agents to treat acute myeloid leukemia: A single hospital experience in Taiwan. Oncology Letters, 29, 241. https://doi.org/10.3892/ol.2025.14987
MLA
Hsiao, S., Wu, K., Huang, W., Lin, C., Chen, K., Weng, T."Treatment outcomes and safety of reduced‑dose venetoclax plus antifungal agents to treat acute myeloid leukemia: A single hospital experience in Taiwan". Oncology Letters 29.5 (2025): 241.
Chicago
Hsiao, S., Wu, K., Huang, W., Lin, C., Chen, K., Weng, T."Treatment outcomes and safety of reduced‑dose venetoclax plus antifungal agents to treat acute myeloid leukemia: A single hospital experience in Taiwan". Oncology Letters 29, no. 5 (2025): 241. https://doi.org/10.3892/ol.2025.14987
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team